Ketodin cream

General characteristics. Structure:

International and chemical names: Ketokonazol; tsis-1-atsetil-4-[4-[[2-(2,4 dichlorophenyl)-2-(1H-imidazole-1-илметил) - 1,3-dioxolane-4-silt] metoks] phenyl] piperazin;
main physical and chemical properties: cream of white color, inodorous homogeneous consistence;
structure: 1 g of cream contains 20 mg of Ketokonazol; excipients: propylene glycol, stearyl alcohol, cetyl alcohol, sorbitan stearate, polysorbate 60, an isopropyl myristate, sodium sulfite anhydrous, polysorbate 80, the water purified.

Pharmacological properties:

Pharmacodynamics. Ketokonazol is to synthetic derivatives of an imidazoldioksolan. Possesses expressed fungicidal and a fungistasis on dermatophytes (Trichophyton spp., Epidermophyton floccosum, Microsporum spp.), barmy mushrooms (Candida spp., Pityrosporum spp., Torulopsis spp, Cryptococcus spp., Rhodotorula spp.), dimorphous and highest mushrooms (zumitset). Are less sensitive to Ketokonazol Aspergillus spp., Sporothrix schenckii, some Dermatiaceae, Mucor spp. and other fukomitseta, except for Entomophthrales. Ketokonazol is active also in relation to gram-positive cocci (Staphylococcus spp., Streptococcus spp.). The mechanism of its action consists in ergosterol biosynthesis inhibition that breaks lipidic structure of a membrane of mushrooms and causes their lysis. Ketodin quickly removes a peeling and an itch of skin. Development of secondary resistance during treatment by Ketokonazol till this time was not observed.

Pharmacokinetics. At topical administration Ketodin does not show systemic action, absorption of drug through skin insignificant or is absent.

Indications to use:

The treatment of infections of skin and nails caused by dermatophytes or drozhzhepodobny mushrooms, sensitive to drug (a skin dermatomycosis, an inguinal epidermophitia, an epidermophitia of brushes and feet, an onychomycosis (in a combination with system antifungal drug), paronychias, caused by kandida, a chromophytosis, seborrheal dermatitis, a folliculitis caused by Pityrosporum ovale, chronic candidiasis of skin; diaper dermatitis and intertrigo. Prevention of fungal infections of skin at persons, inclined to fungus diseases, or at high risk of their emergence: immunosuppressive therapy, prolonged treatment by system antibacterial agents, persons with professional or long household contact of skin with water: visit of baths, pools, etc.

Route of administration and doses:

Ketodin apply to adults and children on an affected area of skin, and also on sites which directly adjoin to it. The route of administration and average duration of treatment are specified in the table:

DISEASE	USE	COURSE OF TREATMENT
Dermatomycosis of smooth skin	1 time a day	3-4 weeks
Inguinal epidermophitia	1 time a day	2-4 weeks
Epidermophitia of brushes and feet	1 time a day	4-6 weeks
Chromophytosis	1 time a day	2-3 weeks
Skin candidiasis	1 time a day	2-3 weeks
Seboreyny dermatitis	2 times a day	2-4 weeks
Diaper dermatitis and intertrigo	1 time a day	1 week

 

Features of use:

If during treatment there is a burning, irritation, a skin itch, then it is recommended to apply a local glucocorticosteroid in parallel with Ketodin. In case of drug use at once after prolonged treatment by a local glucocorticosteroid emergence of irritation of skin for which elimination it is recommended to continue topical treatment by a glucocorticosteroid in the morning is possible, and in evening to apply Ketodin. Gradually for 2-3 weeks the dose of a corticosteroid is reduced to its full cancellation. If earlier the strong glucocorticosteroid was applied, it can be replaced with weaker. It is impossible to apply Ketodin to treatment of fungal infections of eyes.

Pregnancy and feeding by a breast. As system absorption of a ketokonazol at topical administration is absent, drug can be used during pregnancy and feeding by a breast.

Influence on ability to drive the car or to work with difficult mechanisms. Does not influence.

Use for persons up to 18 years. Drug can be used at children from the moment of the birth.

Side effects:

Emergence of burning, itch, irritation of skin is very seldom possible, especially in the first days of use which pass independently and do not demand treatment. At persons with individual hypersensitivity to a ketokonazol or other components of drug emergence of allergic reactions is possible.

Interaction with other medicines:

Interaction with other medicines is not revealed.

Contraindications:

Hypersensitivity to Ketokonazol or other components of drug.

Overdose:

There are no data on local overdose of drug. In case of accidental drawing a large amount of cream on skin it needs to be washed away water. At emergence of local reactions a symptomatic treatment.

Storage conditions:

To store at a temperature from +15 °C to +25 °C. To store in the place, unavailable to children. The deadline of storage is specified on packaging after the words "Use to.". The period of validity of drug makes 2 years.

Issue conditions:

Without recipe

Packaging:

On 15 g in tubas aluminum with membranes and covers.