Dibazol-Darnitsa

General characteristics. Structure:

Acting veshchestvo:bendazol;

1 tablet contains Bendazolum of a hydrochloride 20 mg;

excipients: lactose monohydrate, potato starch, talc, calcium stearate.

Pharmacological properties:

Bendazolum – vazodilatiruyushchy and an antispasmodic. It possesses hypotensive, vasodilating action, stimulates function of a spinal cord, renders the moderate immunostimulating effect.

Has direct spasmolytic effect on unstriated muscles of blood vessels and internals. Drug causes short (2-3 hours) and the moderate hypotensive effect, is well transferred. Causes short expansion of brain vessels at the chronic hypoxia of a brain caused by local disturbance of blood circulation (a sclerosis of cerebral arteries). Facilitates synoptic transfer in a spinal cord.

Dibazolum stimulates products of antibodies, increases phagocytal activity of leukocytes, macrophages, improves interferon synthesis, but the immunomodulatory effect of Dibazolum develops slowly.

It is quickly soaked up in digestive tract. The therapeutic effect occurs in 30-60 minutes after administration of drug. Duration of action makes        2-3 hours. Drug preferential with urine is removed.

Indications to use:

Arterial hypertension (as additional therapy). Diseases of a nervous system – the residual phenomena of poliomyelitis, a flaccid paralysis of a facial nerve, polyneurites, a syndrome of sluggish paralysis.

Route of administration and doses:

As the antispasmodic to adults and children is more senior than 12 years drug appoint inside 20-40 mg (1-2 tablets) 2-3 times a day. Accept Dibazol-Darnitsa in 2 hours prior to food or in 2 hours after food.

The highest doses for adults inside: one-time – 40 mg, daily – 120 mg.

Features of use:

Necessary security measures at use.

Before an initiation of treatment consult to the doctor!

Dibazolum in the form of tablets is supportive application which is used at arterial hypertension on condition of sensitivity to other antihypertensives. At treatment of arterial hypertension it is recommended to combine with other hypotensive drugs.

Prolonged use of Dibazola-Darnitsa as anti-hypertensive means the patient of old age because of a possibility of deterioration in indicators of an ECG, reduction of cordial emission is inexpedient.

It is not recommended to apply to prolonged treatment of arterial hypertension, especially to patients of advanced age.

Drug contains lactose therefore to patients with rare hereditary forms of intolerance of a galactose, insufficiency of lactase or a syndrome of glyukozo-galaktozny malabsorption it is impossible to use drug.

Use during pregnancy or feeding by a breast.

Not to use drug during pregnancy or feeding by a breast.

Ability to influence the speed of reactions at control of motor transport or work with other mechanisms.

During treatment it is necessary to be careful at control of vehicles and work with difficult mechanisms, and in case of developing of dizziness to refrain from work with potentially dangerous types of activity which demand the increased concentration of attention and speed of psychomotor reactions.

Children.

Drug is not appointed to children aged up to 12 years.

Side effects:

Nayboly frequent side effects:

from the central and peripheral nervous system: dizziness, headache;

from cardiovascular system: a heart consciousness, pain in heart, at prolonged use – deterioration in indicators of an ECG in connection with reduction of cordial emission, a lowering of arterial pressure;

from respiratory system: dry cough, cold, the complicated breath;

from the alimentary system: nausea, burning in a throat;

from immune system: itch, hyperemia, rashes, urticaria;

general disturbances: feeling of heat, the increased sweating, face reddening.

Interaction with other medicines:

If you accept any other medicines, surely consult with the doctor concerning a possibility of use of drug.

Papaverine the hydrochloride, theobromine, Salsolinum – at the combined use with Dibazolum extends a range of pharmacological action of a papaverine of a hydrochloride, theobromine, Salsolinum.

Barbiturates – at the combined use with Dibazolum efficiency of barbiturates of long action, in particular phenobarbital amplifies.

Phentolamine, hypotensive drugs (the means influencing a renin-angiotenzinovuyu system, etc.), saluretics – at the combined use with Dibazolum amplifies hypotensive effect.

β-blockers - - - - - - - - - – at the combined use about dibazolomgipotenzivny effect of the last does not change, but at prolonged use Dibazolum prevents increase in the general peripheric resistance caused by β-blockers..........

Contraindications:

Hypersensitivity to drug. The diseases proceeding with decrease in a muscle tone, a convulsive syndrome, heavy heart failure. Hypotension. Chronic nephrite with hypostases and disturbance of azotovydelitelny function of kidneys. Stomach ulcer and a duodenum with bleeding. Diabetes mellitus.

Overdose:

Symptoms: hypotension, the increased perspiration, feeling of heat, dizziness, nausea, a slight headache which quickly pass at reduction of a dose or drug withdrawal.

Treatment: at emergence of the specified symptoms it is necessary to see a doctor immediately. Before arrival of the doctor it is recommended to cause vomiting, to wash out a stomach with use of absorbent carbon. Appoint salt laxative. At hypotension the transfusion and symptomatic therapy (vasoconstrictors, cardiac glycosides) is recommended. There is no specific antidote.

Storage conditions:

Period of validity 2 years. Use of drug after the termination of the period of validity specified on packaging is not recommended. To store in the place, unavailable to children, in original packaging at a temperature not above 25 °C.

Issue conditions:

Without recipe

Packaging:

On 10 tablets in a blister strip packaging, on 1 blister strip packaging in a pack; on 10 tablets in blister strip packagings.