Neomidantanum

General characteristics. Structure:

Active вещество:мидантан - 100 mg;

Excipients: paktoza, potato starch, stearic acid.

Pharmacological properties:

Protivoparkinsonichesky and antiviral means, tricyclic symmetric adamantanamine.
Blocks glutamate NMDA receptors and by that reduces the excessive stimulating influence of cortical glutamate neurons on a neostriatum developing against the background of insufficiency of a dopamine. Amantadin oppresses NMDA receptors of neurons of black substance, reduces receipt in them of Ca2+ that reduces a possibility of destruction of the specified neurons. More influences constraint (rigidity and a bradykinesia).
Inhibits penetration of an influenza virus of A into a cell.

Pharmacokinetics. After intake it is completely absorbed from a GIT. Cmax in a blood plasma is reached in 5 h. It is removed with urine. T1/2 of an amantadin of sulfate is 12-13 h, unlike an amantadin of a hydrochloride which T1/2 makes 30 h.

Indications to use:

- Parkinson's disease, parkinsonism syndrome (rigidity, tremor, hypokinesia).
- Neuralgia at the shingles caused by the Varicella zoster virus.
- Prevention (including in combination with vaccination) and treatment of flu A.

Route of administration and doses:

For intake the single dose makes 100-200 mg.
In/in in the form of infusions on 200 mg within 3 hours.
Frequency and duration of use depend on indications, reaction of the patient to treatment, an epidemiological situation.
Maximum dose: at intake - 600 mg/days.

Features of use:

With care apply at patients with renal failures, at simultaneous use with other protivoparkinsonichesky means, and also at elderly people. In such cases correction of the mode of dosing of an amantadin is required. At patients with a hyperreflexia cancellation of treatment should be carried out gradually.
Data on efficiency of an amantadin for reduction of extrapyramidal frustration at treatment by antipsychotic means (medicinal parkinsonism) are contradictory.
During treatment not to allow alcohol intake.

Influence on ability to driving of motor transport and to control of mechanisms
During treatment it is not necessary to be engaged in the types of activity demanding high concentration of attention and bystry psychomotor reactions.

Side effects:

- From TsNS: headaches, a depression, visual hallucinations, motive or a hyperphrenia, spasms, irritability, dizziness, frustration of a dream, the tremor, mental disorders which are followed by visual hallucinations, decrease in visual acuity.
- From cardiovascular system: development or aggravation of heart failure, orthostatic hypotension; seldom - arrhythmia, tachycardia.
- From the alimentary system: seldom - anorexia, nausea, locks, dryness in a mouth.
- From an urinary system: patients with a hyperplasia of a prostate have a difficulty of an urination; polyuria, nocturia.
- Dermatological reactions: dermatosis, emergence of bluish coloring of skin of upper and lower extremities (livedo reticularis).

Interaction with other medicines:

At simultaneous use strengthening of side effect of protivoparkinsonichesky means is possible.
At simultaneous use with thiazide diuretics it is impossible to exclude a possibility of development of toxic effects of an amantadin (an ataxy, excitement, hallucinations) probably owing to reduction of its renal clearance.
The case of acute confusion of consciousness at the patient of advanced age at simultaneous use with co-trimoxazole is described.
At simultaneous use with quinine, quinidine reduction of removal of an amantadin with urine is possible.

Contraindications:

Liver failure, chronic renal failure, psychoses (including in the anamnesis), a thyrotoxicosis, epilepsy, closed-angle glaucoma, a prostate hyperplasia, arterial hypotension, chronic heart failure of the II-III stage, a condition of excitement, a predelirium, delirious psychosis, the I trimester of pregnancy, the lactation period, a concomitant use of Triamterenum and hydrochlorothiazide, hypersensitivity to an amantadin.

Use at pregnancy and feeding by a breast
At pregnancy use of an amantadin is possible only according to strict indications and under observation of the doctor. It is contraindicated in the I trimester of pregnancy.
In case of need uses in the period of a lactation it is necessary to resolve an issue of the breastfeeding termination.

Use at abnormal liver functions
Contraindication: liver failure.

Use at renal failures
It is contraindicated at a chronic renal failure. With care apply at patients with renal failures.

Use for elderly patients
With care apply at elderly people.

Overdose:

Symptoms: increase in pupils which poorly or at all "react to light; ischuria; disturbance of acid-base balance of an organism acute psychosis with a disorientation, visual hallucinations and an agressive behavior disturbance of breath and cardiac arrhythmia. The coma, an apnoea and cordial activity within several hours after overdose is possible. For a delay of absorption of drug carry out a gastric lavage or cause vomiting. Provide maintenance of the vital functions, hydration. For bystry removal of drug I provide acid reaction of urine. Only a small amount of drug is removed by means of a hemodialysis. For reduction of symptoms from TsNS by the adult physostigmine in doses of 1 - 2 mg in/in, as necessary repeatedly, but no more than 2 mg an hour is effective. Apply aminazine to removal of psychoses.

Storage conditions:

To store at a temperature not above +25 °C, in the dry place, unavailable to children. The period of validity is specified on packaging. Not to use drug after the termination of a period of validity.

Issue conditions:

According to the recipe

Packaging:

Capsules on 100 mg in packaging, on 10 and 50 pieces.