Noofen

General characteristics. Structure:

Active is veshchestvo:feninut by 250 mg;

Other components: lactose, potato starch, calcium stearate.

Pharmacological properties:

Pharmacodynamics. Noofen is derivative γ-aminobutyric acid of acid and a feniletilamin. Its anti-hypoxemic and anti-anamnestic action is dominating. Possesses tranquilizing properties, stimulates processes of training and improvement of memory, increases physical working capacity; removes stress, uneasiness, fear and improves a dream; prolongs and strengthens action of somnolent, narcotic, antipsychotic and antiunconscious means. Does not influence on well-cared and adrenoceptors. Drug prolongs stage of latency and reduces duration and expressiveness to a nystagmus, has anti-epileptic action. Noofen considerably reduces manifestations of an adynamy and vazovegetativny symptoms, including a headache, heavy feeling in the head, a sleep disorder, irritability, emotional lability, increases intellectual working capacity. Psychological indicators (attention, memory, speed and accuracy of sensory-motor reactions) under the influence of Noofen improve in a counterbalance influential tranquilizers. At patients with an adynamy and in emotionally labile persons from the first days of therapy by means of Noofen the subjective health improves, interest and an initiative, motivation of activity without undesirable sedation or excitement increases. It is established that Noofen applied after a craniocereberal injury increases quantity of mitochondrions perifokalno and improves brain bio-energetics. In the presence of damages of heart and stomach Noofen normalizes processes of a peroksidation of lipids.

Pharmacokinetics. Drug is well soaked up after oral administration and well gets into all body tissues, well passes through a blood-brain barrier. Distribution in a liver and kidneys it is close to uniform, and in a brain and blood – below uniform. In 3 hours noticeable the quantity of the entered Phenibutum is found in urine, at the same time concentration of drug in tissue of a brain does not decrease, it is found in a brain in 6 hours. Next afternoon Phenibutum can be revealed only in urine; it is found in urine in 2 days after reception, but the quantity is revealed makes only 5% of the entered dose. Most binding of Phenibutum results in a liver (80%), it is not specific. At repeated introduction of cumulation do not observe.

Indications to use:

Lowered intellectual and emotional activity, memory disturbance, decrease in concentration of attention. Asthenic and alarming and neurotic condition, uneasiness, fear, concern, neurosis of persuasive states, psychopathy; children have a stutter, enuresis, a tic; people of advanced age have a sleeplessness, night concern. Appoint for prevention of stressful states, before operations or painful diagnostic testings. As auxiliary drug during treatment of alcoholism for suspension of psychopathological and somatovegetativny disturbances in the presence of an abstinence syndrome. Together with the standard disintoxication means for treatment of alcoholic predeliriozny and delirious states. Menyer's disease, dizziness that connected with dysfunction of a vestibular mechanism, prevention a motion desease.

Route of administration and doses:

Noofen accept inside before food. The course of treatment makes 4-6 weeks. The adult appoint 250-500 mg 3 times a day. In case of need it is possible to increase a daily dose to 2, 5 g (2 500 mg). To children from 3 to 8 years appoint 50-100 mg 3 times a day, from 8 to 14 years – on 250 mg 3 times a day. The highest single doses: for adults – 750 mg, for persons are more senior than 60 years – 500 mg, to children up to 8 years – 150 mg, from 8 to 14 years – 300 mg.

Noofen it is possible to komponirovat with other psychotropic drugs, for increase in its efficiency, and it is possible to reduce Noofen's dose and other drugs which are accepted together with it.

For stopping of an alcoholic abstinence syndrome Noofen, in the first days of treatment, accept 250-500 mg 3 times a day and 750 mg for the night, with gradual decrease in a daily dose to ordinary for adults.

In case of dizzinesses at dysfunction of a vestibular analyzer of infectious genesis (an otogenic labyrinthitis) and at a disease Menyera Noofen apply in the period of an aggravation 750 mg 3 times a day within 5-7 days, at reduction of expressiveness of vestibular disturbances – on 250-500 mg of drug 3 times a day within 5-7 days, and then on 250 mg of 1 times a day within 5 days. At rather easy the course of diseases of Noofen apply 250 mg 2 times a day within 5-7 days, and then on 250 mg of 1 times a day within 7-10 days.

For treatment of dizzinesses at dysfunctions of a vestibular analyzer of vascular and traumatic genesis Noofen appoint 250 mg 3 times a day within 12 days.

For prevention a motion desease in the conditions of sea swimming appoint in a dose 250-500 mg once for an hour till the namerivayemy beginning of rolling at emergence of the first symptoms of a sea sickness. Protizakhituvalna Noofen's action amplifies at increase in a dose of drug. In the presence of the expressed displays of seasickness (vomiting, etc.) Noofen's uses orally is ineffective even in doses of 750-1000 mg.

For prevention of aeroembolism Noofen appoint once in a dose 250-500 mg for an hour before flight.

If one or several times beforehand it was not accepted the next dose, then it is necessary to continue a course of treatment according to with the appointed doses earlier.

Features of use:

Precautionary measures
It is necessary to adhere to care at purpose of drug the patient with digestive tract pathology through irritant action of Noofen. This patient appoint smaller doses.
At prolonged use control morphological composition of blood. It is necessary to control indicators of function of a liver also.

Pregnancy and feeding by a breast
During the periods of pregnancy and feeding the breast does not recommend to use drug as there are no sufficient observations.

Influence on ability to manage vehicles
To patients at whom arise drowsiness dizziness or others disturbance from the central nervous system, during treatment it is impossible to manage transport and to service mechanisms.

Side effects:

After the first receptions or at overdose drowsiness and nausea are possible. If during treatment drug observes the side effects which are not noted in the Instruction for use about it it is necessary to inform the doctor.

Interaction with other medicines:

Noofen it is possible to apply with other medicines, including with psychotropic drugs – tranquilizers and neuroleptics, (action mutually amplifies).

Contraindications:

The increased individual sensitivity to drug.

Overdose:

Noofen – low-toxic connection, only in a daily dose of 7-14 g at prolonged use he can be gepatotoksichny.
Noted doses considerably exceed the recommended dose (an average therapeutic dose – 750-2 500 mg). Only at the highest applied dose observed an eosinophilia and fatty dystrophy of a liver. At use drug in smaller doses of such changes was not.
At poisoning wash out a stomach and provide supports of the vital functions together with symptomatic receptions. In a clinical picture at overdose drowsiness, nausea, vomiting exceeds. At complications (hypotension, a renal failure) use auxiliary and symptomatic actions.

Storage conditions:

To store in the unavailable to children, dry, protected from light place at a temperature of 15 °C - 25 °C.

Issue conditions:

Without recipe

Packaging:

On 10 capsules in the blister. On 2 blisters in a pack.