Комбилипен®

General characteristics. Structure:

Active ingredients: Thiamin a hydrochloride - 100 mg; The Pyridoxine a hydrochloride - 100 mg; Cyanocobalamine - 1,0 mg; Lidocaine a hydrochloride - 20 mg;
 
Excipients: benzyl alcohol, sodium tripolyphosphate, potassium hexacyanoferrate, sodium hydroxide, water for injections to 2 ml.
 
Description. Transparent pinkish-red liquid with a specific smell

Pharmacological properties:

The combined polyvitaminic drug. Effect of drug is defined by properties of the vitamins which are its part. Neurotropic vitamins of group B make favorable impact on inflammatory and degenerative diseases of a nervous system and the motive device.
 
Thiamin the hydrochloride (B1 vitamin) – participates in carrying out nervous impulse.
 
Pyridoxine the hydrochloride (B6 vitamin) – has zhiznennovazhny influence on exchange of proteins, carbohydrates and fats, is necessary for a normal hemopoiesis, functioning of the central and peripheral nervous system. Provides synoptic transfer, processes of braking to TsNS, participates in transport of the sphingosine which is a part of a cover of a nerve participates in synthesis of catecholamines.
 
Cyanocobalamine (B12 vitamin) – participates in synthesis of nucleotides, is an important factor of normal growth, a hemopoiesis and development of epithelial cells; it is necessary for metabolism of folic acid and synthesis of a myelin.
 
Lidocaine has anesthetic effect in the place of an injection, expands vessels, promoting absorption of vitamins. Mestnoanesteziruyushchy effect of lidocaine is caused by blockade of potentsialzavisimy Na+-channels that interferes with generation of impulses in the terminations of sensory nerves and to carrying out painful impulses on nerve fibrils.

Indications to use:

It is applied in complex therapy of the following neurologic diseases:
• epileptiform neuralgia;
• neuritis of a facial nerve;
• the pain syndrome caused by backbone diseases (intercostal neuralgia, a lumbar ishialgia, a lumbar syndrome, a cervical syndrome, a cervicobrachial syndrome, the radicular syndrome caused by degenerative changes of a backbone);
• polyneuropathy of various etiology (diabetic, alcoholic).

Route of administration and doses:

In cases of the expressed pain syndrome treatment is reasonable to begin with intramuscular introduction (deeply) 2 ml daily within 5-10 days with transition further either on intake, or on more rare injections (2-3 times a week within 2-3 weeks) with possible continuation of therapy by a dosage form for intake.

Side effects:

Allergic reactions. In some cases there can be a perspiration, tachycardia, acne rash develops. Skin reactions in the form of an itch, a small tortoiseshell are described; the complicated breath, a Quincke's edema, an acute anaphylaxis.

Interaction with other medicines:

Vitmain of B1 completely breaks up in the solutions containing sulfites is incompatible with the oxidizing and reducing substances: mercury chloride, iodide, carbonate, acetate, tannin acid, iron-аммонийцитратом, and also sodium phenobarbital, Riboflavinum, benzylpenicillin, dextrose and metabisulphite.

The levodopa reduces effect of therapeutic doses of B6 vitamin. B12 vitamin is incompatible with salts of heavy metals, ascorbic acid

Contraindications:

Hypersensitivity to drug components, severe and acute forms of dekompensirovanny heart failure, pregnancy and the period of a lactation, children's age, due to the lack of data.

Use during pregnancy and breastfeeding. Use of drug is not recommended.

Overdose:

Symptoms: dizziness, nausea, vomiting, itch, urticaria; the increased sweating, tachycardia.
Treatment: symptomatic.

Storage conditions:

In the place protected from light at a temperature from 2 °C to 8 °C. To store in the place, unavailable to children. A period of validity - 2 years. Not to use after a period of validity.

Issue conditions:

According to the recipe

Packaging:

Solution for intramuscular introduction.
 • On 2 ml in ampoules import of light-protective glass.
 • On 10 ampoules together with the scarificator ampoule and the application instruction place in a box from a cardboard.
 • On 5 or 10 ampoules in a blister strip packaging from a film polyvinyl chloride or from a film of polietilentereftalatny and aluminum foil or without foil.
 • 1 or 2 planimetric packagings together with the scarificator ampoule and the application instruction place in a pack from a cardboard.
 
When packaging ampoules with notches, rings and points of a break the scarificator ampoule is not put.