Vitakson

General characteristics. Structure:

Active ingredients: thiamin hydrochloride, pyridoxine hydrochloride, cyanocobalamine;

1 ml of solution contains hydrochloride thiamin in terms of 100% anhydrous substance of 50 mg, a hydrochloride pyridoxine in terms of 100% dry matter of 50 mg, cyanocobalamine in terms of 100% dry matter of 0,5 mg;

excipients: lidocaine a hydrochloride, benzyl alcohol, sodium polyphosphate, potassium hexacyanoferrate ІІІ, 1 M hydroxide sodium solution, water for injections.

Pharmacological properties:

Pharmacodynamics. Neurotropic vitamins of group B have positive effect at inflammatory and/or degenerative diseases of nerves and a musculoskeletal system. They are applied to elimination of scarce states, and in high doses have analgeziruyushchy effect, improve blood circulation, normalize work of a nervous system and process of a hemopoiesis.

B1 vitamin is important active agent. In an organism it is phosphorylated with formation of biologically active tiamindifosfat (cocarboxylase) and a tiamintrifosfat (TTR). Tiamindifosfat as coenzyme takes part in important processes of carbohydrate metabolism and in exchange processes of nervous tissue, influences carrying out nervous impulse in synapses. At a lack of B1 vitamin of fabrics there is an accumulation of metabolites, first of all milk and pyroracemic acids that leads to various morbid conditions and disturbances of activity of a nervous system.

B6 vitamin in the fosforilirovanny form (piridoksal-5’ - phosphate, PALP) is coenzyme of a number of the enzymes interacting in the general not oxidizing metabolism of amino acids. By means of decarboxylation they participate in formation of physiologically active amines (for example, adrenaline, a histamine, serotonin, a dopamine, tyramine), by means of transamination — in anabolic and catabolic processes of exchange (for example, a glutamate-oksaloatsetattransaminaza, a glutamatpiruvattransaminaza, piperidic acid, a α-ketoglyutarattransaminaza), and also in various processes of splitting and synthesis of amino acids. B6 vitamin acts on 4 different stages of metabolism of tryptophane. In the course of hemoglobin synthesis B6 vitamin catalyzes formation of α-amino-β-ketoadininovy acid.

B12 vitamin is necessary for processes of cellular metabolism. He influences hemopoiesis function (an external antianemic factor), takes part in formation of sincaline, methionine, creatinine, nucleic acids, has the anesthetizing effect.

Pharmacokinetics. After parenteral administration thiamin is distributed in an organism. About 1 mg of thiamin is metabolized daily. Metabolites are removed with urine. Dephosphorylation happens in kidneys. Biological half-life of thiamin makes 0,35 h. Accumulation of thiamin in an organism does not happen thanks to weak dissolution in fats.

B6 vitamin is phosphorylated and oxidized to piridoksal-5-phosphate. In a blood plasma piridoksal-5-phosphate and пиридоксаль contact albumine. For passing through a cellular membrane the piridoksal-5-phosphate connected with albumine is hydrolyzed by means of an alkaline phosphatase in пиридоксаль.

B12 vitamin after parenteral administration forms transport proteinaceous complexes which are quickly absorbed by a liver, marrow and other bodies. B12 vitamin comes to bile and takes part in enterohepatic circulation. B12 vitamin gets through a placenta.

Pharmaceutical characteristics.

Main physical and chemical properties: transparent liquid of red color with a specific smell.
Incompatibility.

Not to mix with other medicines.

Indications to use:

Neurologic diseases of various origin: neuritis, neuralgia, polyneuropathies (diabetic, alcoholic), mialgiya, radicular syndrome, retrobulbar neuritis, shingles, paralysis of a facial nerve.

Route of administration and doses:

The drug is administered slowly deeply in a muscle.

In hard cases of a disease and at an acute pain for bystry increase in level of vitamins B of blood appoint 2 ml of solution intramusculary 1 time a day. After subsiding of an aggravation and at easy forms of a disease appoint 2 ml 2 - 3 times a week.

The course of treatment lasts not less than 1 month.

Features of use:

Use during pregnancy or feeding by a breast.

Not to use drug during pregnancy or feeding by a breast.
Children.

Safety of use of drug for children is not proved. As solution contains benzyl alcohol, children cannot use drug.

Intramuscular injections of B12 vitamin can become the reason of anaphylactoid reaction at patients with hypersensitivity.

Ability to influence speed of response at control of motor transport or work with other mechanisms. Does not influence speed of response at control of motor transport and work with other mechanisms. Patients at whom after administration of drug dizziness was observed should refrain from control of motor transport or work with other mechanisms.

Side effects:

At very bystry introduction system reactions (dizziness, nausea, arrhythmia, bradycardia, the increased perspiration, spasms) which quickly take place are possible.

Allergic reactions: skin rash and/or an itch, the complicated breath, a Quincke's edema, an acute anaphylaxis.

In isolated cases – the increased perspiration, acne rash, a small tortoiseshell.

Interaction with other medicines:

Thiamin completely breaks up at interaction with the solutions containing sulfates. In the presence of B1 vitamin decomposition products other vitamins can be inactivated.

At use together with the drugs containing a levodopa peripheral decarboxylation of a levodopa amplifies and its antiparkinsonichesky action decreases.

Contraindications:

The increased individual sensitivity to drug components;
acute form of dekompensirovanny heart failure;
acute disorder of cordial conductivity;
psoriasis;
pregnancy and period of feeding by a breast;
children's age.

Overdose:

Symptoms: strengthening of manifestations of side effect - dizziness, nausea, arrhythmia, bradycardia, the increased perspiration, spasms.

Treatment: symptomatic therapy.

Storage conditions:

Period of validity. 2 years. Not to use drug after the termination of the period of validity specified on packaging. To store in the place protected from light at a temperature not over 15 ºС. To store in the place, unavailable to children.

Issue conditions:

According to the recipe

Packaging:

On 2 ml in an ampoule. On 5 or 10 ampoules enclosed in a pack.