Nandrolonum D

General characteristics. Structure:

Active ingredient: 50 mg, 100 mg or 200 mg of Nandrolonum of a dekanoat in 1 ml of solution.

Excipients: benzyl alcohol, benzyl benzoate, oil peach.

Synthetic derivative testosterone with the androgenic, but strengthened anabolic effect weakened.

Pharmacological properties:

Pharmacodynamics. The anabolic effect is shown by activation of reparative processes in an epithelium (cover and ferruterous), bone and muscular fabrics as a result of stimulation of synthesis of protein and structural components of cells. Increases completeness of absorption of amino acids from a small bowel (against the background of the diet rich with proteins), creating positive nitrogenous balance. Stimulates production of erythropoetin and activates anabolic processes in marrow that at co-administration of iron preparations is shown by antianemic action. Synthesis of gonadotrophins and endogenous testosterone oppresses. In high doses the spermatogenesis oppresses. Growth and sexual development of children can detain.

Vitamin of K-dependent plasma blood-coagulation factors breaks synthesis (II, VII, IX, X) in a liver, the lipidic profile of plasma changes (increases concentration of LPNP and reduces the maintenance of LPVP), strengthens a reabsorption of sodium and water in kidneys, promoting formation of peripheral hypostases. These effects disappear after the reception termination.

Pharmacokinetics. After introduction in oil 100 mg of Cmax are created in 1–3 weeks. Is exposed to biotransformation in a liver with formation of 17 ketosteroids. Also about 6% — with excrements are removed generally with urine (over 90%).

Indications to use:

Treatment of anemia at a renal failure (raises a hemoglobin content and cellular weight), a diabetic retinopathy, a myodystrophy, spinal amyotrophy of Verdinga-Goffmann, a breast cancer (supportive application), a glomerulonephritis, extensive burns, osteoporosis.

Route of administration and doses:

In oil,  deeply.

At anemia (along with iron preparations) — 100–200 mg (to women — 50–100 mg) once a week; for stimulation of anabolic processes — 50–200 mg (to women — 50–100 mg) 1 time in 1–4 weeks; children are 2–13 years old — 0,4 mg/kg of 1 times in 3–4 weeks. Course duration (at a 1-4 weeks interval between injections) — to 12 weeks, a repeated course — in 8 weeks after the last injection of drug. Treatment is carried out against the background of a protein-rich diet.

Features of use:

At emergence of the first signs of virilescence in women (voice coarsening, a hirsutism, eels, a clitoromegaly), reception should be stopped not to allow irreversibility of changes. There can come suppression of factors II, VII, IX and X fibrillation and increase in a prothrombin time. To periodically check the level of a lipidemiya and cholesterinemia. To children drug has to be appointed by the experienced specialist not to allow premature ossification of an epiphysis of bones.

Side effects:

Women have virilescence symptoms, oppression of function of ovaries, frustration of a menstrual cycle, a hypercalcemia.

At men: in the prepubertatny period — virilescence symptoms, an idiopathic hyperpegmentation of skin, delay or the termination of growth (calcification of epiphyseal growth zones of tubular bones); in the post-pubertal period — irritation of a bladder, a gynecomastia, a priapism; at advanced age — a hypertrophy and/or a carcinoma of a prostate.

Men and women have a progressing of atherosclerosis, peripheral hypostases, dispeptic frustration, disturbance of functions of a liver with jaundice, changes in a leukocytic formula, long tubular bone pain, hypocoagulation with bent to bleedings.

Interaction with other medicines:

Glucocorticoids, mineralokortikoida, corticotropin, natriysoderzha-shchy drugs and the food rich with sodium exponentiate a liquid delay in an organism, increase risk of development of hypostases, increase expressiveness of acne rashes. Strengthens effects of antiagregant, indirect anticoagulants, insulin and peroral antidiabetic means weakens – STG and its derivatives.

Contraindications:

Hypersensitivity to drug, a prostate cancer, a breast cancer at men, a carcinoma of a mammary gland at women with a hypercalcemia, an ischemic heart disease, the expressed atherosclerosis, a nephrotic syndrome, acute and chronic diseases of a liver, including alcoholic defeats, nephrite, pregnancy, feeding of a breast.

Overdose:

Cases of overdose are not registered.

Storage conditions:

To store at a temperature of 15-25 °C, in dry, protected from light and the place, unavailable to children. Period of validity of 5 years. Not to use after the expiry date specified on packaging.

Issue conditions:

According to the recipe

Packaging:

Solution for injections of oil 5%, 10% and 20% on 1 ml or 2 ml in ampoules or solution of 5% and 10% on 2 ml, 5 ml or 10 ml and 20% on 2 ml or 5 ml in bottles.