Piracetam of 12%

General characteristics. Structure:

Active ingredient: 120 g of piracetam.

Excipients: sodium acetate 3-water, acid solution acetic divorced to рН 5,0 - 6,0, water for injections.

Piracetam directly influences a brain, improving cognitive (cognitive) processes, such as ability to training, memory, attention, and also intellectual working capacity.

Pharmacological properties:

Pharmacodynamics. Piracetam is the main representative of group of nootropic drugs. At introduction to an organism gets into different bodies and fabrics, including into brain tissues. Piracetam directly influences a brain, improving cognitive (cognitive) processes, such as ability to training, memory, attention, and also intellectual working capacity.

Exerts positive impact on exchange processes and blood circulation of a brain. Stimulates oxidation-reduction processes, strengthens glucose utilization, improves a regional blood stream in ischemic sites of a brain. Improvement of power processes under the influence of piracetam leads to increase in stability of tissues of brain at a hypoxia and toxic influences. Drug малотоксичен. Has no sedative and psychogogic effect.

Pharmacokinetics. Absorption. At intake it is quickly and almost completely absorbed from a GIT. Cmax is reached approximately in 30-60 min., the peak of concentration in cerebrospinal fluid - in 2-8 h. Bioavailability of piracetam is close to 100%. Distribution of Vd makes 0.6 l/kg. Does not contact proteins of a blood plasma. It is distributed in all bodies and fabrics, gets through GEB. Selectively collects in tissues of a cerebral cortex, it is preferential in frontal, parietal and occipital lobes, in a cerebellum and basal gangliya. Gets through a placental barrier, it is allocated with breast milk.

Metabolism. Piracetam is not metabolized in a human body.

Removal. T1/2 of a blood plasma makes 4-5 h, an elimination half-life of cerebrospinal fluid - 6-8 h. It is removed preferential with urine in not changed look. During 24-30 h after a single dose 90-100% of the accepted dose are allocated. About 1-2% of the dose of drug accepted inside are removed with a stake.

Indications to use:

Memory disturbance, dizziness, decrease in concentration of attention, emotional lability, dementia owing to disturbances of cerebral circulation, brain injuries; at Alzheimer's disease at advanced age; comas of vascular, traumatic or toxic genesis; treatment of abstinence and psychoorganic syndrome at an alcoholism; a sickemia (as a part of a combination therapy).

Route of administration and doses:

Drug is used intravenously or intramusculary. For children the dose makes 30-50 mg/kg of mass of bodies/days in 2-3 receptions. It is necessary to continue treatment not less than 3 weeks. For adults the dose makes 30-160 mg/kg of mass of bodies/days in 2-4 receptions. It is necessary to continue treatment 6-8 weeks.

At intravenous administration in serious conditions the daily dose of piracetam can make 12 g. After clinical improvement the dose is gradually reduced and passed to intake.

Features of use:

Patients with renal failures need regular medical control and constant observation. At patients of advanced age before purpose of drug it is necessary to investigate function of kidneys carefully. Piracetam reduces a threshold of convulsive readiness that increases risk of its use at epilepsy. At such patients it is necessary to carry out dose adjustment of antiepileptic means even if the positive take remains.

Care is necessary and at treatment of patients with a hyperthyroidism, and also at purpose of hormones of a thyroid gland. Treatment by piracetam is stopped gradually. With care to appoint piracetam at the same time with TsNS stimulators, with neuroleptics, with drugs of hormones of a thyroid gland.

Influence on ability to driving of motor transport and to control of mechanisms. At use of piracetam there is no need to set restrictions for driving of the vehicles, control of mechanisms or performance of work connected with the increased risk.

Pregnancy. Use is possible only in cases when the estimated advantage for mother surpasses possible risk of a fruit.

Lactation. In need of use in the period of a lactation it is necessary to resolve an issue of the breastfeeding termination.

Side effects:

From the alimentary system: seldom – the dispepsichesky phenomena, abdominal pains.

From TsNS: seldom – excitement, irritability, concern, frustration of a dream, dizziness, a headache, a tremor; in certain cases – weakness, drowsiness.

Interaction with other medicines:

At simultaneous use of piracetam with stimulators of TsNS strengthening of psychogogic action is possible.

At simultaneous use with neuroleptics strengthening of extrapyramidal frustration is observed.

At simultaneous use with drugs of hormones of a thyroid gland emergence of the central effects - a tremor, concern, irritability, frustration of a dream, confusion of consciousness is possible.

Contraindications:

Heavy renal failure (at KK less than 20 ml/min.), hypersensitivity to piracetam, pregnancy, the lactation period.

Overdose:

Symptoms: even at use in high doses piracetam does not cause toxic effects. However at overdose strengthening of side effects is possible.

Treatment: symptomatic therapy is carried out.

Storage conditions:

List B. In the dry, protected from light place at a temperature from +15 °C to +25 °C. Period of validity 2 years.

Issue conditions:

According to the recipe

Packaging:

On 100 ml or 250 ml in polymeric containers packages.