Hexamidine

General characteristics. Structure:

Active ingredient: 0,125 g or 0,25 g of a hexamidine.

Excipients: potato starch, sodium glikolit starch, polyvinylpirrolidone like "Kollidon 90 F", calcium stearate.

Pharmacological properties:

Pharmacodynamics. On a chemical structure it is close to phenobarbital, but differs in what possesses stronger anticonvulsant action, without having the systemic oppressing effect on the central nervous system and the expressed somnolent effect.

Pharmacokinetics. At intake the hexamidine quickly and almost is completely soaked up. The peak of concentration in a blood plasma is observed approximately in 3 hours. The elimination half-life in plasma makes 7-14 hours. Drug is metabolized with formation of active metabolites - phenobarbital and a feniletilmalonamid. To 40% of drug it is allocated in not changed view with urine.

Indications to use:

Epilepsies, big convulsive attacks. Is less effective at slight abortal attacks and mental equivalents. At small forms has no constant effect, however the therapeutic effect is in some cases observed.

Route of administration and doses:

Drug is appointed inside after food. An initial daily dose for adult 0,125 g a day (in 1-2 receptions), then each 3 days increase a daily dose by 0,25 g a day - before achievement of necessary effect. The maximum daily dose for adult 2 g, one-time 0,75 g.

To children depending on age appoint from 0,125 g to 0,5 g a day.

Features of use:

Drug is used only on doctor's orders. At emergence of unusual reactions tell the doctor.

It is necessary to be careful during the work with mechanisms.

Side effects:

In the first days of treatment by a hexamidine drowsiness, dizziness, a headache, an ataxy, nausea are possible. These phenomena usually pass independently.

At long reception are possible:
- from a nervous system: apathy, uneasiness, psychotic reactions; nystagmus (seldom);
- from system of a hemopoiesis: leukopenia, lymphocytosis, anemia;
- others: volchanochnopodobny syndrome, arthralgia; medicinal dependence; deficit of folic acid;
- allergic reactions.

Interaction with other medicines:

The hexamidine strengthens action of hypnagogues, derivative sulphonylurea, cyclophosphamide, a methotrexate.

Increasing activity of microsomal enzymes of a liver, it accelerates biotransformation of derivatives of coumarin, oestrogenic contraceptives, griseofulvin, doxycycline.

At co-administration of drugs - stimulators of microsomal enzymes of a liver: phenobarbital, carbamazepine, rifampicin, ethanol (at the chronic use) metabolism of a hexamidine accelerates and its efficiency decreases.

Contraindications:

- hypersensitivity to drug;
- abnormal liver function or kidneys;
- diseases of system of a hemopoiesis;
- pregnancy and lactation.

With care - children's and advanced age (perhaps paradoxical and motive excitement).

Overdose:

At overdose of a hexamidine there are dizziness, nausea, an ataxy, TsNS function oppression.

First aid: gastric lavage, purpose of absorbent carbon. If necessary symptomatic therapy in the conditions of a hospital.

Storage conditions:

List B. In the dry place, at a temperature not above 25 °C. To store in the places unavailable to children. Not to use after the period of validity specified on packaging. A period of validity - 5 years.

Issue conditions:

According to the recipe

Packaging:

Tablets on 0,125 and 0,25 g, on 10 tablets in a planimetric strip packaging; 10, 20, 30, 40, 50 and 400 tablets in banks of orange glass. Each can on 10, 20, 30, 40 or 50 tablets or on 1, 2, 3, 4 or 5 blister strip packagings together with the application instruction is placed in a pack from a cardboard.