Febritset

General characteristics. Structure:

Active agents: paracetamol of 500 mg; pheniramine maleate of 25 mg; ascorbic acid of 200 mg

excipients: citric acid anhydrous; изомальт; sodium saccharin; aroma lemon honey; silicon dioxide colloid anhydrous.

Pharmacological properties:

The combined drug.
Paracetamol possesses analgetic and febrifugal action.

Pheniramine - H1 blocker - histamine receptors, reduces a rhinorrhea and dacryagogue, eliminates the spastic phenomena.

Ascorbic acid participates in regulation of oxidation-reduction processes, carbohydrate metabolism, coagulability of blood, an angenesis, in synthesis of steroid hormones; reduces vascular permeability, reduces the need for B1, B2, A, E vitamins, folic acid, pantothenic acid. Improves portability of paracetamol and extends its action (it is connected with lengthening of T1/2).

Indications to use:

— SARS (symptomatic therapy);
— allergic rhinitis;
— nasopharyngitis;
— pain syndrome (weak and moderate expressiveness): arthralgia, mialgiya, neuralgia, migraine, tooth and headache, альгодисменорея;
— pain at injuries, burns.

Route of administration and doses:

Inside, the adult (the dosage form intended to adults) - on 1 pack ice. 2-3 times/days.
To children (children's dosage form) of 6-10 years - on 1 pack ice. 2 times/days, 10-12 years - on 1 pack ice. 3 times/days, 12-15 years - on 1 pack ice. 4 times/days. An interval between receptions - not less than 4 h.
At HPN (KK of 10 ml/min.) an interval between receptions - 8 h.

Features of use:

At the hyperthermia proceeding more than 3 days and a pain syndrome - more than 5 days consultation of the doctor is required.
Distorts indicators of laboratory researches at quantitative definition of glucose and uric acid in plasma.
During treatment control of a picture of peripheral blood and a functional condition of a liver is necessary.
During treatment it is necessary to abstain from the ethanol use (possibly development of a hepatotoxic action).

Influence on ability to driving of motor transport and to control of mechanisms
During treatment it is necessary to abstain from driving of motor transport and occupations other potentially dangerous types of activity demanding the increased concentration of attention and speed of psychomotor reactions.

Side effects:

Allergic reactions (skin rash, itch, small tortoiseshell, Quincke's disease), nausea, epigastric pain; anemia, thrombocytopenia; dryness in a mouth, accommodation paresis, an ischuria, drowsiness.
At prolonged use in high doses - a hepatotoxic action, hemolitic anemia, aplastic anemia, a methemoglobinemia, a pancytopenia; erosive cankers of a GIT, bleeding in a GIT; nephrotoxicity (papillary necrosis).

Interaction with other medicines:

Ethanol strengthens sedative effect of antihistaminic medicines.
Antidepressants, protivoparkinsonichesky, antipsychotic medicines (derivatives of a fenotiazin) increase risk of development of side effects (an ischuria, dryness in a mouth, locks).
GKS increase risk of development of glaucoma.
Inductors of a microsomal oxidation (Phenytoinum, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase products of hydroxylated active metabolites, increasing risk of development of heavy intoxications at small overdoses.
Inhibitors of a microsomal oxidation (Cimetidinum) reduce risk of a hepatotoxic action.
Paracetamol reduces efficiency of uricosuric medicines.

Contraindications:

— hypersensitivity;
— portal hypertensia;
— alcoholism;
— pregnancy (I and III trimesters);
— lactation period.

With care: inborn hyperbilirubinemias (Gilbert's syndromes, the Cudgel Johnson and the Rotor), children's age (up to 15 years - for the dosage form intended to adults), children's age (up to 6 years - for a children's dosage form), closed-angle glaucoma, a prostate hyperplasia, a renal failure, deficit glyukozo-6-fosfatdegidrogenazy.

Drug PARACETAMOL use + PHENIRAMINE + ASCORBIC ACID at pregnancy and feeding by a breast
Contraindications: pregnancy (I and III trimesters); lactation period.

Use at renal failures
With care: renal failure.
At HPN (KK of 10 ml/min.) an interval between receptions - 8 h.

Use for children

With care: children's age (up to 15 years - for the dosage form intended to adults), children's age (up to 6 years - for a children's dosage form).

To children (children's dosage form) of 6-10 years - on 1 pack ice. 2 times/days, 10-12 years - on 1 pack ice. 3 times/days, 12-15 years - on 1 pack ice. 4 times/days. An interval between receptions - not less than 4 h.

Overdose:

Symptoms (are caused by paracetamol): pallor of integuments, loss of appetite, nausea, vomiting; гепатонекроз (expressiveness of a necrosis owing to intoxication directly depends on extent of overdose). Toxic action at adults perhaps after reception over 10-15 g of paracetamol: increase in activity of hepatic transaminases, increase in a prothrombin time (in 12-48 h after reception); the developed clinical picture of damage of a liver is shown in 1-6 days. Seldom liver failure develops immediately and can be complicated by a renal failure (a tubular necrosis).

Treatment: in the first 6 h after overdose - a gastric lavage, introduction of donators of SH-group and predecessors of synthesis of glutathione - methionine in 8-9 h after overdose and N-Acetylcysteinum in 12 h.
Need for holding additional therapeutic actions (further administration of methionine, in/in introduction of N-Acetylcysteinum) is defined by concentration of paracetamol in blood, and also time which passed after its reception.

Storage conditions:

In the dry place, at a temperature of 15-25 °C.
To store in the place, unavailable to children.

Issue conditions:

Without recipe

Packaging:

Powder for пригот. solution for intake of 500 mg +25 mg +200 mg / 4: pack ice. 8 pieces.

Powder for пригот. solution for intake with sugar of 500 mg +25 mg +200 mg / 1 a pack ice.: pack ice. 6, 9 or 12 pieces.

Powder for пригот. solution for intake of lemon 500 mg +25 mg +200 mg / 1 a pack ice.: pack ice. 4.95 of 6, 8, 12 or 16 pieces.

Powder for пригот. solution for intake of 280 mg +10 mg +100 mg / 1 a pack ice.: pack ice. 3 g of 6 or 8 pieces.

Powder for пригот. solution for intake (lemon with sugar) 500 mg +25 mg +200 mg / 1 a pack ice.: pack ice. 13.1 of 6 or 8 pieces.

Powder for пригот. solution for intake (crimson with sugar) 500 mg +25 mg +200 mg / 1 a pack ice.: pack ice. 12.75 of 4, 5, 6 or 8 pieces.