Chymotrypsin

General characteristics. Structure:

Active ingredient: 10 mg of chymotrypsin.

The fermental drug received from a pancreas of cattle and having proteolytic (nekrolitichesky), the antiinflammatory and stimulating regeneration mechanism of medical action.

Pharmacological properties:

Pharmacodynamics. Gidraliziruyet of a squirrel and peptones with formation otnositeno of nizkomeolekulyarny peptides, splits the bonds formed by the remains of aromatic amino acids (tyrosine, tryptophane, phenylalanine, methionine).

Proteolytic means of the proteinaceous nature, has antiinflammatory effect, at topical administration splits nekrotizirovanny fabrics and fibrinous educations; liquefies a viscous secret, exudate, clots.

In relation to healthy fabrics enzyme is not active and safe.

Indications to use:

Thrombophlebitis, periodontosis (inflammatory and dystrophic forms), osteomyelitis, antritis, otitis, iritis, iridocyclitis, intrakapsulyarny extraction of a cataract, hemorrhage in an anterior chamber of an eye, hypostasis of periorbital area after operations and injuries, tracheitis, bronchitis, a pleura empyema, exudative pleurisy, burns, purulent wounds, decubituses (apply locally).

Route of administration and doses:

At treatment of burns and decubituses Chymotrypsin in a dose of 20 mg is dissolved in 20 ml
0,25% of solution of Procainum and a fine needle are entered by several pricks under a scab.

On purulent wound surfaces impose the sterile napkins moistened with solution of 25 - 50 mg of Chymotrypsin in 10-50 ml of 0,25% of solution of Procainum for 8 hours.

For treatment of purulent wounds intramuscular administrations of drug combine with topical treatment of a wound the tampons moistened 5% with aqueous solution of Chymotrypsin.

At thrombophlebitises drug is appointed intramusculary on 5-10 mg daily within 7-10 days.

At extraction of a cataract Chymotrypsin in cultivation 1:5000 is entered into a back chamber of the eye with the subsequent washing of an anterior chamber of an eye of 0,9% chloride sodium solution in 4 minutes after administration of drug.

At treatment of thromboses of the central vein of a retina, acute impassability of the central artery of a retina Chymotrypsin is entered subkonjyuktivalno on 0,2 ml of 5% of the solution prepared for 1% Procainum solution, 1-2 times a week.

At sinusitis the drug is administered in the corresponding cavity in number of 5-10 mg in 3-5 ml of 0,9% of solution of sodium of chloride after a puncture and washing of a cavity.

At otitises dig in in an ear on 0,5-1 ml 0,1% of solution of Chymotrypsin for 0,9% chloride sodium solution. At ear microoperations for a softening of fibrinous educations on average to fish soup during operation enter into a cavity 0,1% Chymotrypsin solution. At the same time it is necessary to enter Chymotrypsin intramusculary on 2,5-5 mg 1-2 times a day. Drug gets divorced in 1-2 ml of 0,25-0,5% of solution of Procainum or 0,9% of solution of sodium of chloride for injections.

Features of use:

It is impossible to enter into the bleeding cavities, to apply on ulcerated surfaces of malignant tumors.

Any influences on the speed of reactions and on ability of management of vehicles are noted.

There are no data on use during a lactation and pregnancy.

Side effects:

Allergic reactions, increase in an emperatura of a body to subfibrilny, tachycardia are possible.

After inhalation introduction hoarseness of a voice and some irritation of mucous membranes of upper respiratory tracts is possible.

At subconjunctival introduction the irritation and puffiness of a conjunctiva is possible (it is necessary to reduce concentration of drug).

After intramuscular introduction the hyperemia and a rzdrazheniye in an injection site are possible.

Interaction with other medicines:

At simultaneous use with iron preparations iron absorption reduction is possible. 

Contraindications:

Hypersensitivity, malignant new growths, dekompensirovanny forms of a pulmonary tuberculosis, heart failure of the II-III stage, cirrhosis, infectious hepatitis, pancreatitis, hemorrhagic diathesis, emphysema of lungs, respiratory insufficiency.

Overdose:

There are no data on overdose.

Storage conditions:

To store at a temperature not above 20 degrees Celsius in protected from light the place. To protect from children!

Issue conditions:

According to the recipe

Packaging:

On 10 mg of drug in the bottles of 5 ml corked by rubber bungs and rolled by aluminum caps. On 10 bottles in a cardboard box with the instruction.