Adaptol

General characteristics. Structure:

Active ingredient: тетраметилтетраазабициклооктандион 500 mg.

Excipients: methyl cellulose - 3.3 mg, calcium stearate - 1.7 mg.

Pharmacological properties:

Anxiolytic (tranquilizer). Adaptol is close on chemical structure to natural metabolites of an organism - its molecule consists of two metilirovanny fragments of urea which are a part of bicyclic structure.
Adaptol affects activity of the structures entering a limbiko-reticular complex, in particular, on emotsiogenny zones of a hypothalamus, and also has effect on all 4 main neuromediator systems: GABA-, sincaline - serotonin - and adrenergic, promoting their balance and integration, but has no peripheral adrenoceptor blocking effect.
Eliminates or weakens concern, alarm, fear, internal emotional pressure and irritability. The calming effect is not followed by muscle relaxation and a lack of coordination of movements.
Does not reduce an intellectual and physical activity therefore Adaptol it is possible to apply during the working day or study. Does not create high spirits, feeling of euphoria.
Has no somnolent effect, but strengthens action of hypnagogues and improves a current of a dream at its disturbances.
Adaptol facilitates or removes nicotinic abstinence.
Except calming has nootropic effect. Adaptol improves cognitive functions, attention and intellectual working capacity, without stimulating symptoms of productive psychopathological frustration - nonsense, pathological emotional activity.

Pharmacokinetics.
Absorption. After intake Adaptol is well soaked up from a GIT (77-80%). Cmax of active agent in a blood plasma is reached in 0.5 h after administration of drug. High concentration of active agent remains during 3-4 h, then gradually decreases.

Distribution. To 40% of the accepted dose contacts erythrocytes. Other part does not contact proteins of plasma and is in a blood plasma in a free look therefore active agent is freely distributed on an organism and freely overcomes cellular membranes.

Metabolism. Active agent is not metabolized and does not collect in an organism.

Removal. About 55-70% of the accepted dose are brought out of an organism with urine, other part — with a stake in not changed look within a day.

Indications to use:

— neurosises and neurosis-like states (irritability, emotional instability, alarm and fear);
— for improvement of portability of neuroleptics and tranquilizers for the purpose of elimination of the somatovegetativny and neurologic side effects caused by them;
— the cardialgia of various genesis (which is not connected with an ischemic heart disease);
— nicotinic abstinence (as a part of complex therapy as the means reducing an inclination to tobacco smoking).

Route of administration and doses:

It is necessary to accept drug inside irrespective of meal on 500 mg 2-3 Maximum single dose makes 3 g, daily - 10 g. Duration of a course of treatment - from several days to 2-3 months.
In complex therapy as the means reducing an inclination to tobacco smoking appoint on 500-1000 mg 3 within 5-6 weeks.

Features of use:

At decrease in the ABP and/or body temperature (it is possible on 1-1.5 °C) the ABP does not need to stop administration of drug. And body temperature are normalized independently.
At emergence of allergic reactions use of drug should be stopped.
Accustoming, dependence (mental and physical) and a withdrawal to Adaptol are not established.

Influence on ability to driving of motor transport and to control of mechanisms
Drug is capable to cause decrease in the ABP and weakness that can negatively affect ability to control of vehicles and work with mechanisms. It is necessary to be careful at use for the patients who are engaged in potentially dangerous types of activity.

Side effects:

Seldom: dizziness, decrease in the ABP, dispeptic symptoms, allergic reactions (skin rash, itch).
At use in high doses: bronchospasm, fall of temperature of a body, weakness.

Interaction with other medicines:

Perhaps simultaneous use of Adaptol with neuroleptics, tranquilizers (benzodiazepines), hypnagogues, antidepressants and psychostimulants.

Contraindications:

— pregnancy;
— period of a lactation (breastfeeding);
— hypersensitivity to drug components.

Use of drug ADAPTOL at pregnancy and feeding by a breast
Use of drug at pregnancy and in the period of a lactation (breastfeeding) is contraindicated.

Overdose:

Drug малотоксичен. The typical clinical picture of overdose is absent. Displays of a serious poisoning are not registered.
Symptoms: weakness, arterial hypotension, dizziness are possible.

Treatment: at suspicion on overdose it is necessary to carry out a gastric lavage, symptomatic therapy.

Storage conditions:

Drug should be stored in unavailable to children, the dry place, at a temperature not above 25 °C. A period of validity - 4 years.

Issue conditions:

According to the recipe

Packaging:

Tablets of white or almost white color, round, ploskotsilindrichesky, with a facet and risky.
10 - planimetric strip packagings (2) - packs cardboard.