Sodium fluoride

General characteristics. Structure:

Active ingredient: 1,1 mg or 2,2 mg of sodium of fluoride.

Excipients with an orange flavor of 2,2 mg: Mannitolum, aspartame, silicon dioxide, magnesium stearate, starch corn, orange flavoring additive, dye yellow "sunset" (E110).

Excipients of 1,1 mg: lactoses monohydrate, calcium stearate, potato starch.

Drug, has trophic, anticaries and antirachitic effect.

Pharmacological properties:

Pharmacodynamics. Sodium fluoride is anticaries prophylactic (especially at children and teenagers). Fluorine ions directly influence processes of a mineralization of solid tissues of teeth during their development. Additional administration of fluorine provides education in tissues of teeth of the steadiest form of apatites - fluorapatite. Besides, fluorine promotes decrease in cariogenic activity of a dental plaque. Brakes lactification from carbohydrates.

Pharmacokinetics. Absorption at intake - 93-97%. The maximum concentration collects in 4 hours. At any dose of 50% of fluorine collects in solid tissues of tooth and bone tissue. Accumulation in bodies or soft tissues was not found. It is removed by kidneys (the fluoride which is not participating in process of an osteogenesis).

Indications to use:

Sodium fluoride appoint for prevention of caries of teeth at children aged from 2 up to 14 years in areas where the content of fluorine in drinking water does not exceed 0,5 mg/l.

Route of administration and doses:

The tablet is held in a mouth before full dissolution (before going to bed after toothbrushing). To children from 2 to 5 years — on 1,1 mg/days, 5 years — on 2,2 mg/days are more senior. It is effective at regular and long reception. A course of treatment — not less than 250 days a year, annually — up to 14 years.

Features of use:

Children up to 10 years should not appoint more than 1 mg/days (probability of development of a ftoroz of teeth) in a dose. Use for children up to 6 years demands special control.

During use of drug it is necessary to conduct annually x-ray examination of lateral departments of a backbone for the purpose of assessment of success of the carried-out therapy and the solution of a question of treatment continuation, and also for early identification of a fluorosis.

Increase in the ShchF level in blood serum is regarded as the beginning of effect of the carried-out therapy. It is necessary to provide receipt of 1-1,5 g/days of calcium for achievement of an adequate mineralization of a bone tissue. In addition appointed drugs of calcium and magnesium have to be accepted to or along with sodium by fluoride.

Osteomalacy is not the indication for drug use. Regular performing blood tests is required from patients with a blood disease during treatment.

Side effects:

Nausea, vomiting, loss of appetite, increased fatigue, headache, diarrhea, arthralgia (especially in ankle, knee and hip joints - up to temporary inability to move); an osteosclerosis, ossification of places of an attachment of sinews and sheaves, a hypothyroidism (at prolonged use), allergic reactions, rhinitis, an eosinophilia, skin rash, a fluorosis (disturbance of process of formation and calcification of enamel, emergence of yellow, brown spots, ispeshchrennost, increase in fragility and erasability of teeth).

Interaction with other medicines:

The effect is reduced by antacids (prematurely dissolve a cover); it is recommended to apply them not earlier than for 2 h before fluoride sodium reception.

At simultaneous introduction of Ca2+, Mg2+, Al3 + absorption of F is slowed down and badly soluble compounds are formed.

Vitamins A and D promote development of ectopic calcification.

Contraindications:

Hypersensitivity, hypothyroidism, peptic ulcer of a stomach and duodenum (in an aggravation stage), a liver and/or renal failure, pregnancy, the lactation period, children's age up to 6 months, 3 years, 6 or 16 years (depending on a dosage form and a dose). Accommodation at areas with the sufficient content of fluoration of water (it is higher than 0,7 mg/l).

Drug contains lactose - patients cannot accept with inborn galaktozny intolerance, deficit of lactase, glucose galactose malabsorption.

Overdose:

Dacryagogue, hypersalivation, nausea, loss of appetite, vomiting, diarrhea, abdominal pain, pains vnizhny extremities, arthralgia, increased fatigue, miosis, vision disorder, weakness, myasthenia, tremor, spasms, fervescence, takhikarliya, lowering of arterial pressure, respiratory insufficiency, apnoea.

As medical measures enter a large amount of liquid and calcium (solution of calcium of a gluconate, lactate calcium, milk) for sedimentation of fluorides; a gastric lavage the acidified water or 1% sodium of chloride, purpose of salt laxatives, in/in administration of electrolytes, vitamins; symptomatic therapy, control of concentration of calcium in blood; hemodialysis.

Storage conditions:

To store in places, unavailable to children, at a temperature not above 25 degrees Celsius.

Issue conditions:

According to the recipe

Packaging:

On 10 tablets in a blister strip packaging from PVC and aluminum. On 3 strip packagings in a cardboard box.

On 250 tablets in a bottle from plastic and in cardboard packaging.