Enterofuril

General characteristics. Structure:

1 capsule contains:
Active ingredients: нифуроксазид 100,0 / 200,0 mg
Excipients: mg sucrose 36,00 / 71,00, starch corn 44,00 / 68,00 mg, cellulose of microcrystallic 5,10/9,0 mg, magnesium mg stearate 0,19/2,0.
Structure of the capsule (100 mg): gelatin, titanium dioxide, dye quinolinic yellow, dye azoruby, dye crimson [Ponso 4R];
Structure of the capsule (200 mg): gelatin, titanium dioxide, dye ferrous oxide yellow.

Description. Solid gelatin opaque capsules of yellow color No. 2 (the capsule of 100 mg) and No. 0 (the capsule of 200 mg) filled with powder of yellow color, or powder of yellow color with inclusions in the form of small pieces of the pressed weight or the pressed powder of yellow color which is scattered by easy pressing.

Pharmacological properties:

Pharmacodynamics. Antimicrobic broad-spectrum agent, derivative 5 nitrofurans.
It is supposed that antimicrobic activity of a nifuroksazid is caused by existence in its structure of NO2 group which causes oppression of activity of a dehydrogenase and breaks protein synthesis in pathogenic bacteriums.
It is active concerning gram-positive microorganisms (Streptococcus aureus, Staphylococcus pyogenes, Clostridium), gram-negative enterobakteriya (Escherihia coli, Salmonella spp., Shigella spp., Klebsiella spp., Enterobacter spp., Vibrio cholerae, Campylobacter jejuni, Edwarsiella, Citrobacter, Yersinia enterocolitica).
Nifuroksazid has no effect on saprophytic flora, does not break balance of a normal indestinal flora. At acute bacterial diarrhea recovers эубиоз intestines. At infection with enterotropic viruses interferes with development of bacterial superinfection.

Pharmacokinetics. After oral administration нифуроксазид it is practically not soaked up from a digestive tract, and has the antibacterial effect only in an intestines gleam. It is completely removed through digestive tract. Speed of elimination depends both on a drug dose, and on motility of an intestinal path.

Indications to use:

Diarrhea of bacterial genesis.

Route of administration and doses:

It is applied inside.
Capsules of 100 mg:
Adults and children are more senior than 7 years: on 2 capsules x 4 times a day (200 mg x 4 times a day, only 800 mg нифуроксазида / days)
Children of 3-7 years: on 2 capsules x 3 times a day (200 mg x 3 times a day, only 600 mg нифуроксазида / days)
Capsules of 200 mg:
Adults and children are more senior than 7 years: on 1 capsules x 4 times a day (only 800 mg нифуроксазида / days)
Children of 3-7 years: on 1 capsule x 3 times a day (200 mg x 3 times a day, only 600 mg нифуроксазида / days)

Therapy nifuroksazidy should not continue more than 7 days.

Features of use:

At treatment of diarrhea along with therapy nifuroksazidy it is necessary to carry out rehydration therapy (peroral or intravenous) according to a condition of the patient and intensity of diarrhea.
During therapy use of alcohol is forbidden as it increases sensitivity of an organism to a nifuroksazid.
At emergence of symptoms of hypersensitivity (short wind, rash, an itch) it is necessary to stop administration of drug.

Influence on ability to manage vehicles and to work with mechanisms
Drug does not influence psychomotor activity, ability to manage transport and to work with mechanisms.

Side effects:

Nausea, vomiting, allergic reactions (rash, urticaria, Quincke's edema, acute anaphylaxis).

Interaction with other medicines:

There are no data on what нифуроксазид enters interaction with other medicines.

Contraindications:

• Hypersensitivity to derivatives of nitrofuran or other components of drug;
• Children's age up to 3 years (for this dosage form).
• Intolerance of fructose, syndrome of glyukozo-galaktozny malabsorption, insufficiency of invertase and isomaltase.
Use at pregnancy and a lactation
Use of the drug Enterofuril® at pregnancy is possible only in cases when the expected advantage of therapy for mother exceeds potential risk for a fruit.
Энтерофурил® it is not absorbed from digestive tract and does not get to system blood circulation, however use of drug in the period of a lactation is possible only according to strict indications, at the same time it is necessary to resolve an issue of the breastfeeding termination.

Overdose:

Drug is not absorbed from digestive tract and does not get to system blood circulation. Symptoms of overdose are unknown. In case of exceeding of a dose the gastric lavage and a symptomatic treatment is recommended.

Storage conditions:

At a temperature not above 30 °C. To store in the place, unavailable to children. Period of validity of 5 years. Not to use after a period of validity.

Issue conditions:

Without recipe

Packaging:

Capsules.
Dosage of 100 mg
On 10 capsules in the blister from a film of PVC and aluminum foil. On 3 blisters with the application instruction place in a cardboard pack.
Dosage of 200 mg
On 8 capsules in the blister from a film of PVC and aluminum foil. On 2 or 4 blisters with the application instruction place in a cardboard pack.