Baktroban ointment nasal

General characteristics. Structure:

Active ingredient: мупироцин calcium of 21.5 mg that corresponds to the maintenance of a mupirotsin of 20 mg

Excipients: paraffin white soft - 929.6 mg, софтизан 649 - 48.9 mg.

3 g - aluminum (1) with a tip plastic - packs cardboard.

Pharmacological properties:

Mupirotsin - an antibiotic of local action. Mupirotsin suppresses izoleytsil-transfer-RNK-sintetazu, breaking synthesis of protein in a bacterial cell. Owing to the specific mechanism of action and unique chemical structure, мупироцин does not find cross resistance with other antibiotics. At the correct use of a mupirotsin risk of emergence of resistant strains of microorganisms small. When using in the minimum inhibiting concentration мупироцин possesses bacteriostatic, and in higher concentration — bactericidal properties.

Antibacterial activity: in vitro is effective in Staphylococcus aureus relation (including Methicillinum - resistant strains), Staphylococcus epidermidis, Streptococcus spp. and also concerning gram-negative microorganisms: Haemophilis influenzae and Escherichia coli. Other gram-negative microorganisms are less sensitive, and strains of Pseudomonas aeruginosa of a rezistentna to action of a mupirotsin.

Efficiency concerning the listed microorganisms is confirmed clinically.

Pharmacokinetics. Mupirotsin after intranasal use gets to a system blood stream at use for newborn and premature children, without causing any undesirable effects testimonial of intolerance of drug. Absorption of a mupirotsin through mucous (less than 1% of the put dose are removed by kidneys in the form of moniyevy acid).

Indications to use:

— the local infections of a nasal cavity caused by microorganisms, sensitive to a mupirotsin, including Staphylococcus aureus carriage (including Methicillinum - resistant strains).

Route of administration and doses:

Ointment is applied by means of the applicator (a tuba of reusable use). After processing of a mucosal surface the nasal courses should be squeezed densely that provides hypodispersion of ointment on a mucous nasal cavity.

The course of treatment makes 3-5 days. It is not necessary to use drug more than 10 days without revaluation of a state. It is not necessary to mix with other medicines for intranasal use in order to avoid cultivation of ointment and, therefore, decrease in antibacterial activity or possible change of stability of intranasal ointment.

To put a small amount of ointment, volume approximately about a match head (about 30 mg of ointment), in each nasal course 2 for 5 days.

Features of use:

To avoid hit in eyes. At hit in eyes - to wash out a large amount of water before full removal of the remains of ointment.

Influence on ability to driving of motor transport and to control of mechanisms

The negative impact on these functions is not revealed.

Side effects:

In 12 clinical trials the frequency of undesirable reactions made less than 0.1%. Separate messages on development of undesirable reactions arrived (<1/10 000) during routine use of drug and the specified frequency is connected rather with the frequency of messages, than with a reaction development frequency.

Undesirable reactions on bodies and systems are listed below, with the indication of frequency of their emergence. Determination of frequency: very often (> 1/10), it is frequent (> 1/100, but <1/10), infrequently (> 1/1000, but <1/100), is rare (> 1/10 000, but <1/1000), is very rare (<1/10 000).

From immune system: very seldom - local reactions of hypersensitivity.

From respiratory tracts: infrequently - allergic reactions from mucous.

Interaction with other medicines:

It is noted.

Contraindications:

— the known hypersensitivity to any of drug components.

Drug BAKTROBAN® use ointment nasal at pregnancy and feeding by a breast.
Data on use of drug at pregnancy and in the period of a lactation are not available. Nevertheless, preclinical these studying of drug did not reveal a negative impact on the course of pregnancy or embryonic development.

Overdose:

So far messages on overdose by drug did not arrive.

Storage conditions:

Drug should be stored at a temperature not above 25 °C in the place, unavailable to children. A period of validity - 3 years. Not to accept drug after the expiry date specified on packaging.

Issue conditions:

According to the recipe

Packaging:

- ointment of nasal 2%: 3 g with a tip - P N012295/01, 09.07.07. Validity period рег. уд. it is not limited.

- ointment of nasal 2%: 3 g with a tip - P N012295/01, 09.07.07. Validity period рег. уд. it is not limited.