Supirotsin

General characteristics. Structure:

Active agent: мупироцин – 2 g.

Excipients: macrogoal 400 (polyethyleneglycol 400), macrogoal 4000 (polyethyleneglycol 4000).

Pharmacological properties:

Pharmacodynamics. Mupirotsin – the antibiotic produced by Pseudomonas fluorescens microorganism. Mupirotsin suppresses synthesis of protein of a bacterial cell by means of reversible binding with izoleytsit – acceptor RNA – sintetazy that prevents inclusion of isoleukin in proteinaceous chains under construction. When using in the minimum inhibiting concentration мупироцин possesses bacteriostatic, and in higher concentration – bactericidal action. Thanks to the specific mechanism of action and unique chemical structure, cross resistance with other antibiotics is absent.
At the correct use of a mupirotsin risk of emergence of rzistentny strains of microorganisms small.
Range of antibacterial activity of in vitro:
Gram - positive aerobes:
Staphylococcus aureus (including strains, resistant to Methicillinum and producing beta лактомазы),
Staphylococcus epidermidis,
Staphylococcus speciese,
Koagulazonegativnye Staphylococcus.

Gram – negative anaerobe bacterias:
Haemophilus influenzae,
Neisseria gonorrhoeae,
Neisseria meningitidi,
Branhamella catarrhalis,
Pasteurella multocida,
Proteus mirabilis,
Proteus vulgaris,
Enterobacter cloacae,
Entarobacter aerogenes,
Citrobacter freundii,
Bordetella pertussis.

Insensitive:
Corynebacterium species,
Enterobacteriaceae,
Gram-negative nefermentruyushchy sticks,
Micrococcus.

Pharmacokinetics. Mupirotsin practically does not get through the unimpaired integuments. In case of adsorption through the injured skin it is metabolized to microbiological inactive metabolite – moniyevy acid – and quickly removed by kidneys.

Indications to use:

Primary and secondary infectious damages of skin caused by microorganisms, sensitive to a mupirotsin, including:
primary infections of skin:
- impetigo,
- folliculitis,
- furunculosis (including furuncles of outside acoustical pass and auricle),
- ecthymas,
consecutive infections:
- the infected eczema,
- the infected injuries (grazes, stings of insects, wounds, burns).

Route of administration and doses:

A small amount of a mupirotsin is applied on the struck surface of skin. From above the bandage can be applied. After putting drug on skin it is necessary to wash up hands carefully.
To apply 2-3 times a day depending on weight of defeat. In the absence of clinical effect within 3 – 5 days it is recommended to revise the diagnosis and tactics of treatment.

Abnormal liver function
Does not demand correction.

Renal failure See the section "With Care".

Patients of advanced age: restrictions are not required. Also see the section "With Care".

Features of use:

Not to apply on mucous membranes and in the field of a drainage. It is necessary to avoid hit of ointment in eyes. At hit – carefully to wash out water before full removal of the remains of ointment.
In are rare cases of emergence of allergic reactions or considerable irritation of integuments at Supirotsin® ointment use, treatment should be stopped, to wash out an affected area water for removal of the remains of ointment and to appoint alternative antibacterial therapy.
As well as when using other antibacterial drugs, long purpose of Supirotsin® ointment can lead to the overgrowth of insensitive microorganisms.

Influence on ability to manage cars/mechanisms
Adverse influence on ability to manage cars/mechanisms was not observed.

Side effects:

Супироцин® ointment is well transferred. Burning, an itch in a drug site of application are very seldom observed. Less than in 1% of cases the erythema, a xeroderma can be observed, swelled, contact dermatitis. Skin allergic reactions (hypostasis in a site of application, rash) on мупироцин or a basis of ointment were observed seldom. At use of Supirotsin® ointment in isolated cases it was reported about generalized allergic reactions.

Interaction with other medicines:

It was not reported.
Supirotsin® ointment cannot be combined with other drugs for topical administration because of risk of its cultivation that it is shown by decrease in antibacterial activity and potential loss of stability.

Contraindications:

Hypersensitivity to any component of drug, children's age to 3kh years.

With care
The macrogoal – polyethyleneglycol – can be soaked up through a wound surface or through other damages of integuments and be removed by kidneys.
Ointments on the basis of a macrogoal cannot be applied on extensive surfaces at the states which are followed by the increased polyethyleneglycol absorption, and especially at a moderate and heavy renal failure.

Pregnancy and lactation
Now there are not enough data on use of a mupirotsin at pregnancy therefore use of drug is possible if the expected advantage exceeds possible risk of development of complications.
Removal of drug in breast milk is improbable, nevertheless, use of drug in the period of a lactation perhaps if the expected advantage exceeds possible risk of development of complications.

Overdose:

There are no data.

Storage conditions:

In the dry, protected from light place at a temperature not above 25 °C.
Not to freeze.
To store in the place, unavailable to children.

Issue conditions:

According to the recipe

Packaging:

Ointment for topical and external use of 2%.
On 15 g in the aluminum tubas from within varnished by latex, having a nozzle with the closed end with the cover having an edge for piercing.
One tuba together with the application instruction is located in a cardboard pack.