Baktroban

General characteristics. Structure:

Active ingredient: мупироцин 2.2 g

Excipients: macrogoal of 400 - 58.7 g, macrogoal of 3350 - 39.1.

15 g - aluminum (1) with a tip aluminum - packs cardboard.

Pharmacological properties:

Antibiotic of a broad spectrum of activity for external and topical administration. Mupirotsin is produced by Pseudomonas fluorescens microorganism.

Inhibits synthesis of protein in a bacterial cell by means of reversible binding with isoleucyl-TRNK-sintetazoy that prevents inclusion of an isoleucine in proteinaceous chains under construction.

At use in the minimum inhibiting concentration мупироцин possesses bacteriostatic, and in higher concentration - bactericidal action.

Thanks to the specific mechanism of action and unique chemical structure, cross resistance with other antibiotics is absent. At adequate use of a mupirotsin risk of emergence of resistant strains of microorganisms small.

In vitro Baktroban® is active concerning gram-positive aerobic microorganisms: Staphylococcus aureus (including strains, resistant to Methicillinum and the producing β-lactamelements), Staphylococcus epidermidis, other koagulazonegativny types of Staphylococcus, Streptococcus spp.; gram-negative anaerobic microorganisms: Haemophilus influenzae, Neisseria gonorrhoeae, Neisseria meningitidis, Branhamella catarrhalis, Pasteurella multocida, Proteus mirabilis, Proteus vulgaris, Enterobacter cloacae, Enterobacter aerogenes, Citrobacter freundii, Bordetella pertussis.

Are steady against drug: Corynebacterium spp., Enterobacteriaceae spp., gram-negative not fermentative sticks, Micrococcus spp.

Pharmacokinetics. Mupirotsin practically does not get through the unimpaired integuments.

In case of absorption through the injured skin мупироцин it is metabolized to microbiological inactive metabolite - moniyevy acid - and quickly brought out of an organism by kidneys.

Indications to use:

— treatment of primary infections of skin: impetigo, folliculitis, furunculosis (including furuncles of outside acoustical pass and auricle), ecthyma;

— treatment of consecutive infections of skin: the infected eczema infected an injury (grazes, stings of insects), insignificant (not demanding hospitalization) wounds and burns;

— prevention of the bacterial damages and their complications arising owing to small wounds, cuts.

Route of administration and doses:

Ointment apply outwardly 2-3 Small amount of ointment apply on an affected area of skin, the bandage from above can be applied. Duration of a course of treatment makes up to 10 days, depending on weight of defeat. In case of lack of effect after 5 days of treatment it is recommended to revaluate further tactics of treatment taking into account dynamics of clinical indicators.

At children: there are no restrictions at use of drug. Efficiency and safety of ointment was studied at patients of 2 months within fundamental clinical programs.

Correction of the mode of dosing is not required from patients with an abnormal liver function.

Correction of the mode of dosing is not required from elderly patients.

After putting drug on skin it is necessary to wash up hands carefully.

Features of use:

Not to apply ointment on mucous membranes and in the field of a drainage.

It is necessary to avoid hit of ointment in eyes. At hit - carefully to wash out water before full removal of the remains of ointment.

In rare instances emergence of allergic reactions or considerable irritation of integuments at Baktroban® ointment use, treatment it is necessary to stop, to wash out an affected area water for removal of the remains of ointment and to appoint alternative antibacterial therapy.

As well as at use of other antibacterial drugs, prolonged use of Baktroban® ointment can lead to the overgrowth of insensitive microorganisms.

Influence on ability to driving of motor transport and to control of mechanisms

Negative influence on ability to driving and work with mechanisms was not observed.

Side effects:

Very seldom: burning, an itch in a drug site of application.

Less than 1%: erythema, xeroderma, hypostasis, contact dermatitis.

Seldom: skin allergic reactions in a site of application - hypostasis, rash.

In isolated cases: generalized allergic reactions.

Baktroban® ointment is well transferred.

Interaction with other medicines:

Baktroban® ointment cannot be combined with other drugs for external use because of risk of its cultivation that it is shown by decrease in antibacterial activity and potential loss of stability.

Contraindications:

— hypersensitivity to drug components.

With care: the macrogoal - polyethyleneglycol - can be soaked up through a wound surface or through other damages of integuments and be removed by kidneys.

Ointments on the basis of a macrogoal cannot be applied on extensive surfaces at the states which are followed by the increased polyethyleneglycol absorption, especially at a moderate and heavy renal failure.

Use of the drug BAKTROBAN® at pregnancy and feeding by a breast

Now there are not enough data on use of the drug Baktroban® at pregnancy therefore use of drug is possible only in case the expected advantage of therapy exceeds possible risk for a fruit.

Removal of drug with breast milk is improbable, nevertheless, drug use perhaps if the expected advantage of therapy for mother exceeds possible risk for the baby.

Overdose:

There are no data.

Storage conditions:

Drug should be stored in the place, unavailable to children, at a temperature not above 25 °C. A period of validity - 2 years.

Issue conditions:

According to the recipe

Packaging:

• ointment of 2%: 15 g with a tip - P N014801/01, 15.12.08. Validity period рег. уд. it is not limited.