Bonderm

General characteristics. Structure:

Active agent: мупироцин 20 mg

Excipients: macrogoal of 400 — 587 mg; macrogoal of 3350 — 393 mg.

Pharmacological properties:

Pharmacodynamics. Mupirotsin — a bacteriostatic antibiotic of a broad spectrum of activity for topical administration. Suppresses synthesis of bacterial proteins by reversible and specific linkng with an isoleucinetransport RNK-sintetazoy. Influences on causative agents of skin infections: Staphylococcus aureus (including strains steady against Methicillinum), Staphylococcus epidermidis, Staphylococcus saprophyticus and Streptococcus pyogenes (including koagulazonegativny strains). Has no cross stability with chloramphenicol, erythromycin, fuzidovy acid, gentamycin, lincomycin, Methicillinum, Neomycinum, streptomycin, tetracycline.

Pharmacokinetics. Mupirotsin practically does not get through the unimpaired integuments. In case of absorption through the injured skin it is metabolized to microbiological inactive metabolite — moniyevy acid — and quickly brought out of an organism by kidneys.

Indications to use:

Primary and secondary infectious damages of skin caused by microorganisms, sensitive to a mupirotsin, including:
- primary infections of skin — a pyoderma (a streptoderma, a staphyloderma): impetigo, sycosis, folliculitis, furunculosis (including furuncles of outside acoustical pass and auricle), ecthymas;
- consecutive infections — the infected eczema, the infected atopic, contact and allergic dermatitis, the infected injuries (grazes, cuts, scratches, stings of insects), trophic ulcers, insignificant (not demanding hospitalization) wounds and burns;
- prevention of the bacterial damages and their complications arising owing to small wounds, cuts, decubituses.

Route of administration and doses:

Outwardly.
A small amount of Bonderm® ointment is applied on the struck surface of skin by 2–3 times a day. A course of treatment — up to 10 days, depending on weight of defeat. In the absence of clinical effect in 5 days of treatment, it is recommended to revise the diagnosis and further tactics of treatment taking into account dynamics of clinical indicators.
Бондерм® ointment can be applied with use of an aseptic bandage or to put under an occlusive bandage.
Children and patients of advanced age. Restrictions are not required.
Abnormal liver function. Correction is not required.
Renal failure. See. "With care".

Features of use:

The macrogoal which is a part of ointment for external use is absorbed from open wounds and the injured skin and brought out of an organism by kidneys therefore patients with a heavy chronic renal failure should use drug with care on extensive sites of skin.

To avoid hit in eyes and on mucous membranes. At hit of ointment in eyes and on mucous membranes it is recommended to wash out carefully them water before full removal of the remains of ointment.

In rare instances emergence of allergic reactions or considerable irritation of integuments at ointment use Bonderm treatment should be stopped, to wash out an affected area water for removal of the remains of ointment and to appoint alternative antibacterial therapy.

Influence on ability to drive the car or to perform the works demanding the increased speed of physical and mental reactions. Adverse influence on ability to manage vehicles and mechanisms was not observed.

Side effects:

Бондерм® ointment is well transferred. Burning, an itch and dryness in a drug site of application are very seldom observed. Skin allergic reactions (hypostasis in a site of application, rash) on мупироцин or a basis of ointment were observed seldom. At use of ointment in isolated cases it was reported about generalized allergic reactions.

Interaction with other medicines:

It is necessary to avoid simultaneous use with other drugs for external use as it can reduce antibacterial activity or stability of a mupirotsin in ointment.

Contraindications:

- hypersensitivity to any component of drug;
- children's age up to 3 years.

With care: a renal failure (see. "Special instructions").

Use at pregnancy and feeding by a breast
Now there are not enough data on use of a mupirotsin at pregnancy therefore use of drug is possible if the expected advantage exceeds possible risk of development of complications.

Removal of drug in breast milk is improbable, nevertheless, use of drug for nursing mothers perhaps if the expected advantage exceeds risk of development of complications.

Overdose:

Overdose cases are until now not registered.

Storage conditions:

Ointment for external use, 2%. On 15 g in aluminum tubas. The opening of a tuba is protected by a membrane. For closing of a tuba PE a lid with cutting and a pin is used. The tuba is placed in a cardboard pack.

Issue conditions:

According to the recipe

Packaging:

In the dry, protected from light place, at a temperature not above 25 °C.
To store in the place, unavailable to children.