Vibrotsil

General characteristics. Structure:

Acting substance: 1 ml of drops contains a dimetinden of a maleate of 0,25 mg, Phenylephrinum of 2,5 mg;

Excipients: citric acid monohydrate, phosphate dinatrium anhydride, sorbitol, a benzalkoniya chloride, lavender oil to the deterpenovena, the water purified.

Pharmacological properties:

Pharmacodynamics. Vibrotsil - the combined drug containing Phenylephrinum and диметинден.

Drug reduces allocations from a nose and promotes clarification of the nasal courses, without breaking at the same time physiological functions of a ciliary epithelium and mucous a nose.

Phenylephrinum belongs to sympathomimetic amines. It is applied as nasal decongestant with moderated vasoconstrictive by action, selectively stimulates alpha adrenoceptors of cavernous venous tissue of mucous membrane of a nose. Thus, quickly and for a long time eliminates a rhinedema and its adnexal bosoms.

Dimetinden is the antagonist histamine H1 receptors - has antiallergic effect. It is effective at use in low doses, it is well transferred.

Pharmacokinetics. Vibrotsil is applied locally therefore his activity does not correlate with concentration of active agents in a blood plasma.

At accidental peroral absorption bioavailability of Phenylephrinum decreased and made about 38%, an elimination half-life - about 2,5 hours.

System bioavailability of a dimetinden after intake in solution makes about 70%, an elimination half-life - about 6 hours.

Indications to use:

Symptomatic treatment of cold, congestion of a nose, acute and chronic rhinitises, seasonal (hay fever) and nonseasonal allergic rhinitis, acute and chronic sinusitis, vasculomotor rhinitises. Auxiliary therapy at acute average otitis.

Preparation for surgical intervention in a nose and elimination of a rhinedema and adnexal bosoms after surgical intervention.

Route of administration and doses:

Before administration of drug it is necessary to clean a nose carefully.

Children from 1 to 6 years
On 1 or 2 drops in each nasal course 3-4 times a day.

Adults and children of 6 years
On 3 or 4 drops in each nasal course 3-4 times a day.

The term of treatment should not exceed 7 days and depends on sharpness of a disease.

Features of use:

Vibrotsil it is not necessary to apply longer than 1 week. Prolonged or excessive use of drug can cause tachyphylaxes and effect of "ricochet" (medicamentous rhinitis).

As well as at zasosuvann of other vasoconstrictors, it is not necessary to exceed the recommended drug dose. Excessive застування drug, especially at children and elderly people, can cause manifestations of systemic action of drug.

It is necessary to appoint with care drug to patients with cardiovascular diseases, sick with a hypertension, diseases of a thyroid gland and the patient with closed-angle glaucoma.

Influence on ability to manage vehicles and mechanisms.
Does not influence.

Pregnancy. Drug is not appointed during pregnancy. Lactation. To the women nursing do not appoint drug.

Side effects:

Usually drug is well transferred.
Poorly expressed and tranzitorny local reactions from a mucous membrane of a nose are in some cases possible (burning sensation or dryness).

Interaction with other medicines:

Drug is contraindicated to the patients accepting MAO (MAO) inhibitors or accepting their last 14 days.

The patients accepting tricyclic antidepressants and anti-hypertensive drugs, such as β-adrenoblockers should appoint vasoconstrictors with care..........

Contraindications:

Hypersensitivity to any component of drug.

Drug, for the maintenance of Phenylephrinum, as well as other vasoconstrictors, is contraindicated at atrophic rhinitis, and also to the patients accepting MAO (MAO) inhibitors, or accepting their last 14 days.

Drug is contraindicated to children till 1 year.

Drug is not recommended to be used during pregnancy and feeding by a breast.

Overdose:

At accidental use of drug by small children serious side effects inside were not informed on any.

The majority of cases was symptomless, was very seldom informed on feeling of fatigue, a stomach ache, poorly expressed tachycardia, increase in the ABP, excitement, sleeplessness, pallor of integuments.

Treatment: use of absorbent carbon, is possible - purgatives at children of younger age (the gastric lavage is not required); to adults and children appoint plentiful drink for drink.

Storage conditions:

To store in the dry, protected from light and heating place at a temperature not above 30 °C.

Period of validity - 3 years.

Issue conditions:

Without recipe

Packaging:

On 15 ml of drops in a bottle with a cover dropper; on 1 bottle in a cardboard box.