Mezafeton - Darnitsa, solution for and 1% on 1 ml No. 10

General characteristics. Structure:

international and chemical names: Fenilefrin; 1 (meta-oxyphenyl) - 2 methylaminoethanols a hydrochloride;
main physical and chemical properties: Transparent colourless or slightly yellowish liquid; 
structure: 1 ml of solution contains hydrochloride Phenylephrinum - 10 mg (in terms of 100% substance); 
auxiliary substances: glycerin, water for an injection. 

Pharmacological properties:

Mezafeton-Darnitsa - synthetic adrenomimetichesky drug. Stimulates alpha adrenoceptors, does not influence heart beta adrenoceptors. Causes narrowing of arterioles and increase in arterial pressure (with possible reflex bradycardia). In comparison with noradrenaline and adrenaline increases arterial pressure less sharply, but works is longer. Cordial emission under the influence of Mezafetona-Darnits does not increase, and sometimes even decreases. Causes expansion of pupils (without influencing accommodation) and can lower intraocular pressure at otkrytouglovy glaucoma.

Pharmacokinetics. It is quickly soaked up from an injection site. The effect after hypodermic or intramuscular introduction comes in 10-15 min. and lasts for 1-2 hours. At intravenous administration the effect lasts about 20 minutes.

Indications to use:

The hypotension and collapse connected with decrease in a tone of vessels at intoxications, infectious diseases.
Appoint for the purpose of prevention of hypotension in the preoperative period and during operative measures.
Hypotension.

Route of administration and doses:

At an acute lowering of arterial pressure intravenously struyno in a dose 0,1 - 0,3 - 0,5 ml of 1% of solution in 40 ml 5 - 20 - 40% of solution of glucose or isotonic solution of sodium of chloride (enter slowly, if necessary introduction is repeated); intravenously kapelno (1 ml of 1% of solution in 250-500 ml of 5% of solution of glucose) Under skin and intramusculary 0,3-1 ml of 1% of solution appoint adult. The highest single dose under skin and intramusculary - 0,01 g, daily - 0,05 g, intravenously - one-time 0,005 g, daily 0,025 g

Features of use:

With care appoint at an ischemic disease and disturbances of a heart rhythm, at patients with aneurism, a hyperthyroidism, a diabetes mellitus, at elderly people.

Side effects:

Dizziness, fear, concern, heartbeat, disturbance of a cordial rhythm, pain in heart, hypertensia, disturbance of an urination, a headache, a hematencephalon, extravasates, pains in an injection site connected with irritant action.

Interaction with other medicines:

Mezafeton-Darnitsa increases risk of emergence of fibrillations of ventricles of heart at use with a halothane, cyclopropane and other galogensoderzhashchy anesthetics. The risk of arrhythmias increases also at simultaneous use of Mezafetona-Darnits with cardiac glycosides, quinidine, tricyclic antidepressants. Mezafeton-Darnitsa reduces efficiency of hypotensive drugs. Levels effects of alpha adrenoblockers. 

Contraindications:

Idiopathic hypertensia and all types of hypertensia, atherosclerosis, cardiosclerosis, tendency to a vasospasm, pregnancy, galotanovy or cyclopropane anesthesia, hypersensitivity to drug.

Overdose:

Symptoms: weakness, dizziness, blanching of the person, nausea, vomiting, fever, heartbeat, expansion of pupils, sight illegibility, concern, fear, headache, tremor, spasms, difficulty of breath, lump. Arterial pressure considerably increases at first, and then decreases. Fibrillations of ventricles of heart, a hematencephalon can take place.
Treatment: artificial respiration, oxygen. With a high arterial pressure - aminazine (2 ml of 2,5% of solution), a papaverine under skin (2 ml of 2% of solution), an Euphyllinum intravenously (5-10 ml of 2,4% of solution in 10-20 ml of 40% of solution of glucose).

Storage conditions:

To store in the place protected from light, at a temperature from 8 to 25 °C.

Period of validity - 3 years.

Issue conditions:

According to the recipe

Packaging:

On 10 ampoules in packaging.