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medicalmeds.eu Medicines Antihistaminic drugs for system use. Analerginum

Analerginum

Препарат Аналергин. Teva (Тева) Израиль


Producer: Teva (Tev) Israel

Code of automatic telephone exchange: R06AE07

Release form: Firm dosage forms. Tablets.

Indications to use: Rhinitis (cold). Allergic rhinitis (cold).


General characteristics. Structure:

International name: цетиризин; Main physical and chemical properties: white, round, film coated tablets which have dividing line on the one hand and a print of "CTZ 10" with another; Active ingredients: 10 mg of a tsetirizin dihydrochloride; Other substances: lactose, starch, magnesium stearate, opadr of Y-1-700.




Pharmacological properties:

Tsetirizin belongs to highly effective antihistamines which are noted by antiallergenic effect at use of therapeutic doses, and also the insignificant calming effect. It is one of the selection blockers of H1 receptors, and has insignificant impact on the others of receptors and therefore does not cause either anticholinergic, nor serotoninovy effects. Tsetirizin brakes an early phase of the allergic reaction mediated by a histamine and at the same time affects reduction of migration of cells of an inflammation and allocation of mediators during a late phase of allergic reaction.

Pharmacokinetics. Tsetirizin is quickly soaked up after oral administration. The maximum plasma level is reached for the period till one o'clock after use. The biological elimination half-life makes about 10 hours. at adult patients and 6 hours aged from 6 up to 12 years. The most part of a tsetirizin of N "contacts proteins of a blood plasma. Metabolism of a tsetirizin is carried out in a liver. About 2/3 accepted doses are allocated with urine. The imaginary general clearance of a tsetirizin decreases at insufficiency of function of kidneys. The elimination half-life lasts till 20 o'clock. At patients with insufficiency of kidneys which are treated by a hemodialysis. Only rather small part of a tsetirizin gets into liquid which is applied to dialysis. A biological elimination half-life stanovit12 hour at elderly patients. This phenomenon, obviously, p "is connected with depression of function of kidneys at elderly people.


Indications to use:

Drug is intended for therapy of seasonal and year-round allergic rhinitis, allergic the game "itching an itch and chronic idiopathic urtikarny rash at adult patients and children is more senior than 6 years.


Route of administration and doses:

Children of 6-12 years: 5 mg (1/2 tablets) two times a day or 10 mg (1 tablet) of times a day. Adult patients and children are more senior than 12 years: 10 mg (1 tablet) once a day. To patients with a renal failure, it is recommended to reduce a dose half.


Features of use:

Pregnancy and lactation. There is no sufficient clinical experiment on use of a tsetirizin during pregnancy. The experiments made on animals did not reveal teratogenic effect of drug. Use to a tsiterizin during pregnancy has to be reasonable. Tsiterizin gets into breast milk and therefore it should be applied to the patients nursing. Decrease in concentration is possible during driving of vehicles and control of cars. During clinical trials it was not proved that drug makes negative impact on the types of activity demanding the increased concentration as, for example, driving of vehicles or service of cars. Drug can cause drowsiness only in supersensitive patients. The given effect can be reduced to a minimum due to division of a daily dose into two receptions.


Side effects:

Side effects, such as, for example, drowsiness, headache, dizziness, concern, dryness in a mouth and disorder of functions of a digestive tract have preferential temporality and are observed quite seldom. In exceptional cases hypersensitivity symptoms (skin reactions, a Quincke's disease) can be observed.


Interaction with other medicines:

Interactions with other medicines were not described. At simultaneous use of drugs of diazepam and Cimetidinum the possibility of interaction was not confirmed. Strengthening of effect of drug at a concomitant use of alcohol was not proved (at blood alcohol level of 0,8 g/l). Despite it, the excessive use of alcoholic beverages is not recommended during treatment. Reduction of elimination of a tsetirizin from an organism in case of simultaneous use with theophylline in a dose of 400 mg/days was noted.


Contraindications:

Hypersensitivity to drug components.


Overdose:

Drowsiness can be an overdose symptom. It was observed after one-time reception 50 mg of a tsetirizin. In case of considerable overdose the stomach, therapy - symptomatic is recommended to wash out. The specific antidote is unknown.


Storage conditions:

To store in the unavailable to children, protected from light place, at a temperature of 10 °C - 25 °C in a cardboard box. A period of validity - 2 years.


Issue conditions:

Without recipe


Packaging:

Tablets on 10 mg in aluminum blisters No. 7, No. 10, No. 30, No. 50 in a cardboard box.



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