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medicalmeds.eu Medicines Antihistaminic drugs for system use. Аллеркапс

Аллеркапс

Препарат Аллеркапс. УП «Минскинтеркапс» Республика Беларусь


Producer: Minskinterkaps Unitary Enterprise Republic of Belarus

Code of automatic telephone exchange: R06AE07

Release form: Firm dosage forms. Capsules.

Indications to use: Allergic reactions (Allergy). Allergic conjunctivitis. Allergic rhinitis (cold). Small tortoiseshell. Chronic idiopathic small tortoiseshell. Dacryagogue. Sneezing.


General characteristics. Structure:

Active ingredient: 5 mg or 10 mg of a tsetirizin of dihydrochloride.

Excipients: magnesium stearate, lactose, potato starch.

Antiallergic drug.




Pharmacological properties:

Pharmacodynamics. Active agent of Allerkaps medicine - a tsetirizin dihydrochloride. Tsetirizin - a blocker of peripheral histamine H1 receptors, antihistaminic antiallergic means, Hydroxyzinum metabolite. In pharmacological active doses does not possess significant sedation. Brakes a gistaminoposredovanny early phase of allergic reaction, prevents various physiological and pathophysiological effects of a histamine, such as expansion and a hyperpermeability of capillaries (edematization, small tortoiseshells, reddening), stimulation of sensitive nerve terminations (an itch, pain) and reduction of unstriated muscles of a respiratory organs and digestive tract.

At a late stage of allergic reaction of Allerkaps inhibits allocation of a histamine and migration of eosinophils and other cells, weakening thus, late allergic reaction. Reduces an expression of molecules of adhesion, such as ICAM-1 and VCAM-1 which are markers of an allergic inflammation. Suppresses action of other mediators and inductors of secretion of a histamine, such as PAF (platelet activating factor) and substance P. Drug considerably lowers the hyperreactivity of a bronchial tree arising in response to release of a histamine at patients with bronchial asthma. These effects are not followed by the central action.

Pharmacokinetics. Tsetirizin is quickly soaked up from digestive tract, its absorption reaches 70%, substantially communicates transport proteins of a blood plasma. It does not get through a blood-brain barrier. The maximum concentration of a tsetirizin of dihydrochloride in a blood plasma (0,3 mkg/ml) is reached between the thirtieth and sixtieth minutes after its reception in a dose of 10 mg.

At adults the semi-life period in plasma makes about 10 hours, children have from 6 to 12 years - 6 hours and from 2 to 5 years - 5 hours. At a renal failure the general clearance of drug decreases. Tsetirizin is practically not metabolized in a liver. Two thirds of the accepted dose are excreted in not changed view with urine.


Indications to use:

Apply for the purpose of prevention and treatment of the allergic states caused by various allergens.

Аллеркапс it is shown for treatment at adults and children is more senior than six years:

- symptoms seasonal and year-round allergic rhinitises and allergic conjunctivitis, such as cold, itch, sneezing, rhinorrhea, dacryagogue, conjunctiva hyperemia;

- the symptoms of a small tortoiseshell, including chronic idiopathic small tortoiseshell and a Quincke's edema and other allergic dermatosis which are followed by an itch and rashes.


Route of administration and doses:

It is applied inside.

Adults and children are more senior than 6 years: daily dose of 10 mg.

Adults and children are more senior than 12 years: on 10 mg once a day, it is preferable for the night.

Children of 6-12 years: on 5 mg 1 or 2 times a day.

It is possible to begin with a dose 5 mg once a day if it yields satisfactory result. Elderly patients (on condition of normal function of kidneys) should not reduce a dose. Sick with a moderate or heavy renal failure it is recommended to reduce a dose twice.

Аллеркапс accept with a small amount of water. Duration of treatment is defined by the doctor.


Features of use:

It is not necessary to increase the therapeutic doses of Allerkaps recommended by the doctor. It is necessary to be careful to patients with a renal failure of moderate severity, to the patients who are on a hemodialysis and patients with disturbances of hepatic function. Tsetirizin is more slowly brought at patients of advanced age, than at more young people therefore it is necessary to increase an interval between medicine reception. It is recommended to control sometimes a gemogramma and activity of transaminases of a liver, especially in case of jaundice or formation of bruises and/or bleeding. If necessary it is necessary to interrupt treatment.

Consumption of alcoholic drinks during treatment by Allerkaps is categorically contraindicated!

During treatment it is necessary to be careful and not to increase the recommended therapeutic dose during the driving of motor transport and occupation other potentially dangerous types of activity demanding the increased concentration of attention and speed of psychomotor reactions.


Side effects:

Аллеркапс it is usually well transferred by patients. In rare instances reception can cause a headache, dizziness, drowsiness, feeling of fatigue, dryness in a mouth, excitement, gastrointestinal frustration. Weakness, nausea, vomiting, pain in a stomach, diarrhea, a lock and increase in appetite are sometimes noted.

During treatment by Allerkaps passing strengthening of activity of transaminases of a liver can be noted. Also hemolitic anemia or thrombocytopenia can be observed. Reactions of hypersensitivity in the form of skin reaction and vascular hypostasis are extremely rare.


Interaction with other medicines:

At co-administration of Allerkaps and theophylline (especially if doses of theophylline exceed 400 mg) increase in concentration in serum and relative overdose of a tsetirizin because of reduced clearance can be observed.

Clinically essential interactions with azithromycin, pseudo-Epinephrinum, ketokonazoly, erythromycin, diazepam and Cimetidinum are noted.

Myelotoxic medicines strengthen manifestations of a gematotoksichnost of a tsetirizin.

It is necessary to observe extra care at combined use of Allerkaps with hypnotic drugs and sedatives, alcohol.


Contraindications:

Аллеркапс it is contraindicated:

- to persons with anamnestic data on existence of reaction of hypersensitivity to any of components, and also to Hydroxyzinum;

- at pregnancy,

- when feeding by a breast since цетиризин gets into breast milk,

- at children's age up to 6 years.


Overdose:

The overdose of drug of Allerkaps was not observed.


Storage conditions:

Drug should be stored in the unavailable to children, dry, protected from light place at a temperature from 15 °C to 25 °C. A period of validity - 2 years.


Issue conditions:

Without recipe


Packaging:

On 10 capsules in blisters, on 2 blisters in cardboard packaging.



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