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medicalmeds.eu Medicines Anabolic means for system use. Potassium orotate

Potassium orotate

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Producer: JSC AVVA RUS Russia

Code of automatic telephone exchange: A05BA

Release form: Firm dosage forms. Tablets.

Indications to use: Liver diseases. Diseases of bilious ways. Chronic heart failure. Arrhythmia. Hypotrophy.


General characteristics. Structure:

Active agent: potassium оротат 500 mg

Excipients: lactose, potato starch, gelatin medical, stearic acid.




Pharmacological properties:

Pharmacodynamics. Orotovy acid is one of predecessors of the pirimidinovy nucleotides which are a part of nucleic acids which participate in synthesis of proteinaceous molecules in this connection, salts of orotovy acid are considered as substance of anabolic action and are applied at disturbances of protein metabolism, to their stimulation.
Usually apply potassium salt of orotovy acid (potassium оротат). Potassium оротат stimulates synthesis of nucleic acids, products of albumine in a liver (especially in the conditions of a long hypoxia), increases appetite, possesses diuretic, regenerating properties.

Pharmacokinetics. After intake in digestive tract 10% of the dose accepted inside are absorbed. In a liver turns into orotidin-5-phosphate. It is removed with urine (30% in the form of metabolites).


Indications to use:

As supportive application at the diseases of a liver and bilious ways (caused by acute and chronic intoxication, except for organic lesions of a liver and biliary tract):
- as a part of a combination therapy of chronic heart failure and disturbances of a heart rhythm;
- an alimentary and alimentary and infectious hypotrophy at children;
- chronic physical overstrain.


Route of administration and doses:

It is necessary to accept inside in 1 hour prior to food or in 4 hours after food. The adult on 250-500 mg 2-3 times a day. The course of treatment lasts on average 20-30 days. If necessary treatment can be repeated in 1 month. In exceptional cases it is possible to increase a dose of adults to 3 g a day. To children - on 10-20 mg/kg of body weight the day divided into 3-4 receptions (for example, if the body weight of the child of 25 kg, then the resolved dose - from 25 x 10 = 250 mg (1/2 tab.) to 25 x 20 = 500 mg (1 tab. the day divided into 3-4 receptions). Course of treatment of 3-5 weeks.
At preservation of symptoms of a disease consult with the doctor.


Features of use:

Does not cause drowsiness and reduction of speed of psychomotor reactions. During treatment observance of a diet is desirable.


Side effects:

Usually Potassium оротат it is well transferred. In some cases there can be allergic skin reactions which disappear after treatment interruption. Potassium оротат can also cause easy digestive disturbances (nausea, vomiting). At use in high doses against the background of a low-proteinaceous diet development of dystrophy of a liver is possible.
At emergence of side effects consult with the doctor.


Interaction with other medicines:

Potassium оротат reduces toxicity of cardiac glycosides a little; the effect increases at its combination with magnesium drugs. The knitting and enveloping means can reduce several absorption of potassium of an orotat in digestive tract.


Contraindications:

Hypersensitivity to any of drug components; acute and chronic organic lesion of a liver; ascites.


Overdose:

Data on overdose are absent.


Storage conditions:

In dry, protected from light and the place, unavailable to children, at a temperature not above 25 °C.


Issue conditions:

According to the recipe


Packaging:

Tablets on 500 mg.
On 10 tablets in planimetric bezjyacheykovy packaging from paper with a polymeric covering or from material of the combined film tseflen.
On 10 tablets in a blister strip packaging from a film of the polyvinyl chloride and printing aluminum foil varnished. On 10 tablets in a blister strip packaging from a film polyvinyl chloride and a foil of the aluminum printing varnished and flexible packaging in rolls on the basis of aluminum foil for medicines.
On 10 or 20 tablets in bank polymeric or a bottle polymeric. Each can or a bottle, or 1, 2 or 3 blister strip packagings together with the application instruction are placed in a pack from a cardboard. On 100, 150 planimetric bezjyacheykovy packagings or on 100, 150 blister strip packagings together with the same number of application instructions place in packages from a film polyethylene.



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