Ascorbic acid with glucose

General characteristics. Structure:

Active ingredients: 100 mg of ascorbic acid, 877 mg of glucose in 1 tablet.

Excipients: potato starch, talc, stearic acid.

Pharmacological properties:

Pharmacodynamics. Vitamin means, has metabolic effect, participates in regulation of oxidation-reduction processes, carbohydrate metabolism, coagulability of blood, an angenesis, in synthesis of steroid hormones; increases resistance of an organism to infections, reduces vascular permeability, reduces the need for B1, B2, A, E vitamins, folic acid, pantothenic acid.

Pharmacokinetics. Ascorbic acid is well soaked up preferential in duodenal and a jejunum. In 30 min. after introduction the content of ascorbic acid in blood considerably increases, begins intensive capture its fabrics due to its initial transformation into dehydroascorbic acid which has ability to get through cellular membranes without metabolic cost and to be recovered quickly in a cell. Intracellularly ascorbic acid is defined in three forms – ascorbic and dehydroascorbic acids and an askorbigen (the combined ascorbic acid).

Distribution between bodies uneven: there is a lot of it in hemadens, especially in adrenal glands, it is less – in a brain, kidneys, a liver, in cordial and skeletal muscles. Ascorbic acid is partially metabolized and emitted to 90% with kidneys in the form of oxalate, partially – in a free form. Glucose is easily soaked up, the main ways of metabolism is glycolysis and aerobic oxidation with formation of carbon dioxide and water with release of ATP and other makroergichesky connections.

Indications to use:

- Hypo - and avitaminosis of C; the increased need for ascorbic acid (the period of intensive growth, pregnancy, the lactation period, the raised exercise stresses, the reconvalescence period).

Route of administration and doses:

Inside. In terms of ascorbic acid:

- the adult with the preventive purpose – 50-100 mg/days, to children are 6-14 years on 50 mg of ascorbic acid a day, to children 14 years on 50-75 mg of ascorbic acid a day are more senior;

- the adult with the medical purpose – 50-100 mg of 3-5 times a day, to children since 6 years - 50-100 mg 2-3 times a day. Duration of therapy and a dose is established by the attending physician.

Features of use:

In connection with a promoting effect of ascorbic acid on synthesis of corticosteroid hormones it is necessary to monitor function of kidneys and arterial pressure. At prolonged use of high doses oppression of function of the insulyarny device of a pancreas therefore in the course of its treatment it is regularly necessary to control is possible.

At patients with the increased content of iron in an organism it is necessary to apply ascorbic acid in the minimum doses.

Purpose of ascorbic acid to patients with quickly proliferating and intensively metastasizing tumors can aggravate the course of process.

Ascorbic acid as a reducer can distort results of laboratory tests (content in blood of glucose, bilirubin, activity of "hepatic" transaminases and LDG).

Use during pregnancy and feeding by a breast. At pregnancy and in the period of a lactation apply only if the estimated advantage for mother exceeds risk for a fruit and the child. During pregnancy and a lactation ascorbic acid is accepted only on doctor's orders. Daily need for ascorbic acid for the II-III trimesters of pregnancy of 90-100 mg. It must be kept in mind that the fruit can adapt to high doses of ascorbic acid which is accepted by the pregnant woman, and then at the newborn development of a syndrome of "cancellation" is possible. Theoretically there is a danger to the child at use by the nursing mother of high doses of ascorbic acid (it is recommended not to exceed the nursing mother of daily need for ascorbic acid). The recommended daily need for ascorbic acid in the period of a lactation of 120 mg.

Influence on ability to manage motor transport and potentially dangerous mechanisms. Does not influence.

Side effects:

Allergic reactions, irritation of a mucous membrane of the digestive tract (DT) (nausea, vomiting, diarrhea, GIT spasm); oppression of function of the insulyarny device of a pancreas (hyperglycemia, glucosuria); at use in high doses – a hyperoxaluria and a nephrocalcinosis (oxalic).

Change of laboratory indicators: thrombocytosis, giperprombinemiya, erythropenia, neutrophylic leukocytosis, hypopotassemia.

Interaction with other medicines:

Ascorbic acid increases concentration in blood of benzylpenicillin and tetracyclines; in a dose of 1 g/days increases bioavailability of ethinylestradiol (including being a part of oral contraceptives).

Improves absorption in intestines of iron preparations, can increase removal of iron at simultaneous use with Deferoxaminum.

Reduces efficiency of heparin and indirect anticoagulants.

Acetylsalicylic acid, oral contraceptives, fresh juice and alkaline drink reduce absorption and assimilation.

Increases risk of development of a crystalluria at treatment by salicylates and streptocides of short action, slows down removal by kidneys of acids, increases removal of the medicines having alkali reaction (including alkaloids, reduces concentration in blood of oral contraceptives).

Increases the general clearance of ethanol which in turn reduces concentration of ascorbic acid in an organism.

In high doses increases removal of a meksiletin kidneys.

Barbiturates increase removal of ascorbic acid with urine.

Reduces therapeutic effect of antipsychotic medicines (neuroleptics) – derivatives of a fenotiazin, a canalicular reabsorption of amphetamine and tricyclic antidepressants.

Contraindications:

Hypersensitivity, children's age - up to 6 years, thrombophlebitises, tendency to fibrinferments.

With care. Diabetes mellitus, deficit glyukozo-6-fosfatdegidrogenazy; for use in high doses – hemochromatosis, sideroblastny anemia, a thalassemia, a hyperoxaluria, нефроуролитиаз.

Overdose:

Symptoms: at use more than 1 g – a headache, increase in excitability TsNS, sleeplessness, nausea, vomiting, diarrhea, hyperacid gastritis, an ultseration of a mucous membrane of a GIT, oppression of function of the insulyarny device of a pancreas (a hyperglycemia, a glucosuria), a hyperoxaluria, a nephrolithiasis (from oxalate calcium), damage of the glomerular device of kidneys, a moderate pollakiuria (at reception of a dose more than 600 mg/days). Decrease in permeability of capillaries (deterioration in a trophicity of fabrics, increase in the arterial pressure (AP), hypercoagulation, development of mikroangiopatiya is possible).

Storage conditions:

In the place protected from light and moisture, at a temperature not over 25 ºС. To store in the place, unavailable to children. A period of validity - 1 year. Not to use after the termination of a period of validity.

Issue conditions:

Without recipe

Packaging:

In a blister strip packaging No. 10, in packaging No. 10 x 2. In planimetric bezjyacheykovy packaging No. 10, in packaging No. 10 x 1.