Drotaverinum

General characteristics. Structure:

Active agent:  Drotaverinum a hydrochloride (in terms of 100% substance) – 40 mg.
Excipients: lactoses monohydrate (sugar milk) - 52 mg, starch potato, povidone (polyvinylpirrolidone low-molecular medical), magnesium stearate, talc.

Description: tablets  of color, yellow with a greenish shade, ploskotsilindrichesky with a facet.

Pharmacological properties:

Treats spasmolysants of myotropic action, derivative isoquinoline.  On chemical structure and pharmacological properties it is close to a papaverine, but possesses stronger and long action. Inhibits phosphodiesterase IV that leads to accumulation of intracellular adenosinemonophosphoric acid, and as a result to an inactivation of an easy chain of a kinase of a myosin therefore there is a relaxation of smooth muscles of internals. Irrespective of type of a vegetative innervation, Drotaverinum  affects unstriated muscles of digestive tract, bilious, urinogenital and vascular systems. In a myocardium and vessels the enzyme hydrolyzing tsAMF is phosphodiesterase III that explains lack of serious side effects from cardiovascular system (CCC) and not expressed therapeutic action concerning CCC.

Pharmacokinetics. At oral administration  absorption – high, the period of semi-absorption of-12 min. Bioavailability of-100%. It is evenly distributed in fabrics, gets into smooth muscle cells. Time of achievement of the maximum concentration (TCmax) of-2 h. Communication with proteins of plasma – 95-98%. It is generally removed by kidneys, to a lesser extent – with bile. Does not get through a blood-brain barrier (GEB). 

Indications to use:

Spasm of unstriated muscles of internals (renal colic, bilious colic, intestinal colic, dyskinesia of biliary tract and a gall bladder on hyperkinetic type, cholecystitis, a postcholecystectomy syndrome). 

As a part of a combination therapy: the pylorospasm, gastroduodenit, a peptic ulcer of a stomach and a 12-perstny gut, a spastic lock, a spastic colitis, a proctitis, tenesmus, a pyelitis. Tensor headache. 

During the carrying out some tool researches, cholecystography.

Route of administration and doses:

The adult appoint inside 40-80 mg (1-2 tablets) 2-3 times a day. To children 12 years drug are more senior appoint 40 mg (1 tablet) 1-3 times a day.  

Features of use:

At treatment of a peptic ulcer of a stomach and a 12-perstny gut accept in combination with other antiulcerous medicines.

During treatment it is necessary to abstain from control of vehicles and occupations potentially dangerous types of activity demanding the increased concentration of attention and speed of psychomotor reactions (within 1 hour after parenteral introduction).

Side effects:

Are possible – dizziness, a headache, sleeplessness, heartbeat, arterial hypotension, feeling of heat, perspiration, allergic dermatitis, nausea, a lock. 

Inform the attending physician on emergence in you of any undesirable or unpleasant reactions and feelings.

Interaction with other medicines:

At simultaneous use Drotaverinum can weaken protivoparkinsonichesky effect of a levodopa.

Contraindications:

Individual intolerance, the expressed hepatic, renal, cordial insufficiency, AV blockade of the II-III degree, the lactation period. Children's age up to 12 years. Patients with rare hereditary diseases, intolerance of a galactose, deficit of lactase or glyukozo-galaktozny malabsorption should not accept drug.

With care: 

Appoint drug to patients with the expressed atherosclerosis of coronary arteries, arterial hypotension, a prostate hyperplasia, glaucoma, during pregnancy.

Overdose:

There are no data on overdose concerning drug.

Storage conditions:

To store in the dry place protected from light at a temperature not above 25 °C.
To store in the place, unavailable to children.
Period of validity 3 years. After a period of validity not to use drug.
 

Issue conditions:

Without recipe

Packaging:

Tablets of 40 mg.

On 10 or 20 tablets in a blister strip packaging.

2 (on 10 tablets) blister strip packagings or 5 (on 10 tablets) blister strip packagings  with the application instruction place in a pack from a cardboard.

1200 (on 20 tablets) blister strip packagings with the equal  number  of application instructions place in a box from a cardboard (for hospitals).