Betadin vaginal suppositories

General characteristics. Structure:

Active ingredient: 200 mg povidone-iodine (there correspond 18 - 24 mg of active iodine) in each vaginal suppository. Excipients: macrogoal of 1000 2800 mg.

Description: Torpedo-shaped homogeneous suppositories of dark brown color.

Pharmacological properties:

Pharmacodynamics. Renders antiseptic, disinfecting, antifungal and anti-protozoan action. Blocks amino groups of cellular proteins. Possesses a wide range of antimicrobic action. It is active concerning bacteria (including colibacillus, golden staphylococcus), mushrooms, viruses, the elementary. Being released from a complex with polyvinylpirrolidone at contact with skin and mucous, iodine forms iodamines with proteins of a cell of bacteria, coagulates them and causes death of microorganisms. Has bystry bactericidal effect on gram-positive and gram-negative bacteria (except for M.tuberculosis).

Pharmacokinetics. At topical administration there is almost no iodine reabsorption from a mucous membrane.

Indications to use:

Acute or chronic vaginitis (the mixed, nonspecific infection), the bacterial vaginosis (caused by Gardnerella vaginalis), candidiasis, Trichomonas vaginalis infection. Vagina infections after therapy by antibiotics or steroid drugs. Prevention before surgical or diagnostic interventions in a vagina.

Route of administration and doses:

For introduction to a vagina. It is recommended to moisten suppository with water and to enter it deeply into a vagina in the evening before going to bed.
On 1 suppository to enter deeply into a vagina: at an acute vaginitis 1-2 times a day within 7 days, at a chronic and subacute vaginitis - 1 time a day before going to bed within 14 days (it is possible longer).
It is recommended to use also throughout a course of treatment hygienic laying. It is not necessary to stop use of suppositories during periods.

Features of use:

Due to the oxidizing properties its traces can result povidone-iodine in false positive results of some types of researches for detection of the occult blood in Calais, and also blood or glucose in urine.
During use povidone-iodine can decrease iodine absorption by a thyroid gland that can affect results of some diagnostic testings (for example, stsintigrafiya of a thyroid gland, definition of the proteinaceous and connected iodine, measurements using a radioiodine), and also can interact with the iodine drugs used for treatment of diseases of a thyroid gland. For obtaining undistorted results of a stsintigrafiya of a thyroid gland after long therapy povidone-iodine is recommended to sustain rather long span without this drug.
At dysfunction of a thyroid gland, drug can be used only according to instructions of the doctor. If during a course of treatment there are hyperthyroidism symptoms, it is necessary to check function of a thyroid gland. It is necessary to carry out control of function of a thyroid gland at newborns and babies raised by breast milk whose mothers applied Betadin.
It is necessary to be careful at regular use of drug for patients with earlier diagnosed renal failure. It is necessary to avoid regular use of vaginal suppositories Betadin at the patients receiving lithium drugs.
Use povidone-iodine is authorized since the neonatality period, but taking into account a release form - vaginal suppositories, drug is not recommended to be used up to 8 years and to be careful at introduction to virgins.
Coloring on skin and fabrics easily washes off. After contact with drug it is necessary to avoid its hit in eyes.
Suppositories possess spermicidal action in this connection their use for the persons planning pregnancy is not recommended.
During use of suppositories it is possible to recommend Use of hygienic laying.

Influence on ability to driving of motor transport and to control of mechanisms.
The correct use of drug does not influence ability to driving of motor transport and control of mechanisms.

Side effects:

Hypersensitivity reactions to drug, a hyperemia, an itch.
In rare instances it can cause hypersensitivity reactions, for example, contact dermatitis with formation of psoriazopodobny red small violent elements. At emergence of such phenomena use of drug should be stopped.
Prolonged use can lead povidone-iodine to absorption of significant amounts of iodine. Development of the hyperthyroidism caused by iodine is in certain cases described, it is preferential at patients with earlier being available disease of a thyroid gland.

Interaction with other medicines:

It is incompatible with other disinfecting and antiseptic agents which are especially containing alkalis, enzymes and mercury.
Combined use povidone of iodine and peroxide of hydrogen, and also the fermental drugs containing silver and таулоридин for processing of wounds, and also antiseptic drugs, leads to mutual decrease in efficiency.
In the presence of blood bactericidal action can decrease, however at increase in concentration of solution, bactericidal activity can be increased.

Contraindications:

Hypersensitivity to iodine and other components of drug; dysfunction of a thyroid gland (the nodal colloid craw, a local craw also tiroidit Hashimoto, a hyperthyroidism) (see the section "Special Instructions"); adenoma of a thyroid gland; herpetiform dermatitis of Dyuringa; simultaneous use of a radioiodine; children's age up to 8 years (see the section "Special Instructions").

With care: pregnancy and period of feeding by a breast.

Pregnancy and period of feeding by a breast
Betadin's use is not recommended from 3rd month of pregnancy and during a lactation. In need of these cases treatment is possible under individual medical control.

Overdose:

The following symptoms are characteristic of acute iodic intoxication: metal taste in a mouth, the increased salivation, a burning sensation or mouth or drink pain; irritation an eye also swelled; skin reactions; gastrointestinal frustration and diarrhea; renal failure and anury; circulatory unefficiency; throat hypostasis with secondary asphyxia, a fluid lungs, a metabolic acidosis, a hypernatremia.
Treatment: it is necessary to carry out a symptomatic and maintenance therapy with special attention to electrolytic balance, function of kidneys and a thyroid gland.

Storage conditions:

Period of validity of 5 years. Not to use after the expiry date specified on packaging. To store in the dry place at a temperature from 5 to 15 °C. To store in the place, unavailable to children.

Issue conditions:

Without recipe

Packaging:

Suppositories vaginal 200 mg. On 7 vaginal suppositories in the blister from film PVH/PE. On 1 or 2 blisters in a cardboard pack together with the application instruction.