Clonidine - Darnitsa, the tab. on 0.00015 g No. 50

General characteristics. Structure:

International and chemical name: Clonidinum; 2-(2,6-dikhlorfenilamino) - 2 imidazolines a hydrochloride;
main physical and chemical properties: tablets of white color;
structure: 1 tablet contains clonidine - 0,00015 g;
excipients: sugar milk, magnesium stearate, potato starch

Pharmacological properties:

Pharmacodynamics. Clonidine - an antihypertensive of the central action, the selection agonist postsynaptic alpha 2 - adrenoceptors of adrenergic neurons. Slows down processes of excitement in the center of a hemodynamics in a myelencephalon. Causes decrease in a tone of sympathetic department of nervous control of a vascular tone. Does not influence synthesis of catecholamines, but reduces noradrenaline exit from a nervous bombway, at the expense of feedback at stimulation alpha 2 - adrenoceptors. Owing to such action the general peripheric vascular resistance goes down, the heart rate and volume of cordial emission decreases and there occurs lowering of arterial pressure. Except the central action clonidine can work as an agonist peripheral postsynaptic alfa-1 adrenoceptors of vessels that in some cases uses of drug is shown by slight increase of arterial pressure of treatment in the beginning. Prolonged use of clonidine leads to reduction of a hypertrophy of a left ventricle and improvement of function of heart. Drug increases renal and reduces a cerebral blood stream a little. Lowers intraocular pressure, has sedative and analgesic action, reduces manifestations of opiate and alcoholic abstinence, feeling of unreasonable fear.

Pharmacokinetics. After intake drug is quickly and completely soaked up in a digestive tract. Bioavailability of drug approaches 100%. The maximum concentration in a blood plasma is reached in 1-2 hours. The hypotensive effect develops in 30-60 minutes after reception and remains for 8-12 hours. Clonidine has high lipophilicity and is widely distributed in fabrics, including TsNS. About 50% of the clonidine circulating in blood are metabolized in a liver with formation of inactive connections; it is removed with urine (40-60%) and with a stake (10%). The elimination half-life (T1/2) fluctuates over a wide range, averaging 12 hours (6-24 hours). Elimination of clonidine is slowed down at patients with the expressed renal failure. In comparison with men, at women more long period полувыведенимя is noted.

Indications to use:

All stages and clinical forms of arterial hypertension, for stopping of hypertensive crises; arterial гипертензйя in an early puerperal period. In ophthalmologic practice - for conservative treatment of primary open angle glaucoma. For elimination of an abstinence syndrome at drug addiction, simplification of disaccustoming when smoking, diagnosis of a pheochromocytoma and deficit of STG.

Route of administration and doses:

 As an antihypertensive inside appoint in an initial dose 0,075 mg 2-3 times a day. If the hypotensive effect insufficient, a single dose is increased by each 1-2 days on 0,0375 mg (1/4 tablets) to 0,15-0,3 mg on reception 3 times a day. At insufficient efficiency of drug in high doses treatment is supplemented with saluretics and others by gipotenzivnm means. At displays of atherosclerosis of brain vessels drug appoint 0,0375 mg in an initial dose. The daily dose usually makes 0,3-0,45 mg, sometimes - 1,2-1,5mg.
At narcotic abstinence Klofelin-Darnitsa appoint inside in the conditions of a hospital 0,15-0,3 mg 3 times a day with an interval of 6-8 hours for 5-7 days. In case of development of side effects the single dose is gradually reduced for 2-3 days, and then, if necessary drug is cancelled.

Features of use:

At treatment of Klofelinom-Darnitsa it is necessary to control arterial pressure regularly. It is necessary to consider that drug reduces mental and physical reactions at different types of operational activity. At administration of drug (especially in the beginning treatments), the control of motor transport is forbidden. Sharp drug withdrawal can lead to development of hypertensive crisis (withdrawal) therefore before its cancellation for 7-10 days it is necessary to reduce a dose gradually. At development of a withdrawal at once are returned to administration of drug and further cancel it gradually, replacing with other antihypertensives. For prevention of a withdrawal it is not necessary to appoint drug the patient who does not have conditions for his regular reception. 

Use of drug at pregnancy and in the period of a lactation perhaps in cases when the expected advantage exceeds a potential negative impact on a fruit or the child.

Side effects:

Feeling of dryness in a mouth, a lock. In the first days sedative action, a slight faint, increased fatigue, drowsiness, physical weakness is noted. Increase in a dose is higher than therapeutic can cause bradycardia, a collapse, a loss of consciousness.

Interaction with other medicines:

Klofelin-Darnits's appointment together with antidepressants, nifedipine and neuroleptics leads to decrease in its hypotensive action; neuroleptics strengthen sedation of Klofelin-Darnits. Klofelin-Darnitsa increases effect of anesthetics, and in combination with digoxin can strengthen an atrioventricular block. Blockers of adrenoceptors are antagonists of hypotensive action of Klofelin-Darnits, vazodilatator strengthen it.

In order to avoid strengthening of side effects Klofelin-Darnitsa it is not necessary to apply together with metildopy. At treatment of Klofelinom-Darnitsa alcohol intake is forbidden.

Contraindications:

Kardiogenny shock, arterial hypotension, endocardiac blockade, the expressed atherosclerosis of vessels of a brain, bradycardia, atrioventricular block of the II-III degree obliterating diseases of peripheral vessels, a condition of the expressed depression, pregnancy, especially in the first trimester.

Overdose:

Increase in doses of drug or use not to destination can cause a collapse, a loss of consciousness. Osnovnmi the principles of treatment of acute poisonings of Klofelinom-Darnitsa is the complex detoxication of an organism including accelerated its removal from an organism, and correction of disturbances from cardiovascular system (bradycardia, an atrioventricular block, hypotension).

Storage conditions:

To store in dry, protected from light and the place, unavailable to children. A period of validity - 4 years.

Issue conditions:

According to the recipe

Packaging:

On 10 tablets in blister strip packagings.