Ницерголин-Ферейн®

General characteristics. Structure:

Active ingredient: 0,004 g of a nitsergolin.

Excipients: tartaric acid, sugar milk.

Pharmacological properties:

Pharmacodynamics. Synthetic derivative ergot alkaloids with the attached bromzameshchenny rest of niacin. The Ergolinovy rest has alpha and adrenoceptor blocking effect, causes a vazodilatation and improves microcirculation. The contained rest of niacin has direct myotropic spasmolytic effect on a muscular coat of rezitentny vessels, increases their permeability for glucose (leveling opposite effect of an ergolinovy ring).

The most brightly this action is shown concerning vessels of a brain and extremities, improves a brain, pulmonary and renal blood stream. Reduces the vascular resistance of the central vessels, raises an arterial blood stream, increases delivery of oxygen and glucose. Improves blood supply in extremities, especially at a circulatory unefficiency owing to functional arteriopatiya. In therapeutic doses does not influence the ABP (at patients with arterial hypertension), can cause gradual moderate pressure decrease.

Pharmacokinetics. It is well soaked up in a GIT. Bioavailability makes about 60%. Cmax in blood is defined by 2-4 h. Is exposed to biotransformation in a liver with formation of inactive metabolites. It is excreted, generally with excrements.

Indications to use:

Acute and chronic disorders of cerebral circulation (cerebral atherosclerosis, cerebral thrombosis and embolism, tranzitorny cerebral ischemia, posttraumatic encephalopathy, psychoorganic syndrome); dizziness, migraine; vascular disorders of the peripheral blood circulatory system (organic and functional, acute and chronic arteriopatiya of extremities, obliterating endarteritis, Raynaud's disease, diabetic angiopatiya).

Dystrophic diseases of a cornea, diabetic retinopathy, ischemic neuropathy of an optic nerve.

As supportive application - at arterial hypertension, hypertensive crisis (parenteral administration).

Route of administration and doses:

The way of introduction, dose and course of treatment depend on individual indicators of a hemodynamics of the patient.

Nitsergolin appoint intramusculary, intravenously and vnutriarterialno, previously having dissolved 0,9% in the enclosed chloride sodium solution.

Intramusculary enter 2-4 mg 2 times a day, intravenously kapelno on 4-8 mg on a dose into 100 ml of normal saline solution of sodium chloride (if necessary administration of drug can be repeated several times a day), vnutriarterialno - on 4 mg on a dose into 10 ml of normal saline solution of sodium of chloride within 2 min.

Features of use:

After parenteral administration of drug for prevention of orthostatic effect it is recommended to be in horizontal position within 10-15 min.

If pulse rate at rest makes less than 50 blows in min., administration of drug is possible only at careful medical control.

Side effects:

Dyspepsia: nausea, vomiting, diarrhea, abdominal pains; dermahemia of the person and upper half of a trunk, caumesthesia, drowsiness, sleeplessness, arterial hypotonia, headache, dizziness, stenocardia, ergotism symptoms: cold snap of extremities, pain and disturbance of functions of extremities; skin itch, allergic reactions.

Interaction with other medicines:

Strengthens action of antihypertensives, tranquilizers and neuroleptics.

Sympathomimetics when sharing can cause an idiosyncrasy.

Antacids and холестирамин slow down absorption.

Contraindications:

- hypersensitivity;
- the expressed atherosclerosis of peripheral vessels;
- organic lesions of heart;
- angina of exertion;
- myocardial infarction;
- arterial hypotonia;
- pregnancy;
- lactation period.

Storage conditions:

List B. In the place unavailable to children protected from light, at a temperature not above 25 °C. A set period of validity - 3 years. It is impossible to use drug after the expiry date specified on packaging.

Issue conditions:

According to the recipe

Packaging:

On 0,004 g of active ingredient in ampoules from neutral glass. 5 ampoules with drug place in a blister strip packaging from a film polyvinyl chloride; from a film of the polyvinyl chloride and printing aluminum foil varnished or a packing material.

5 ml of solution of sodium of chloride of isotonic 0,9% for injections in ampoules from neutral glass.

Set: one blister strip packaging with 5 ampoules of drug and one blister strip packaging with 5 ampoules of solution of sodium of chloride of isotonic 0,9% for injections, the application instruction - place in a pack from a cardboard.