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medicalmeds.eu Medicines Antiviral and immunoexcitants. Tiloron

Tiloron

Препарат Тилорон. ОАО "Мосхимфармпрепараты" им. Н. А. Семашко" Россия


Producer: JSC Moskhimfarmpreparaty of N. A. Semashko" Russia

Code of automatic telephone exchange: J05AX

Release form: Firm dosage forms. Capsules.

Indications to use: Viral hepatitis And (Infectious disease). Viral hepatitis of B. Viral hepatitis of C. Herpes infection (Herpes). Cytomegaloviral infection. Multiple sclerosis. Leukoencephalitis. Respiratory clamidiosis. Urogenital clamidiosis. Prevention of flu. SARS.


General characteristics. Structure:

Active ingredient: тилорон (in terms of 100% substance) - 125 mg; 

Excipients: cellulose microcrystallic (Vivapur type 102), коповидон (Plasdon S-630), silicon dioxide colloid (Aerosil), calcium stearate, capsules firm gelatinous No. 1 (titanium E-171 dioxide, gelatin, dye sunset yellow E-110).

Description: Capsules gelatinous firm No. 1 of orange color. Contents of capsules - the granulate containing granules and powder of orange color impregnations from light orange till dark orange color are allowed.




Pharmacological properties:

Pharmacodynamics. The low-molecular synthetic inductor of interferon stimulating education in an organism of interferon an alpha, a beta and scale. The main producers of interferon in response to introduction of a tiloron are intestines epithelium cells, hepatocytes, T lymphocytes, neutrophils and granulocytes. After intake at most of products of interferon intestines - a liver - blood are defined by 4-24 h in the sequence. In leukocytes of the person induces interferon synthesis.  Stimulates stem cells of marrow, depending on a dose strengthens antibodyformation, reduces immunosuppression degree, recovers ratios of T-suppressors and T-helperov. The mechanism of antiviral action is connected with inhibition of broadcast of virus-specific proteins in the infected cells therefore the reproduction of viruses is suppressed. It is effective concerning causative agents of a viral hepatitis, gerpesvirus (including cytomegaloviruses).

Pharmacokinetics. After intake it is quickly soaked up from digestive tract. Bioavailability - 60%. About 80% of drug contact proteins of plasma. Drug practically in not changed view with excrements (70%) and with urine (9%) is removed. T1/2 - 48 h. Drug is not exposed to metabolism and does not kumulirut.


Indications to use:

At adults: a viral hepatitis And, In, With, a herpes and Cytomegaloviral infection, complex therapy: infectious and allergic and viral encephalomyelitis (multiple sclerosis, a leukoencephalitis, uveoentsefalit), chlamydial infections of an urogenital and respiratory path; prevention of flu, etc. Acute respiratory viral infection.


Route of administration and doses:

Inside, after food, with the preventive purpose - on 125 mg once a week during 4-6 weeks, with medical - on 125-250 mg/days within 1-2 days, then on 125 mg in 48 h. Course of treatment: flu and other acute respiratory viral infections at adults - 1 week; hepatitis A - 2-3 weeks; hepatitis B - 3-4 weeks; herpes, Cytomegaloviral and chlamydial infections and their combinations - 4 weeks. A chronic viral hepatitis In and With, hepatitises-mikst - on 250 mg 2 times a week, a course of treatment - 2-4 weeks. Secondary immunodeficiences and disturbances of the interferon status - on 125 mg 2 times a week. A course of treatment - 2-4 weeks. Multiple sclerosis - on 125 mg in 48 h (only 10 capsules).



Side effects:

Allergic reactions. Dispeptic phenomena, short-term fever.


Interaction with other medicines:

Let's combine with antibiotics, medicines for treatment of viral and bacterial diseases.


Contraindications:

Hypersensitivity, pregnancy, the lactation period, children's age (up to 7 years).



Storage conditions:

List B. In the dry, protected from light place at a temperature not above 25 °C. To store in the place, unavailable to children.


Issue conditions:

Without recipe


Packaging:

Capsules of 125 mg. 6 or 10 capsules in a blister strip packaging from a film of PVC and a foil. 1 blister strip packaging together with the application instruction in a pack from a cardboard.



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