Spazgan

Spazgan is the combined drug relating to group of spasmolytic and analgetic means. Drug is produced in the form of tablets and solution for intravenous injections.

Tablets: flat, round a white or yellowish shade with a logo on the one hand and risky with another.

Solution for injections: colourless, transparent or with a subtle yellowish shade.

Spazgan's list:

1 tablet of medicine contains 500 mg of metamizole sodium, 5 mg of a pitofenon of a hydrochloride and 100 mkg a bromide fenpiveriniya.

1 ampoule of solution for injections contains 1 g of metamizole sodium, 400 mkg of a pitofenon of a hydrochloride and 4 mkg a bromide fenpiveriniya.

The ternary list of Spazgan leads to strengthening of their pharmacological action.

Pharmacological action Spazgan

In the instruction to Spazgan mutual strengthening of properties of drug thanks to the combined combination of the components having analgetic and spasmolytic properties is noted. Metamizole sodium has febrifugal and analgeziruyushchy effect, and the hydrochloride and a fenpiveriniya which are Spazgan's part of a pitofenon bromide relax smooth muscles, having on it complex papaverinopodobny effect.

Indications

Spazgan's use is recommended at the weak or moderately expressed pain syndrome, spasms of smooth muscles of intestines, bladder and an ureter, renal, gastric, bilious gripes. Responses to Spazgan confirm efficiency of administration of drug at dyskinesia of biliary tract, chronic colitis, a postcholecystectomy syndrome, diseases of bodies of a small pelvis. In some cases medicine is used at short-term therapeutic treatment of a mialgiya, arthralgia, neuralgia, an ischialgia.

Also indications to Spazgan do not exclude use of drug as supportive application at removal of a pain syndrome after the diagnostic procedures and surgical interventions.

Contraindications to use

Drug is not recommended to be used with hypersensitivity to the components which are Spazgan's part (including, to pyrazyl ketone derivatives), the expressed renal and liver failure, heavy stenocardia, a tachyarrhythmia, a hyperplasia of a prostate, intestinal impassability. Spazgan's use at pregnancy (especially, in I and III trimesters), breastfeeding is forbidden. During pregnancy administration of drug is justified only if indications to Spazgan exceed risk of emergence in a fruit of malformations.

At intravenous administration Spazgan is contraindicated at infantile age (up to 3 months), in tablets - at children's age up to 5 years.

Side effects

According to the instruction to Spazgan, drug has the following side effects:

• From an urinary system: an oliguria, a renal failure, a proteinuria, an anury, coloring of urine in red color;
• From cardiovascular system and bodies of a hemopoiesis: lowering of arterial pressure, tachycardia, disturbance of a cordial rhythm, thrombocytopenia, agranulocytosis, leukopenia;
• From the central nervous system: headache, dizziness.

In responses to Spazgan also possible allergic reactions are noted: a Quincke's disease, a small tortoiseshell, in rare instances - Stephens-Johnson's syndrome (a malignant exudative erythema), a bronkhospastichesky syndrome, an epidermal necrolysis, an acute anaphylaxis.

At overdose there can be hypotonia symptoms, vomiting, drowsiness, nausea, spasms, disturbance of functions of kidneys and a liver. As treatment the gastric lavage, reception of absorbent carbon, other symptomatic therapy are applied.

Interaction with other medicines

Despite the available indications to Spazgan, solution for injections is not recommended to be combined with other medicines. At combined use with phenyl propyl ketones, tricyclic antidepressants, fenotiazina, quinidine and amantadiny, according to reviews to Spazgan, strengthening of m-holinoblokiruyushchego of action is observed. The concomitant use of drug with Chlorpromazinum can lead to emergence of the expressed hyperthermia, and Allopyrinolum and oral contraceptives increase toxicity of medicine. According to the instruction, Spazgan is not compatible to penicillin, colloid blood substitutes and X-ray contrast medicines.

Special instructions

During Spazgan's use it is not recommended to accept ethanol, alcoholic beverages, to manage vehicles and to be engaged in the types of activity demanding speed of mental and physical reaction.

In responses to Spazgan it is warned about need of control in the course of treatment of the maintenance of leukocytes in peripheral blood. At the slightest suspicion of thrombocytopenia and an agranulocytosis, it is recommended to stop administration of drug at once! Treatment by Spazgan for decrease in acute abdominal pains - before clarification of their reason is inadmissible.

Use and its dosage

In the instruction to Spazgan it is said that the dosage of medicine depends on age and features of a disease of the patient. Nevertheless, the recommended dosage in the presence of indications to Spazgan makes 6 tablets a day (for adults and children 15 years), 3 tablets a day (for children aged from 13-15 years are more senior) and one tablet a day for children of 6-12 years. The daily dose of Spazgan should not exceed 6 tablets or 10 ml.

Intravenous injections of drug need to be done slowly, under strict control of heart rate, breath and arterial pressure. At the same time solution for injections has to be room temperature.

Spazgan's tablets, according to reviews, use inside, after food, washing down with enough water.

The instruction to Spazgan is not the recommendation to the drug use. Before use consult with the doctor!