Livolin Forte

General characteristics. Structure:

Acting substances:

Essential phospholipids of 300 mg
Thiamin mononitrate of 10 mg
Riboflavinum of 6 mg
Pyridoxine hydrochloride of 10 mg
Cyanocobalamine of 10 mkg
Niacinamide of 30 mg
Tocopherol acetate of 10 mg
Other ingredients: oil soy, the vegetable oil hydrogenated wax white, gelatin, the water purified titanium dioxide, ferrous oxide red (Е 172), ferrous oxide black, ferrous oxide yellow.

Pharmacological properties:

Pharmacodynamics. Active active ingredient of Livolin Forte is the lecithin of 35% containing phospholipids which represent high cleaning fraction of phosphatidylsincaline. The defining component of this fraction is дилинолеоилфосфатидилхолин. The specified phospholipids on the chemical structure are similar to endogenous membrane phospholipids which surpass them in functional properties at the expense of the high content of polyunsaturated fatty acids, especially linolic acid. Phospholipids are the basic structural elements of covers of cells and cellular organellas. They take part in differentiation, division and cell regeneration. Functional value of phospholipids is based on their amfifilny properties allowing to regulate permeability of a cellular cover. Phospholipids improve function of membranes, in particular ion exchange, intracellular breath, biological oxidation, influence binding of enzymes of internal respiration in mitochondrions, and also on oxidizing phosphorylation in energy balance of cells. In physiological conditions synthesis of phospholipids covers normal needs of hepatocytes which contain enough phospholipids. It is known that structures of cellular covers and fermental systems at diseases of a liver are exposed to pathological changes. Biosynthesis of phospholipids is broken, and their shortcoming leads to dysfunction of a cellular cover. These processes are especially expressed in mitochondrions which approximately for 30% consist of phospholipids. In mitochondrions there are important exchange processes among which the most important is oxidizing phosphorylation. Because of a lack of phospholipids the lipometabolism is broken that leads to fatty regeneration of a liver. Thanks to the pharmacological properties, drug normalizes these disturbances, promotes regeneration of subcellular and plasma membranes, reactivates the broken membrane-bound fermental systems and receptors, increases detoksikatsionny ability of a liver and thus normalizes its function.

Pharmacokinetics. At intake> 90% of drug are soaked up in a small intestine. The main quantity is split under influence fosfolipazy-A to 1-acyl-lizo-phosphatidylsincaline which 50% reatsilirutsya in polyunsaturated phosphatidylsincaline even during absorption in a small intestine at once. Polyunsaturated phosphatidylsincaline gets to blood in lymphatic ways and then, is preferential in a complex with LPVP, is transported in a liver. The maximum concentration of phosphatidylsincaline in a blood plasma in 6–24 h after reception averages 20% of the dose accepted inside. The elimination half-life for a choline component makes 66 h, for saturated fatty acids — 32 h. In kinetics researches at the person <5% of each of the entered H 3 and C14 isotopes were allocated with a stake.

Indications to use:

Fatty degeneration of a liver (including damage of a liver at a diabetes mellitus), acute and chronic hepatitis, before - and postoperative treatment at surgical interventions on a liver and biliary tract, toxic damages of a liver; gestosis of pregnant women, radiation syndrome.

Route of administration and doses:

At adults and teenagers the dose of drug makes on 1 capsule 3 times a day during food, without chewing, washing down with a small amount of water. Recommend drug use by a course not less than 3 months.

Features of use:

Drug can be used during pregnancy according to indications. There are no data on use during feeding by a breast.

Side effects:

In isolated cases unpleasant feelings in epigastric area are possible.

Interaction with other medicines:

Are not described.

Contraindications:

Hypersensitivity to drug components, an intra hepatic cholestasia, children's age up to 12 years.

Overdose:

There are no messages on drug overdose cases.

Storage conditions:

Drug is recommended to be stored in the dry place far from direct sunshine at a temperature from 15 to 25 degrees Celsius. A period of validity – 2 years.

Issue conditions:

According to the recipe

Packaging:

Capsules on 10 pieces in a blister strip packaging, on the 3rd blister strip packagings in a cardboard pack.