Gerovital

General characteristics. Structure:

Active agents: extract of fruits of a prickly hawthorn - 80 mg, motherwort grass extract - 50 mg, extract of a grass of a dog nettle – 50 mg, extract of flowers and leaves of a prickly hawthorn - 20 mg, ferrous lactate (bivalent) – 25 mg, vitamin C (ascorbic acid) - 450 mg, vitamin E (tocopherol acetate) - 60 mg, B12 vitamin (cyanocobalamine) - 5 mkg, vitamin A (Retinolum acetate) - 1450 ME, B2 vitamin (Riboflavinum) - 9 mg, B6 vitamin (a pyridoxine hydrochloride) - 9 mg, B1 vitamin (a thiamin hydrochloride) - 6 mg, niacinamide - 75 mg, D3 vitamin (cholecalciferol) - 12,5 mkg, a dekspantenola - 40 mg.

Excipients: alcohol-aqueous solution to 100 g (70%), citric acid, fragrance orange, cremophore, propylene glycol, E160e dye, butylhydroxyanisole, potassium sorbate, glycerin, sodium saccharin, ether of paragidroksibengzoynomatilovy acid, the purified water.

Pharmacological properties:

The mechanism of action of Gerovital (complex polyvitaminic drug with plant extracts and microelements) is caused by the ingredients included in its structure. Vitamins - compound components of important enzymes which regulate protein, lipidic and carbohydrate metabolism of substances. Also take participation in exchange of minerals. The lack of vitamins B a diet causes disturbance of metabolism of cells, decrease in a trophicity of fabrics, deterioration in regeneration and growth of cells and decrease in immunological protection of an organism.

Gerovital with plant extracts and minerals leads reception of a polyvitaminic complex to stabilization of cellular metabolism, improvement of a trophicity of fabrics, normalization of transformation of energy in cells, to ensuring correct work of immune system and the correct functioning of all bodies and systems. Gerovital's list included iron – the microelement necessary for an erythrogenesis. Iron is a part of hemoglobin and some important fabric enzymes. Plant extracts have biological activity concerning functions of nervous and cardiovascular systems. Extract of a hawthorn stabilizes cordial functions, reduces the increased arterial pressure, increases resistance of a cardiac muscle to hypoxemic conditions. Extract of a motherwort possesses soft sedation, reduces sensation of fear and concerns, reduces irritability and excitability. As Gerovital contains several active components, pharmacokinetic parameters were not studied.

Indications to use:

— prevention of a hypovitaminosis;

— the increased need for vitamins (the raised exercise and intellectual stresses, the recovery period after the postponed diseases, operative measures) especially at people of advanced age;

— asthenoneurotic states (as a part of complex therapy).

Route of administration and doses:

Gerovital to accept in time or before meal. A usual dosage – on 5 ml 2 times a day (1 tablespoon contains 5 ml of drug, or 14,96 g). The minimum term of therapy – 1 month. The course of treatment is established in each case by the attending physician.

Features of use:

Not to exceed the recommended dosage.

Drug contains 15% of alcohol. At each reception the patient receives 2.25 g of alcohol.

The concomitant use with other polyvitaminic drugs in order to avoid overdose is not recommended.

Coloring of urine in yellow color which is explained by existence in Riboflavinum drug, and disappearing upon termination of administration of drug is possible.

At storage the solution opacification which is not influencing quality of drug is possible. Before the use it is recommended to shake up.

Side effects:

Allergic reactions are possible.

Interaction with other medicines:

Against the background of Gerovital's reception efficiency of a levodopa decreases (due to inclusion in structure of a polyvitaminic complex of B6 vitamin). Vitamin A reduces a therapeutic effectiveness of betamethasone. Decrease in effect of B6 vitamin can be observed at parallel reception by the patient of such drugs as Penicillaminum, Cycloserinum and изоникотингидразид. Ascorbic acid exponentiates effects of salicylates. Ascorbic acid reduces expressiveness of effect of anticoagulants, tricyclic antidepressants, an izoprenalin, Fluphenazin and nitrofurantoin. Absorption of folic acid from Gerovital decreases at a combination with Trimethoprimum, Sulfasalazinum, Triamterenum, a methotrexate, Pyrimethaminum and means for treatment of epilepsy.

The means which are used for treatment of epilepsy strengthen metabolic transformations and elimination with bile of a kolekaltsiferol. Absorption of cyanocobalamine decreases at parallel reception of guanyl guanidines. The combination of Colestyraminum and laxative drugs on the basis of mineral oils causes reduction of comprehensibility of vitamins D, A and E. Efficiency of a pyridoxine also decreases against the background of reception of an isoniazid. Due to strengthening of elimination of zinc decrease in its content in blood in case of a combination to Phenytoinum, diuretics, Disulfiramum, Penicillaminum, glucocorticosteroids, Cimetidinum, tetracycline, captopril, Ethambutolum, valproic acid, an isoniazid and Mercaptopurinum can be observed. The estrogen which is contained in hormonal contraceptives can increase the content in blood of ascorbic acid and vitamin A and to reduce – the content of folates. Vinblastine, Cisplatinum, ftoruratsit and Bleomycinum worsen comprehensibility of vitamins of group B (1 and 6), and also vitamin A. Absorption of iron decreases at reception of not system antacids and tetracyclines. Under the influence of an isoniazid and Penicillaminum the strengthened removal of B1 vitamins from an organism is observed that can reduce efficiency of B1 vitamin in Gerovitale.

Contraindications:

— the increased content of iron in an organism;

— pregnancy period;

— children's age;

— hypersensitivity to drug components.

With care: the patient with liver diseases, epilepsy, injuries of a brain.

Overdose:

At the moment it was not reported about cases of exceeding of a dose of Gerovital. At overdose signs of hypervitaminoses are possible. Exceeding of a dosage of vitamin A can cause head pains, diarrhea, ostealgias, abdominal pains, a gepatosplenomegaliya, an alopecia, subperiosteal hemorrhages, a faint, nausea and vomiting. Niacinamide overdose – breath difficulty, skin rash, heartbeat increase, and a sudden massive potovydeleniye. Treatment – symptomatic. Exceeding of a dose of other components of Gerovital is almost impossible. At possible overdose of iron with need of a detoxication – Deferoxaminum.

Storage conditions:

To store at a temperature not above 25 °C. To store in the place, unavailable to children. A period of validity - 3 years.

Issue conditions:

Without recipe

Packaging:

30 ml - bottles of dark glass (1) - a pack cardboard.
50 ml - bottles of dark glass (1) - a pack cardboard.
100 ml - bottles of dark glass (1) - a pack cardboard.
200 ml - bottles of dark glass (1) - a pack cardboard.
200 ml - bottles (1) - packs cardboard.