Оксамсар®

General characteristics. Structure:

Active ingredients: 431 mg of ampicillin of sodium salt (375 mg of active agent are equivalent), 146,2 mg of Oxacillinum of sodium salt (125 mg of active agent are equivalent).

Pharmacological properties:

Pharmacodynamics. The combined antibiotic combining an action spectrum of an apitsillin and Oxacillinum.

Ampicillin - semi-synthetic penicillin, works bakteritsidno, кислотоустойчив. It is active concerning gram-positive, not forming a penicillinase (Staphylococcus spp., Streptococcus spp., Streptococcus pneumoniae) and gram-negative (Neisseria gonorrhoeae, Neisseria meningitidis. Escherichia coli, Salmonella spp., Shigella spp., Proteus mirabilis, Haemophilus influenzae) microorganisms.  

Oxacillinum - a penitsillinazoustoychivy semi-synthetic antibiotic from group of penicillin, кислотоустойчив; possesses bactericidal action concerning gram-positive microorganisms (Staphylococcus spp., Streptococcus spp., including Streptococcus pneumoniae, Actinimyces spp. Bacillus anthracis, Corynebacterium diphtheriae, anaerobic spore-forming sticks, including Clostridium), gram-negative cocci ( Neisseria gonorrhoeae, Neisseria meningitidis), E.coli, Pr.mirabilis, H.influenzae, K.pneumoniae, Actinomyces spp., Treponema spp. Ps.aeruginosa, etc. nonfermentative gram-negative bacteriums the majority of strains of Pr.vulgaris, Providencia rettgeri, Morganella morgami are steady against effect of drug

Pharmacokinetics. Time of achievement of the maximum concentration of both antibiotics in blood - 0.5-1ch. After introduction in oil. At in introduction to blood the concentration of drug exceeding those at in introduction are quickly created. Both antibiotics are removed by kidneys, partially with bile. At repeated introductions do not kumulirut

Indications to use:

The bacterial infections caused by sensitive activators: sinusitis, tonsillitis, average otitis; bronchitis, pneumonia; cholangitis, cholecystitis; pyelonephritis, pyelitis, cystitis, urethritis, gonorrhea, cervicitis; infections of skin and soft tissues: the ugly face, impetigo for the second time infected a dermatosis, etc. Prevention of postoperative complications at surgical interventions (including against the background of an immunodeficiency), infections at newborns (infection of amniotic liquid; the disturbance of breath of the newborn demanding use of resuscitation measures; danger of developing of aspiration pneumonia). Hard proceeding infections (sepsis, an endocarditis, meningitis, a puerperal infection)

Route of administration and doses:

In oil and in/in (struyno, kapelno), the daily dose for adults and children is more senior than 14 years - 3-6 g; for newborns premature and children till 1 year - 100-200 mg/kg/days; 1-6 years - 100 mg/kg/days; 7-14 years - 100 mg/kg/days. The daily dose is entered into 3-4 receptions, with an interval of 6-8 h. If necessary the specified doses can be increased by 1.5-2 times.

For introduction in oil bottle contents (0.2 and 0.5 g) are dissolved, respectively, in 2 and 5 ml of water for injections. For in/in jet introductions (within 2-3 min.) dissolve a single dose in 10-15 ml of water for injections or 0.9% of solution of sodium of chloride.

For in/in drop introductions by the adult a single dose dissolve 0.9% of NaCl solution or 5% of solution of a dextrose in 100-200 ml and enter with a speed of 60-80 of caps/mines; to children as solvent use 30-100 ml of 5%-10% of solution of a dextrose. Enter into drug 5-7 days, with the subsequent transition on in oil or oral administration.

Solutions use right after preparation.

Contraindications:

Hypersensitivity, infectious mononucleosis, lymphoid leukosis.

Storage conditions:

Period of validity 2 years. Not to use after expiry date. List B. In the dry, protected from light place at a temperature below 20 °C. To store in the place, unavailable to children.

Issue conditions:

According to the recipe

Packaging:

Powder for preparation of solution for injections in bottles on 0,5 g. On 50 bottles with the application instruction in a cardboard pack