Ampicillin, Oxacillinum - Borimed

General characteristics. Structure:

Active ingredient: 125 mg of ampicillin, 125 mg of Oxacillinum in 1 capsule.

Excipients: potato starch, icing sugar, calcium stearate or stearic acid.

Pharmacological properties:

Pharmacodynamics. Drug combines ranges of antimicrobic effect of ampicillin and Oxacillinum. Works on gram-positive (staphylococcus, a streptococcus, the pneumocook) and gram-negative (гонокок, менингокок, colibacillus, Pfeyfer's stick, salmonellas, shigellas and others) microorganisms. Thanks to Oxacillinum contents drug is active rather penitsillinazoobrazuyushchy stafilokokk.

Pharmacokinetics. Ampicillin is well soaked up in blood at use inside, the maximum concentration is reached in 2 hours. Drug is observed in blood during the 6th hour. In insignificant quantity contacts proteins of a blood plasma. Ampicillin gets into liquor in the minimum quantities (0,25-0,5% of concentration in blood serum), is observed in pleural and synovial to liquids (65 - 80% of concentration in blood serum), in bile. Out of an organism it is brought in steady-state condition by kidneys of 75 - 90% of ampicillin.

Oxacillinum is well soaked up at use inside, the concentration maximum in blood is reached in 1 - 2 hour after introduction and quickly decreases to the 4th hour. After 1 - 3 hour after reception Oxacillinum is observed in pleural liquid in concentration that reaches 10%, in synovial and ascitic to liquids – 50%, in bile of 5-8% of concentration in blood serum. 23-75% of Oxacillinum are removed with urine. In an organism to 10% of an antibiotic it is metabolized. Products of metabolism of drug keep antibacterial activity.

Indications to use:

Drug is appointed at respiratory infections (bronchitis, pneumonia), at quinsies, cholangites, cholecystitis, pyelonephritis, cystitis, contaminated wounds, skin infections, burns), at an undetected antibiotikogramma and not allocated activator, at the multi-infections caused sensitive and insensitive to benzylpenicillin of a stafilokokkama and gram-negative bacteria.

At treatment of gonorrhea Ampicillin, Oksatsillin-Borimed use in the cases caused by strains of gonokokk, resistant to benzylpenicillin.

Route of administration and doses:

It is applied inside. The single dose for adults and children is more senior than 14 years makes 0,5 - 1, daily 2 - 4 g. The daily dose is divided into 4 - 6 receptions. The term of treatment is from 5 - 7 days up to 2 weeks and more.

Features of use:

Children age up to 14 years are recommended to use drug in other dosage form. With care appoint during pregnancy. It is not recommended during chest feeding.

At long use systematic control of function of kidneys is necessary, for a liver. In the weakened patients at long use development of the superinfection caused by microorganisms, resistant to drug, is possible.

Side effects:

At administration of drug nausea, vomiting, diarrhea, allergic reactions can be observed inside.

Interaction with other medicines:

At simultaneous use of drug with:

- beta adrenoblockers the probability of anafilaksiya increases,

- with contraceptives - efficiency of a contraceptive decreases,

- with chloramphenicol, tetracyclines, erythromycin - the effect of both drugs decreases.

Contraindications:

Toksiko-allergichesky reactions to drugs of group of penicillin.

Overdose:

In case of overdose nausea, vomiting, diarrhea can be observed.

Treatment – symptomatic.

Storage conditions:

To store in the unavailable to children, dry, protected from light place at a temperature + 15 - 25 °C. A period of validity - 2 years.

Issue conditions:

According to the recipe

Packaging:

On 10 capsules in strip packagings, on 2 strip packagings in a cardboard pack.