Ампиокс®

General characteristics. Structure:

Active ingredients: 0,125 g Ampicillini trihdras (in terms of ampicillin), 0,125 g of Oxacillinum sodium salt (in terms of Oxacillinum).

Excipients: potato starch, sugar (sucrose), talc, magnesium stearate, primelloz.

Structure of the capsule: gelatin, titanium dioxide.

Pharmacological properties:

Pharmacodynamics. The combined antibiotic combining an action spectrum of an ampiyotsillin and Oxacillinum.

Ampicillin - semi-synthetic penicillin, works bakteritsidno, кислотоустойчив. It is active concerning gram-positive, not forming a penicillinase (Staphylococcus spp., Streptococcus spp., Streptococcus pneumoniae) and gram-negative (Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Salmonella spp., Shigella spp., Proteus mirabilis, Haemophilus influenzae, Haemophilus influenzae) microorganisms.

Oxacillinum - a penitsillinazoustoychivy semi-synthetic antibiotic from group of penicillin, кислотоустойчив; possesses bactericidal deystviyoy concerning gram-positive microorganisms (Staphylococcus spp., Streptococcus spp., including Streptococcus pneumoniae, Actinimyces spp., Bacillus anthracis, Corynebacterium diphtheriae, anaerobic spore-forming sticks, including Clostridium), gram-negative cocci (Neisseria gonorrhoeae, Neisseria meningitidis), E.coli, Pr.mirabilis, H.influenzae, K.pneumoniae, Actinomyces spp, Treponema spp.

Pharmacokinetics. Both antibiotics are removed by kidneys, partially with bile. At repeated introductions do not kumulirut.

Indications to use:

The bacterial infections caused by sensitive activators: siyonusit, tonsillitis, average otitis; bronchitis, pneumonia; cholangitis, cholecystitis; pyelonephritis, pyelitis, cystitis, urethritis, gonorrhea, cervicitis; infections of skin and soft tissues: the ugly face, impetigo for the second time infected a dermatosis, etc.

Prevention of postoperative complications at surgical vmeyoshatelstvo (including against the background of an immunodeficiency), infections at newborns (infection of amniotic liquid; the disturbance of breath of the newborn demanding use of resuscitation measures; danger of developing of aspiyoratsionny pneumonia).

Hard proceeding infections (sepsis, endocarditis, meningitis, posleroyodovy infection).

Route of administration and doses:

Inside. The single dose for adults and children is more senior than 14 years - 0.5-1 g, daily - 2-4 g. Children are 3-7 years old - 100 mg/kg/days, 7-14 - 50 mg/kg/days.

Treatment duration - from 5-7 days to 2 weeks. The daily dose is divided into 4-6 receptions.

Features of use:

Pregnancy and lactation. Use at pregnancy according to indications is possible. It is allocated with breast milk in low concentration. At a neobkhodiyomost of use of drug in the period of a lactation it is necessary to resolve an issue of a breastfeeding preyokrashcheniya.

At course treatment it is necessary to carry out by drug control of a soyostoyaniye of function of bodies of a hemopoiesis, a liver and kidneys.

The possibility of development of superinfection (due to growth of microflora, insensitive to it) demands corresponding change of antibacterial therapy.

At the patients having hypersensitivity to penicillin cross allergic reactions with tsefalosporinovy antiyobiotika are possible.

At use of high doses for patients with a renal failure perhaps toxic action on the central nervous system.

Side effects:

Allergic reactions: a small tortoiseshell, a dermahemia, a Quincke's edema, riyonit, conjunctivitis; fever, arthralgia, eosinophilia, in rare instances anayofilaktichesky shock; superinfection, dysbacteriosis, taste change, vomiting, nausea, diarrhea, seldom pseudomembranous coloenteritis, leukopenia, neutropenia, anemia.

At emergence of signs of an acute anaphylaxis there have to be prinyayota urgent measures for removal of the patient from this state: introduction of Epinephrinum, glucocorticosteroids (a hydrocortisone or Prednisolonum) and antihistamines, if necessary carry out artificial ventilation of the lungs.

Interaction with other medicines:

Antacids, glycosamine, purgatives, food, aminoglycosides - slow down and reduce absorption; ascorbic acid increases drug absorption.

Bactericidal antibiotics (including aminoglycosides, cephalosporins, Vancomycinum, rifampicin) have sinergidny effect; bakteriostaticheyosky drugs (macroleads, chloramphenicol, linkozamida, tetracyclines, streptocides) - antagonistic.

Increases efficiency of indirect anticoagulants (suppressing kishechyony microflora, reduces synthesis of vitamin K and a prothrombin ratio); reduces efficiency of oral contraceptives, medicines in the course of which metabolism the paraaminobenzoic kiyoslota, ethinylestradiol - risk of development of bleedings of "break" is formed.

Diuretics, Allopyrinolum, phenylbutazone, nonsteroid protivovospaliyotelny drugs, пробенецид - reducing canalicular secretion, increase concentration of drug in plasma that increases risk of development of toxic action.

Allopyrinolum increases risk of development of skin rash.

Contraindications:

Hypersensitivity, infectious mononucleosis, lymphoid leukosis.

With care: to the children who were born at mothers with the raised chuvstvitelyyonost to penicillin.

Storage conditions:

List B. In the dry, protected from light place at a temperature not above 25 °C. To store in the place, unavailable to children. A period of validity - 2 years. Not to use after expiry date.

Issue conditions:

According to the recipe

Packaging:

Capsules of 250 mg (0,125 g of ampicillin and 0,125 g of Oxacillinum). On 20 capsules in bank of orange glass or in bank from glass melt. On 20 capsules in bank of polymeric. On 10 capsules in a blister strip packaging. Bank or 1, 2 blister strip packagings with the application instruction - in a pack from a cardboard.