Tubercular intoxication

Description:

Distinguish tubercular intoxication as a syndrome characteristic of all forms of tuberculosis  and as an independent form of this disease at children and teenagers (tubercular intoxication at children and teenagers).
Tubercular intoxication at children and teenagers represents a form of active primary tuberculosis at which local specific defeats by means of radiological and other methods of a research are not found.
This form of tuberculosis comes to light at children and teenagers with a bend of tuberkulinovy reactions and giperergichesky reactions to tuberculine.

Symptoms of Tubercular intoxication:

Clinically it is characterized by deterioration in the general condition of the child (teenager) that is expressed by periodic fervescence to subfebrile figures, a loss of appetite, emergence of neurovegetative frustration (the increased nervous irritability or block, a headache, tachycardia). Physiological increase of body weight stops or there is its deficit. Often intercurrent diseases develop: acute respiratory viral infections, etc. Small increase in peripheral lymph nodes of almost all localizations (6 — 9 groups) — a micropolyadenia is characteristic; in each group multiple lymph nodes with a diameter of 0,5 — 1,5 cm, elastic or dense as the "stones" which are often soldered among themselves and surrounding fabrics painless are palpated. Slightly the liver increases, at a palpation edge its acute, painless. Increase in a spleen is less often observed. At a blood analysis reveal unsharply expressed leukocytosis and increase in SOE, shift of a blood count to the left, an eosinophilia, a lymphopenia. Confirm decrease in number of T lymphocytes in blood, suppression of a blastotransformation of lymphocytes with phytohemagglutinin and tuberculine change of the immunological status, growth of level of specific antibodies. In lungs it is fizikalno and radiological not possible to find the expressed changes of specific character. However in some cases strengthening of the pulmonary drawing in a radical zone is noted that is caused, apparently, by congestive and inflammatory changes in lymphatic system.
In modern classification of the main clinical forms of tuberculosis there is no former division of tubercular intoxication at children and teenagers on early and chronic since in connection with a pathomorphism expressiveness of a symptom complex of functional frustration decreased, and extent of involvement of lymphatic system and change of the indicators of the immunological status testimonial of activity of a tuberculosis infection, in the early and late period approached.

Reasons of Tubercular intoxication:

Is caused by tuberculosis mycobacteria.

Treatment of Tubercular intoxication:

For treatment of tubercular intoxication purpose of an isoniazid and Ethambutolum or sodium of paraaminosalicylate against the background of the desensibilizing therapy and vitamin therapy is shown long (not less than 6 months). The long chemotherapy not only promotes permanent disappearance of tubercular intoxication, but also prevents development of local forms of tuberculosis (at the children who received chemotherapy, they are observed by 6 times less than at not treated). The chemotherapy in sanatorium conditions is more effective.
Children and teenagers at whom tubercular intoxication is revealed are observed in the I group of the accounting of an antitubercular clinic within a year, then in the III (control) group within a year then in the absence of displays of tuberculosis are struck off the register.
For prevention of tubercular intoxication children need to carry out preventive treatment by an isoniazid from risk groups: with a bend of tuberkulinovy reactions, a hyperergy to tuberculine, strengthening of tuberkulinovy sensitivity contacting to the TB patient, to the infected children with diseases of a respiratory organs.