Chloropyraminum

General characteristics. Structure:

Active agent: Chloropyraminum a hydrochloride - 20 mg;
excipients: water for injections.

Chemical name: N-dimetilaminoetil-N-(para-chlorbenzylium) - aminopyridine a hydrochloride.

Description. Transparent, colourless or slightly yellowish or slightly greenish solution with a characteristic smell.

Pharmacological properties:

Pharmacodynamics. Chloropyraminum is H1 blocker - receptors. On a chemical structure treats ethylene diamine derivatives. Chloropyraminum selectively inhibits histamine H1 - receptors and reduces permeability of capillaries. Prevents development and facilitates the course of allergic reactions. Has the sedative and expressed antipruritic effect. Has moderate peripheral anticholinergic and spasmolytic activity and antiemetic action.

Pharmacokinetics. Absorption: Concentration in blood reaches a maximum during 2 h and remains at the therapeutic level for 4 - 6 h.

Distribution: It is evenly distributed in an organism, gets through a blood-brain barrier. Communication of Chloropyraminum with proteins of a blood plasma makes 7,9%. The peak of binding is noted at рМ 6,8-7,4.

Removal: It is metabolized in a liver, removed preferential through kidneys with urine in the form of metabolites.

Indications to use:

Allergic diseases, including urticaria, rhinitis, conjunctivitis, pollinosis (hay fever), Quincke's disease, serum disease, medicinal allergy, skin diseases, including eczema, contact dermatitis, skin itch, neurodermatitis, toksikodermiya.

Route of administration and doses:

Intramusculary or intravenously.

Adult appoint 20-40 mg a day (contents of 1-2 ampoules).

Treatment at children begin 5 mg (0,25 ml) with a dose. Further increase in a dose is limited preferential by emergence of side effects.

To children at the age of 1-12 months - 5 mg (0,25 ml).

To children at the age of 2-6 years of-10 mg (0,5 ml).

To children at the age of 7-14 years-10-20 mg (0,5-1 ml).

The daily dose should not exceed 2 mg/kg of body weight.

At the heavy course of an allergy treatment should be begun with an injection form of Chloropyraminum. At first it is entered intravenously slowly, then passed to intramuscular introduction and in a final phase of treatment passed to reception of tablets inside.

Features of use:

The patients accepting Chloropyraminum are recommended to abstain from driving of vehicles, work with mechanisms, and also from other types of activity demanding the increased concentration of attention and speed of psychomotor reactions. During treatment the use of alcoholic beverages is not recommended.

Side effects:

Weakness, drowsiness, dizziness, incoordination of movements, dryness in a mouth, nausea, diarrhea, is more rare difficulty of an urination, a lowering of arterial pressure, tachycardia, arrhythmia, a gastralgia, allergic reaction to drug, a photosensitization, increase in intraocular pressure.

Interaction with other medicines:

Strengthens effect of medicines for the general anesthesia, hypnotic drugs, sedative medicines, opioid analgetics, local anesthetics.

Tricyclic antidepressants strengthen M-holinoblokiruyushchee and the oppressing action on the central nervous system.

Caffeine and Phenaminum reduce the oppressing action by the central nervous system.

It is not compatible to ethanol.

Contraindications:

- Individual hypersensitivity to drug.
- Simultaneous use of monoamine oxidase inhibitors.
- Newborn children.
- Pregnancy and period of a lactation.
- A peptic ulcer of a stomach in an aggravation stage.
- Closed-angle glaucoma.
- Prostate hyperplasia.
- Respiratory insufficiency.

Patients of advanced age should appoint drug with care, at insufficiency of function of a liver and/or heart diseases, at a round ulcer of digestive tract, at reception of the medicines oppressing the central nervous system.

Overdose:

Symptoms: children have an excitement, uneasiness, hallucinations, an athetosis, an ataxy, spasms, a mydriasis, an immovability of pupils, a dermahemia of the person, a hyperthermia; then - a vascular collapse, a coma. Adults have a block, a depression, a hyperthermia and a hyperemia of integuments, psychomotor excitement, spasms, a coma. Treatment: a gastric lavage, reception of absorbent carbon (when carrying out a detoxication in early terms after oral administration); symptomatic therapy (including purpose of antiepileptic means, caffeine, Phenaminum), resuscitation actions, artificial ventilation of the lungs - according to indications.

Storage conditions:

Period of validity - 3 years. Ne to use after the period of validity specified on packaging. List B. In the place protected from light at a temperature not above 25 °C. To store in the place, unavailable to children.

Issue conditions:

According to the recipe

Packaging:

Solution for intravenous and intramuscular administration of 20 mg/ml.

On 1 ml in ampoules. On 5 ampoules in a blister strip packaging. On 1 or 2 blister strip packagings together with the application instruction in a pack from a cardboard.