Rutaskorbin

General characteristics. Structure:

Active ingredient: 50 mg of ascorbic acid, 50 mg of Rutinum.

The combined drug? dosstanavlivayushchy a vitamin deficiency With and River.

Pharmacological properties:

Pharmacodynamics. Ascorbic acid fills shortage of vitamin C in an organism, has metabolic, antioxidant effect, participates in regulation of carbohydrate metabolism, coagulability of blood, an angenesis and metabolism of iron, promotes increase in body resistance.

Rutoside concerns to group of vitamin P. Eliminating a hyperpermeability of capillaries, strengthens a vascular wall, reduces its puffiness and an inflammation. Possesses antiagregantny action that promotes microcirculation improvement.

Pharmacokinetics. After intake ascorbic acid is absorbed preferential in a jejunum. Absorption decreases at the use of fresh fruit and vegetable juice, alkaline drink. In 30 minutes after reception the content of ascorbic acid considerably increases and turns into hydroascorbic acid. Further gets through cellular membranes in cells where it is quickly recovered.

Collects generally in cells in three forms: ascorbic, dehydroascorbic acids and askorbigena (combined ascorbic acid). Easily gets into leukocytes, thrombocytes, and then – into other body tissues; it is deposited in a back share of a hypophysis, bark of adrenal glands, an eye epithelium, interstitial cells of seminal glands, ovaries, a liver, a brain, a spleen, a pancreas, lungs, kidneys, an intestines wall, heart, muscles, a thyroid gland.

Gets through a placenta. It is metabolized, it is preferential in a liver (to 90%), in dezoksiaskorbinovy acid and further – in oxalacetic and diketo-gulonic acids. Not changed ascorbic acid and metabolites are emitted with urine, and also with a stake, then and breast milk. At use of high doses when concentration in plasma reaches more than 1,4 mg/dl, removal sharply amplifies.

Rutoside promotes transport and deposition of ascorbic acid. At intake the maximum concentration of rutoside in blood is reached in 1 - 4 h. It is allocated in the form of metabolites and in not changed look, mainly with bile, to a lesser extent – with urine. The elimination half-life makes 10-25 hours.

Indications to use:

Hypo - and avitaminosis of ascorbic acid and Rutinum; as a part of complex therapy at a varicosity with painful and edematous syndromes, superficial thrombophlebitis, trophic disturbances and ulcers, chronic venous insufficiency; hemorrhagic diathesis; at defeats of the capillaries caused by use of anticoagulants and salicylates as preventive and remedy.

Route of administration and doses:

Drug is accepted inside it is desirable after meal. For treatment by the adult appoint on 1 tablet 2-3 times a day; to children 3 years on 1 tablet 2 times a day are more senior.

As prophylactic about 1 tablet 2 times a day is recommended to adults; to children 3 years on 1 tablet of 1 times a day are more senior.

Duration of treatment is 3-4 weeks depending on the nature of a disease and efficiency of treatment.

Features of use:

Pregnancy and lactation: Use of drug at pregnancy and in the period of a lactation according to indications is possible. With care appoint in the I trimester of pregnancy.

Drug does not exert impact on ability to drive the car and potentially dangerous mechanisms.

At prolonged use of drug (more than 4 weeks) it is not necessary to appoint along with cardiac glycosides, anti-hypertensive means and non-steroidal anti-inflammatory drugs because of strengthening of their action.

At long administration of drug it is necessary to control function of kidneys, level of arterial pressure and concentration of glucose in blood.

Side effects:

Allergic reactions (skin rash), dispepsichesky frustration (nausea, vomiting, abdominal pains, diarrhea), increase in arterial pressure, sleep disorder, headache.

Interaction with other medicines:

Ascorbic acid increases level in blood of salicylates, ethinylestradiol, benzylpenicillin and tetracyclines, reduces the level of oral contraceptives.

Improves absorption in intestines of iron preparations. Accelerates removal of alcohol, amphetamine and tricyclic antidepressants.

Reduces efficiency of heparin and indirect anticoagulants.

Reduces therapeutic action of an izoprenalin and neuroleptics - derivatives of a fenotiazin. In high doses increases removal of a meksiletin kidneys.

Drugs of a quinolinic row, Calcii chloridum, salicylates, glucocorticosteroids at prolonged use exhaust reserves of ascorbic acid.

Barbiturates and Primidonum increase removal of ascorbic acid with urine.

Contraindications:

The increased individual sensitivity to drug components. The increased coagulability of blood, thrombophlebitises, tendency to fibrinferments.

With care appoint at deficit glyukozo-6-fosfatdegidrogenazy, hemochromatosis, sideroblastny anemia, a thalassemia, a hyperoxaluria, an oxarod, an urolithiasis.

With care appoint at diabetes and diseases of kidneys.

Overdose:

Symptoms: a headache, inflows, increase in excitability of the central nervous system, sleeplessness, disturbances from digestive tract (abdominal pains, nausea, vomiting, diarrhea), a thrombogenesis, oppression of function of the insulyarny device of a pancreas

Treatment: symptomatic therapy.

Issue conditions:

According to the recipe

Packaging:

Tablets in a blister strip packaging No. 10х2, No. 10x5.