Flebodia 600

General characteristics. Structure:

Active ingredient: Diosmin in terms of dry matter of 600 mg;

Excipients: talc of 10,24 mg; silicon dioxide of colloid 3,5 mg; stearic acid of 50,05 mg; cellulose microcrystallic to 910 mg;

Structure of a film cover:
ÆÑ»¿õ¿½¼® 002 (a gipromelloza (Е 464) - 9,832 mg, cellulose microcrystallic - 7,866 mg, a macrogoal the 8th stearate type 1 - 1,967 mg). Сеписперс® AP 5523 pink (propylene glycol - traces, a gipromelloz (Е 464) - 0,458 mg, titanium dioxide (Е 171) - 4,026 mg, dye crimson [Ponso 4R] (E 124) - 0,401 mg, ferrous oxide black (Е 172) - 0,130 mg, ferrous oxide red (Е 172) - 0,020 mg). Опаглос® 6000 (wax of karnaubskiya (E 903) - 0,075 mg, beeswax (E 901) - 0,075 mg, shellac (E 904) - 0,150 mg, ethanol 95 ° - traces).

Description: round biconvex tablets, film coated pink color.

Pharmacological properties:

Drug possesses flebotoniziruyushchy action (reduces distensibility of veins, raises a tone of veins (dozozavisimy effect), reduces venous stagnation), improves a lymphatic drainage (raises a tone and frequency of reduction of lymphatic capillaries, increases their functional density, reduces lymphatic pressure), improves microcirculation (increases capillary resistance (dozozavisimy effect), reduces their permeability), reduces adhesion of leukocytes to a venous wall and their migration in paravenous fabrics, improves diffusion of oxygen and perfusion in skin fabric, possesses antiinflammatory action. Strengthens vasoconstrictive effect of adrenaline, noradrenaline, blocks development of free radicals, synthesis of prostaglandins and thromboxane.

Pharmacokinetics. It is quickly soaked up from digestive tract, it is found in plasma in 2 hours after reception. The maximum concentration in a blood plasma is reached in 5 hours after reception. Evenly is distributed and collects in all layers of a wall of venas cava and saphenas of the lower extremities, to a lesser extent - in kidneys, a liver and light and other fabrics. Selective accumulation of diosmin and/or its metabolites in venous vessels reaches a maximum by the 9th o'clock after reception and remains within 96 hours. It is removed by kidneys of 79%, intestines - 11%, with bile - 2,4%.

Indications to use:

Varicosity of the lower extremities, chronic lymph - venous insufficiency of the lower extremities; hemorrhoids; microcirculation disturbances.

Route of administration and doses:

For intake.
At a varicosity of the lower extremities and in an initial stage of chronic lympho-venous insufficiency (weight in legs) appoint on 1 tablet a day in the morning on an empty stomach within 2 months, at severe forms of chronic lympho-venous insufficiency (hypostases, pains, spasms, etc.) - continue treatment within 3 - 4 months, in the presence of trophic changes and ulcers prolong a course up to 6 months and more. The course is repeated in 2-3 months.
At an exacerbation of hemorrhoids appoint 2-3 tablets a day during food within 7 days, further if necessary it is possible to continue on 1 tablet 1 of times a day within 1 - 2 months.
At treatment of chronic lympho-venous insufficiency during II and III trimesters of pregnancy appoint on 1 tablet once a day. The termination of administration of drug in 2-3 weeks prior to childbirth.
If you missed one or several receptions continue use of drug in a usual dose.

Features of use:

Treatment of a bad attack of hemorrhoids is carried out in a complex with other drugs, in the absence of bystry clinical effect it is necessary to conduct additional examination and to correct the carried-out therapy.
There are data on possible efficiency of drug at treatment of fetoplacental insufficiency, for prevention of the bleedings arising at use of an intrauterine spiral and during the period after a phlebectomy.

Influence on ability to manage vehicles 
There are no data on negative influence of drug on ability to manage vehicles and other mechanisms.

Side effects:

In rare instances hypersensitivity to drug components demanding a break in treatment: from digestive tract - dispeptic frustration, from the central nervous system - a headache. If any of the side effects specified in the instruction are aggravated, or you noticed any other side effects which are not specified in the instruction, report about it to the doctor.

Interaction with other medicines:

Clinically significant effects of interaction with other medicines are not described.

Contraindications:

Hypersensitivity to drug components, the lactation period, children's age up to 18 years.

Pregnancy and breastfeeding
Still in clinical practice there were no messages on any side effects at use of drug for pregnant women. In pilot studies teratogenic impact on a fruit was not revealed. During breastfeeding administration of drug since there are no data on penetration of drug into breast milk is not recommended.

Overdose:

Symptoms of overdose are not described.

Storage conditions:

Period of validity 3 years. Not to use after a period of validity. To store at a temperature not above 30 °C. To store in the place, unavailable to children.

Issue conditions:

According to the recipe

Packaging:

Tablets are film coated. On 15 tablets in PVC / the aluminum blister. 1 or 2 blisters with the application instruction in a cardboard pack.