Венолек®

General characteristics. Structure:

Active agent — diosmin of 500 mg.

Excipients: a hypro rod (hydroxypropyl cellulose), calcium hydrophosphate a dihydrate, magnesium stearate, sodium carboxymethylstarch (sodium starch glycollate), cellulose microcrystallic, seleknut AQ–01812: gipromelloz (gidroksipropilmetiltsellyuloz), macrogoal (polyethyleneglycol 400), macrogoal (polyethyleneglycol 6000), titanium dioxide, ferrous oxide yellow, quinolinic yellow.

Description: tablets, film coated from light yellow till yellow color, round, a biconvex form. On a break of a tablet of yellow or grayish-yellow color.

Pharmacological properties:

Pharmacodynamics. Active agent of drug — diosmin concerns to group of natural biologically active compounds. Also flavonoids — hesperidin are a part of drug. Drug has angioprotektorny and venotoniziruyushchy effect. Reduces distensibility of veins, raises their tone and reduces venous stagnation; reduces permeability, fragility of capillaries and increases their resistance; improves microcirculation and a lymph drainage. At systematic use reduces expressiveness of clinical manifestations of chronic venous insufficiency of the lower extremities.

Pharmacokinetics. The elimination half-life makes 11 h. It is removed by intestines, kidneys.

Indications to use:

Symptomatic therapy of venous insufficiency of the lower extremities: heavy feeling and onychalgia.

Symptomatic therapy of acute hemorrhoids.

Route of administration and doses:

Inside during food.

At venous insufficiency — on 2 tablets a day (at noon and in the evening).

At acute hemorrhoids — 6 tablets a day (on 3 tablets 2 times) during the first 4 days, then 4 tablets a day (on 2 tablets 2 times) within 3 days.

Features of use:

At an exacerbation of hemorrhoids purpose of this drug does not replace specific treatment of other symptoms of hemorrhoids. Duration of treatment has to be short. If short therapy does not give positive effect, it is necessary to conduct a proctologic research and to reconsider the applied therapy.

Side effects:

Diarrhea, dyspepsia, nausea, vomiting; dizziness, headache, indisposition; allergic reactions (skin rash, itch, small tortoiseshell).

Interaction with other medicines:

It was not noted.

Contraindications:

Hypersensitivity, lactation period. Children's age up to 18 years.

Pregnancy and period of breastfeeding:

At pregnancy use of drug is possible. Pilot and clinical trials did not show embriotoksichesky, mutagen and teratogenic action.

So far there were no messages on any undesirable effects at use of drug for pregnant women, however pregnant women need to estimate risk and advantage at purpose of drug.

At a lactation administration of drug is not recommended due to the lack of data on penetration of drug into breast milk.

Overdose:

Now about cases of overdose of drug it was not reported.

Storage conditions:

List B. To store in the dry, protected from light place at a temperature not above 25 °C. To store in the place, unavailable to children. Period of validity 2 years. Not to apply after a period of validity.

Issue conditions:

According to the recipe

Packaging:

Tablets, film coated, 500 mg.

On 10 or 15 tablets in a blister strip packaging from a film of the polyvinyl chloride and printing aluminum foil varnished.

On 1, 3, 5, 6 blister strip packagings on 10 tablets or on 2, 4 blister strip packagings on 15 tablets together with the application instruction place in a pack from a cardboard for a retail container.