Detraven

General characteristics. Structure:

Active ingredient: 500 mg of mix of diosmin-hesperidin (90:10) in terms of the general maintenance of flavonoids.

Excipients: gelatin, talc, magnesium stearate, sodium glikolit starch, cellulose microcrystallic, Opadray 200 F (the polyvinyl alcohol which is partially hydrolyzed titanium dioxide, talc, Makrogol 3350 (Polyethyleneglycol), copolymer of methacrylic acid type C, ferrous oxide yellow,   E 172, ferrous oxide red, E 172, sodium bicarbonate, ferrous oxide black, E 172).

Pharmacological properties:

Pharmacodynamics. Medicine Detraven has venotoniziruyushchy and angioprotektorny properties. Drug reduces distensibility of veins and venous stagnation, reduces permeability of capillaries and increases their resistance, improves a lymphatic drainage, increases lymphatic outflow.

The optimum ratio of a dose and effect is observed at reception of 2 tablets. The therapeutic effectiveness at treatment of functional and organic chronic venous insufficiency of the lower extremities is proved, and also in a proctology at treatment of hemorrhoids.

Pharmacokinetics. Medicine supports the cleared flavanoidny fraction of diosmin and hesperidin in the micronized look, i.e. particle sizes of active agent are reduced that provides active absorption of medicine and more quick start of action.

Absorption. In digestive tract diosmin is quickly processed by pristenochny (intenstinalny) microflora and absorbed in blood in the form of an aglikon - a diosmetin, soluble in lipids. Not processed forms of diosmin are not absorbed.

Distribution. Diosmetin is very quickly redistributed by blood on fabrics. Animal experiments with use of diosmin with a radioactive label showed wide distribution of its metabolites on all organism.

The maximum concentration of a diosmetin in blood is observed in 1-3 hours after oral administration of diosmin.

Metabolism. Drug is extensively metabolized that is confirmed by existence in urine of various phenolic acids.

Removal. Release of drug happens generally to a stake; allocation with urine averages 14% of the accepted dose. The elimination half-life makes 11 hours.

Indications to use:

- treatment (as a part of complex therapy) symptoms of venous and lymphatic insufficiency (weight, puffiness and an onychalgia, trophic disturbances);

- treatment (as a part of complex therapy) the symptoms connected with a bad attack of hemorrhoids.

Route of administration and doses:

Treatment of symptoms of venous insufficiency: on 2 tablets a day (at noon and in the evening) during food.

Acute hemorrhoids: first 4 days: 6 tablets a day (3 tablets in the morning and 3 tablets in the evening). Next 3 days: 4 tablets a day (2 tablets in the morning and 2 tablets in the evening). To apply during food.

Features of use:

At bad attacks of hemorrhoids reception of this drug does not replace special treatment of other diseases of anorectal area. Treatment has to be appointed a short course. If symptoms do not pass quickly, it is necessary to conduct proctologic examination and to reconsider treatment.

At the frustration influencing venous blood circulation, treatment has the maximum effect at the balanced way of life. Avoid long stay in the sun, long standing standing, increase in body weight. Foot walks improve blood circulation. Patients should observe strictly the additional medical measures appointed by the doctor, such as wearing compression medical jersey (golfs, stockings), compresses, a cool shower on area of the lower extremities, etc.

Use for children. Not to apply at children.

Use during pregnancy or feeding by a breast. During the numerous researches of teratogenic effect it was revealed not and messages on the undesirable phenomena at the person did not arrive. In view of lack of data on drug excretion in breast milk, feeding by a breast during treatment should be avoided.

Ability to influence speed of response at control of motor transport or other mechanisms. Drug does not influence ability to driving of motor transport and performance of the work demanding the high speed of psychomotor reactions.

Side effects:

Messages on the following side effects or the phenomena were received, frequency is specified depending on occurrence of a case: very often (> 1/10), it is frequent (<1/10 and> 1/100), infrequently (<1/100 and> 1/1000), is rare (<1/1000 and> 1/10000), is very rare (<1/10000), not specified frequency (it is impossible to carry out assessment on the basis of the available data).

From a nervous system: seldom - dizziness, a headache, a febricula.

From the alimentary system: often - diarrhea, nausea, vomiting, dyspepsia; infrequently - colitis.

Disturbances from integuments and hypodermic fabric: seldom - rash, an itch, urticaria; not specified frequency - the isolated face edema, lips, a century; in exceptional cases - a Quincke's disease.

Interaction with other medicines:

Researches of interaction were not conducted. At the same time, in view of extensive post-marketing experience with similar drugs, about medicinal interactions it was not reported.

Contraindications:

Hypersensitivity to active agent or any of excipients.

Overdose:

Messages on cases of overdose did not arrive.

Storage conditions:

In the place protected from light and moisture, at a temperature not above 30 °C. To store in the place, unavailable to children. A period of validity - 2 years. Not to use medicine after the termination of a period of validity.

Issue conditions:

Without recipe

Packaging:

On 10 tablets in a blister strip packaging. 3 or 6 blister strip packagings with a leaf insert in a pack from a cardboard.