Trokserutin-Darnitsa

General characteristics. Structure:

Acting veshchestvo:troxerutin;

1 g of gel contains a trokserutin of 20 mg;

excipients: methylparahydroxybenzoate (Е 218), propylene glycol, carbomer 980, трометамол, dinatrium эдетат, the water purified.

Pharmacological properties:

Trokserutin has angioprotektorny and flebotoniziruyushchy effect.

The main place of accumulation of drug is the endothelial layer of venules. Drug deeply gets into a subendothelial layer of a venous wall where concentration is higher than it, than in the next fabrics.

Drug prevents the damage of cellular membranes caused by oxidation. The antioxidant effect is shown in decrease and elimination of oxidizing properties of oxygen, inhibition of a lipidic peroksidation, protection of a vascular endothelium against oxidizing action of hydroxylic radicals.

The cytoprotective effect is shown in inhibition of activation and adhesion of neutrophils, decrease in aggregation of erythrocytes and increase in resistance of erythrocytes to deformation, decrease in release of mediators of an inflammation.

Drug raises a venous and arterial reflux, extends time of venous filling, reduces inflow of blood to integuments (in a prone position), improves microcirculation and microvascular perfusion.

Effect of drug is directed to reduction of pain, improvement of various pathological disturbances connected with venous insufficiency.

Indications to use:

For a symptomatic treatment: venous insufficiency, prevaricose and varicose syndrome, superficial thrombophlebitis, phlebitis and posleflebitny states; for complex treatment of a hemorrhoidal disease; hypostases and pain at injuries and a varicosity; muscular kramp (convulsive tightening of gastrocnemius muscles).

Route of administration and doses:

Outwardly: gel is applied in the morning and in the evening on skin of an affected area, slightly rubbing the easy movements before full absorption of drug. At serious conditions the combination therapy with capsules of a trokserutin is recommended. At chronic venous insufficiency apply a combination therapy before total disappearance of symptoms. The dosage and duration of treatment defines the doctor individually, in view of weight and the course of a disease.

Features of use:

Use during pregnancy or feeding by a breast.

There are no data on a negative impact of drug at use during pregnancy or feeding by a breast.

Ability to influence the speed of reactions at control of motor transport or work with other mechanisms.

Does not influence.

Children.

There are no contraindications for drug use to children.

Side effects:

At gel use Trokserutin-Darnitsa such side reactions very seldom can be observed:

From skin and hypodermic cellulose: erythema, itch, skin rash, dermatitis.

Usually these symptoms quickly pass after drug phase-out.

Interaction with other medicines:

Strengthens kapillyaroprotektorny effect of ascorbic acid.

Contraindications:

Hypersensitivity to drug components.

Appropriate security measures at use.

It is not necessary to apply gel on open wounds, eczematic sites of skin, eye and mucous membranes.

Patients with the expressed renal failures are not recommended to use drug it is long.

If at drug use expressiveness of symptoms of a disease does not decrease, it is necessary to see a doctor.

Overdose:

At topical administration cases of overdose are not registered. At accidental swallowing a large amount of medicine it is necessary to take general measures on drug removal: to provoke vomiting, to apply means to a symptomatic treatment. In the presence of indications apply peritoneal dialysis.

Storage conditions:

Period of validity. 2 years. To store in the place, unavailable to children, in original packaging at a temperature not above 25 °C. Not to freeze.

Issue conditions:

Without recipe

Packaging:

On 30 g or on 50 g in a tuba, on 1 tuba in a pack.