Ribonuclease

General characteristics. Structure:

Active ingredient: 10 mg of ribonuclease.

The active fermental drug Ribonuclease is means of etiotropic treatment of viral infections that is defined by its ability to inactivate the RNA-containing viruses, splitting virus RNA — the carrier of infectious properties.

Pharmacological properties:

The fermental drug received from a pancreas of cattle. Depolymerizes RNA to acidsoluble mono - and oligopeptid. Liquefies pus, slime, a viscous and dense phlegm; has antiinflammatory effect. Destroying nucleic acids, reproduction of a number of the RNA-containing viruses detains.

Indications to use:

• a tick-borne encephalitis (at a severe disease);
• viral meningitis;
• periodontosis, ulitis;
• osteomyelitis, fistulas, abscesses, trophic ulcers;
• sinusitis (acute and aggravation of chronic), otitis (acute and aggravation of chronic);
• respiratory diseases with the hardly separated phlegm (a bronchoectatic disease, abscesses of lungs);
• thrombophlebitis.

Route of administration and doses:

For inhalations use a finely divided aerosol - 25 mg on 1 procedure (for this purpose drug dissolve in 3-4 ml 0,9% of solution of sodium of chloride or in 0,5% Procainum solution).

Vnutriplevralno – 25-50 mg in 5-10 ml of 0,9% of solution of sodium of chloride or 0,2% of solution of Procainum.

Endobronkhialno enter the solution containing 25-50 mg by means of the guttural syringe or a catheter (including at a bronkhoskopiya).

At periodontosis and an ulitis – 1% drug solution in 0,5% Procainum solution in the form of applications around the neck of tooth and cotton plugs in gingival pockets impregnated with the same solution. Procedure duration – 30 minutes, daily, within 10 days.

At topical administration powder a wound or ulcer surface with powder in number of 0,025-0,05 g and put the napkins or tampons moistened with drug solution in 0,9% chloride sodium solution within from 2 to 10 days.

At sinusitis - 5-10 mg in 3-5 ml of 0,9% of solution of sodium of chloride enter into a maxillary (Highmore's) bosom after a puncture and washing; at otitises enter into an ear on 0,5-1,0 ml 0,1% of the solution prepared for 0,9% chloride sodium solution. After introduction a bosom and a drum cavity to wash out in 30 min. 0,9% chloride sodium solution. The maximum single dose at local and intracavitary introduction – 50 mg.

Intramusculary (in oil) enter 5-10 mg into 1 ml of 0,9% of solution of sodium of chloride or 0,5% of solution of Procainum; a course of treatment of 2-10 injections on 1-2 injections a day.

For treatment of a tick-borne encephalitis – in oil, 6 times a day, each 4 hours in a single dose of 25-30 mg; children are 1-3 years old - 5-8 mg (depending on body weight), 4-6 years - 10-14 mg, 7-11 years - 15-18 mg, 12-15 years - 20 mg. The necessary amount of drug is dissolved before an injection in 2 ml of 0,25 or 0,5% of solution of Procainum. Before an initiation of treatment carry out a sensitivity test to drug: on the flexion surface of a forearm enter boiled and smoked 0,1 ml; in the absence of local and general reaction in an hour enter a full medical dose in oil. Use of drug is stopped in 2 days after normalization of temperature.

Features of use:

Any negative influence on ability to manage vehicles and mechanisms is noted.

There are no data on use of drug at pregnancy and during feeding by a breast.

Side effects:

Allergic reactions, hyperthermia, tachycardia. At intramuscular introduction – morbidity, a hyperemia on site injections, at inhalation introduction - irritation of mucous membranes of upper respiratory tracts, hoarseness.

Interaction with other medicines:

There are no data.

Contraindications:

Hypersensitivity to drug.

Chronic heart failure of the II-III stage, respiratory insufficiency, liver failure, pulmonary tuberculosis (open form), hemorrhagic diathesis.

With care: an empyema of a pleura of a tubercular etiology (the rassasyvaniye of exudate can promote development of a bronchopleural fistula).

Storage conditions:

In the place protected from light at a temperature not above 25 °C. To store in the place, unavailable to children.

Issue conditions:

According to the recipe

Packaging:

Lyophilisate for preparation of solution for intramuscular introduction and topical administration, a bottle of 5 ml contains 10 mg of Ribonuclease of active agent of the peptide nature. 10 bottles together with the application instruction in packaging.