LIDAZA - BIOFARM

General characteristics. Structure:

Active ingredient: 1 ampoule contains 64 PIECES of hyaluronidase.

Main physical and chemical properties: the powder condensed in a tablet or the lyophilized porous weight from cream till light brown color. On a surface the nayavnost of a dry crust is allowed.

Pharmacological properties:

Pharmacodynamics. Hyaluronidase is an enzyme as which specific substrate serves hyaluronic acid. The last is mucopolysaccharide which part are ацетилглюкозамин and glucuronic acid. Hyaluronic acid has high viscosity; biological value – the "cementing" intermediate substance of connecting fabric. The effect of drug consists in improvement of mobility of joints, a softening of hems, elimination or reduction of contractures, a rassasyvaniya of hematomas. Action is most expressed in an initial  stage of pathological processes.

Hyaluronidase ("spreading factor") causes disintegration of hyaluronic acid to a glycosamine and glucuronic acid and by that leads to increase in permeability of fabrics and improvement of the movement of interintercellular lymphs. The effect of hyaluronidase reversible – reduction of concentration recovers viscosity of hyaluronic acid.

Pharmacokinetics. It was not studied.

Indications to use:

Contractures of joints, ankylosing spondylarthritis, palmar fibromatosis (initial stage), cicatricial changes of skin of various origin, hematoma, scleroderma. Apply in eye practice (a keratitis, retinopathies), at a pulmonary tuberculosis, at traumatic defeats of neuroplexes and peripheral nerves, at a pseudorheumatism.

Route of administration and doses:

To Lidaz enter subcutaneously, under рубцово the changed fabrics, intramusculary, by methods of an electrophoresis or applications on mucous membranes (in eye practice). The drug can be administered also subkonjyunktivalno, retrobulbarno.

 For injections contents of an ampoule are dissolved in 1 ml of isotonic solution of sodium of chloride or in 1 ml of 0,5% of solution of novocaine.

At contractures, hems of various origin, hematomas, an ankylosing spondylarthritis enter under skin near the place of defeat or under рубцово changed тканьвзрослымв the volume of 1 ml. Injections daily or every other day. On a course of treatment of 6-10-15 injections.

At traumatic plexites and the same defeats of peripheral nerves enter subcutaneously every other day the adult in a dose 64 PIECES in novocaine solution. The course of treatment (12–15 injections) is repeated if necessary. At a pseudorheumatism drug is used by an electrophoresis method: adult 64 PIECES of a lidaza dissolve in 30 ml of the water distilled, add 4-5 drops 0,1nrastvora Acidum hydrochloricum and enter from the doubled electrode (anode) on two joints. Procedure duration – 20–30 minutes, a course of treatment – 10–15 sessions.

At productive character of an inflammation at suffering from tuberculosis easy the lidaza is appointed in the form of injections and inhalations in complex therapy for the purpose of increase in the center of defeat of concentration of antibiotics and other antibacterial agents. For inhalations contents of an ampoule are dissolved in 5 ml of isotonic solution of sodium of chloride. Inhalations of daily 1 times a day (5 ml of the solution containing 64 PIECES). On a course of 20-25 inhalations. Repeated courses – as necessary bucketed in 1,5-2 months.

For thinner scarring of affected areas of a cornea at a keratitis dig in drug solution (to dissolve 1 ampoule of drug in 20 ml of isotonic solution of sodium of chloride or in 20 ml of 0,5% of solution of novocaine) at simultaneous use of antibiotics, streptocides.

At retinopathies enter also under temple skin 0,5 mlrastvor (to dissolve 1 ampoule of drug in 20 ml of isotonic solution of sodium of chloride or in 20 ml of 0,5% of solution of novocaine). The course of treatment makes 10-15 procedures.

Features of use:

At fresh hemorrhages drug is not used.

Side effects:

Lidaza is well had, but there can sometimes be allergic reactions with skin manifestations.

Interaction with other medicines:

Lidaza of uskoryaetvsasyvaniyedrugy medicines (local anesthetics, isotonic solutions, muscle relaxants, etc.) at hypodermic and intramuscular introduction of the last.

Contraindications:

Malignant new growths.

Overdose:

In case of drug overdose, at emergence of skin and allergic reactions to cancel drug.

Storage conditions:

Store in dry, protected from light and the place, unavailable to children, at a temperature not above 15 °C. A period of validity – 2 years.

Issue conditions:

According to the recipe

Packaging:

On 10 ampoules in cardboard packaging.