Lidaza

General characteristics. Structure:

Active ingredient: 64 ME hyaluronidases.

Excipient: 0,9% solution of sodium of chloride.

Specially purified fermental medicine with proteolytic activity containing hyaluronidase in quality of active agent.

Pharmacological properties:

Pharmacodynamics. The fermental drug emitted from seed plants of cattle. Splits the main component of interstitial substance of connecting fabric - hyaluronic acid (mucopolysaccharide which part are ацетилглюкозамин and glucuronic acid, is a cement substance of connecting fabric), reduces its viscosity, increases fabric and vascular permeability, facilitates the movement of liquids in interfabric spaces; reduces puffiness of fabric, softens and flattens hems, increases the volume of movements in joints, reduces contractures and prevents their formation. Hyaluronidase causes disintegration of hyaluronic acid to a glycosamine and glyukurovy acid and by that reduces its viscosity. Action duration at boiled and smoked introduction - to 48 h.

Indications to use:

Burn, traumatic, postoperative hems; it is long not healing ulcers (including beam); palmar fibromatosis; rigidity of joints, contractures of joints (after inflammatory processes, injuries), the osteoarthrosis ankylosing a spondylarthritis, a serious illness of lumbar disks; chronic tendovaginitis, scleroderma (skin manifestations), hematoma of soft tissues of superficial localization; preparation for skin plastic surgeries concerning cicatricial styazheniye.

Myocardial infarction, hydrocephaly.

The pulmonary tuberculosis (complicated by nonspecific damages of bronchial tubes), inflammatory processes in upper respiratory tracts and bronchial tubes with the obstruction phenomena.

Complex therapy of allergic rhinitis, pseudorheumatism, arachnoiditis.

Traumatic defeats of neuroplexes and peripheral nerves (plexitis, neuritis).

For improvement of absorption of the medicines entered п / to and in oil.

Hyphema, hemophthalmia, retinopathy of various etiology.

Route of administration and doses:

At cicatricial defeats п / to (under the cicatricial changed fabrics) or in oil (near the place of defeat) enter on 64 UE (1 ml) daily or every other day (only 10-20 injections).

At traumatic defeats of neuroplexes and peripheral nerves enter п / to into the area of the affected nerve (64 UE in Procainum solution) every other day; on a course - 12-15 injections. The course of treatment is repeated if necessary.

In ophthalmology: subkonjyunktivalno - 0.3 ml, parabulbarno - 0.5 ml, and also an electrophoresis method.

The TB patient of lungs with productive character of an inflammation appoint in complex therapy for increase in concentration of antibacterial medicines in the centers of defeat in a type of injections and/or inhalations. Inhalations carry out daily 1 time, using 5 ml of solution (320 UE). The course of treatment consists of 20-25 inhalations. If necessary conduct repeated courses with intervals of 1.5-2 months.

Outwardly, in the form of the bandages impregnated with drug solution. For solution preparation everyone 64 UE dissolve sterile 0.9% of solution of sodium of chloride or boiled water of room temperature in 10 ml. Moisten with this solution the sterile bandage put in 4-5 layers, impose it on an affected area, cover with wax paper and fix a soft bandage. The dose depends on the area of defeat (20-60 ME/kv.sm), on average - 300 ME on a bandage. The bandage is applied daily 15-18 h within 15-60 days. At prolonged use in each 2 weeks do a break for 3-4 days.

At use by method of an electrophoresis 300 ME dissolve in 60 ml of the distilled water, add 2-3 cap of 0.1% of solution of chlorohydrogen acid and enter from the anode on an affected area within 20-30 min. A course of treatment - 15-20 sessions. The application mode of dosing can be alternated to an electrophoresis. The prepared solution has to be used during 24 h

Features of use:

Solution should not be entered through a catheter into which entered the solutions containing cations earlier.

Solutions for injections prepare for 0.9% solution of sodium of chloride or 0.5% Procainum solution, for inhalations - for 0.9% chloride sodium solution, for an electrophoresis - on the distilled water.

Before an initiation of treatment it is reasonable to carry out the test with boiled and smoked introduction 20 мкл hyaluronidases.

It is not necessary to enter into zones of an infectious inflammation and a tumor.

With care appoint at pregnancy and in the period of a lactation.

Side effects:

Allergic reactions; at prolonged use - local irritative action.

Interaction with other medicines:

Improves absorption of the medicines entered subcutaneously or intramusculary, strengthens effect of local anesthetics.

Contraindications:

Overdose:

Symptoms: fever, nausea, vomiting, dizziness, tachycardia, decrease in the ABP, local hypostasis, small tortoiseshell, erythematic rashes.

Treatment: introduction of Epinephrinum, GKS; antihistaminic drugs

Storage conditions:

In the dry, protected from light place at a temperature not above +15 degrees Celsius. To protect from children.

Issue conditions:

According to the recipe

Packaging:

1 bottle with the lyophilized powder contains Lidaza 64 UE, in packaging of 10 pieces.