Алмагель® NEO

General characteristics. Structure:

Active agents: 5 ml (one measured spoon) of suspension contain:
Algeldrat (Aluminum hydroxide gel - in terms of aluminum hydroxide) 340 mg
Magnesium hydroxide (Magnesium hydroxide paste - in terms of magnesium hydroxide) 395 mg
Simetikon (an emulsion of a simetikon - in terms of диметикон) 36 mg

Excipients: peroxide hydrogen solution of 30%, sorbitol, sodium saccharinate, a gietelloz, citric acid monohydrate, ethylparahydroxybenzoate, пропилпарагидроксибензоат, propylene glycol, a macrogoal 4000, fragrance orange, ethanol of 96%, the water purified.

Description

White or almost white suspension, with an orange smell.

Pharmacological properties:

Pharmacodynamics. The combined means which action is caused by the components which are its part. Renders the antiacid, adsorbing, enveloping, carminative action. Algeldrat (aluminum hydroxide) and magnesium hydroxide neutralize free hydrochloric acid in a stomach, lower acidity of a gastric juice, connect bile acids. Aperient effect of magnesium of hydroxide counterbalances ability of an algeldrat to slow down motility of intestines. Simetikon complicates formation of gas bubbles and promotes their destruction. The gases released at the same time are absorbed by walls of intestines and removed from an organism thanks to a peristaltics.

Pharmacokinetics. Simetikon owing to physiological and chemical inertness is not soaked up in bodies and fabrics and after passing through the digestive tract (DT) is brought in an invariable look. Absorption of ions of aluminum and magnesium in intestines - low. At normal function of kidneys concentration of aluminum and magnesium in blood does not change. Patients with a chronic renal failure have a level of aluminum and magnesium in blood can increase to toxic values as a result of disturbance of their removal.

Indications to use:

Acute gastritis; chronic gastritis with the increased and normal secretory function of a stomach (in an aggravation phase); acute duodenitis, duodenogastralny reflux; a peptic ulcer of a stomach and duodenum (in an aggravation phase); symptomatic ulcers of a GIT of various genesis; erosion of a mucous membrane of upper parts of digestive tract; gastroesophageal reflux, reflux esophagitis; acute pancreatitis, exacerbation of chronic pancreatitis; a gastralgia, heartburn (after the excess use of ethanol, nicotine, coffee, reception of medicines; the incorrect diet which is negatively affecting functioning of a GIT); meteorism; fermentative or putrefactive dyspepsia.

Route of administration and doses:

Adults

Inside, on 2 measured spoons of suspension with an orange flavor 4 times a day in 1 hour after meal and in the evening before going to bed. If necessary it is possible to increase a single dose to 4 measured spoons, but the maximum daily dose should not exceed 12 measured spoons.

Children are more senior than 10 years

Dosage the attending physician - usually defines 1/2 doses for adults.

Course of treatment - no more than 4 weeks. Before reception suspension needs to be homogenized, stirring up a bottle. It is desirable to accept Almagel® Neo in not divorced look. Reception of liquid within half an hour after administration of drug is not recommended.

Features of use:

The interval between reception of Almagelya® of Neo and other medicines has to make 1-2 hours.

At long reception it is necessary to provide sufficient intake of phosphorus with food.

Due to the lack of these controlled clinical tests the nursing women of Almagel® Neo should accept only after consultation with the doctor. One measured spoon (5 ml) of drug contains 0,113 g of alcohol therefore emergence of complications at patients with diseases of a liver and brain is possible, at having alcoholism and epilepsy, at pregnant women and children up to 18 years. The daily dose of drug (8 measured spoons) contains 0,904 g of alcohol, the maximum daily dose of suspension (12 measured spoons) contains 1,356 g of alcohol.

One measured spoon (5 ml) of the drug Almagel® Neo contains 0,475 g of sorbitol which is contraindicated at inborn intolerance of fructose and can cause irritation of a stomach and diarrhea.

Does not make negative impact on ability of control of motor transport and work with the mechanisms demanding the increased concentration of attention and speed of psychomotor reactions.

Side effects:

Allergchesky reactions, nausea, vomiting, change of flavoring feelings, lock, diarrhea. At long reception in high doses - a hypophosphatemia, a hypocalcemia, a hypercalcuria, osteomalacy, osteoporosis, a gipermagniyemiya, a giperalyuminiyemiya, encephalopathy, a nephrocalcinosis, a renal failure. Patients with the accompanying renal failure have a thirst, a lowering of arterial pressure, a hyporeflexia.

Interaction with other medicines:

Almagel Neo reduces and slows down absorption of digoxin, indometacin, salicylates, Chlorpromazinum, Phenytoinum, locators of Ng-gistaminovykh of receptors, beta adrenoblockers, a diflunisal, a ketokonazol and an itrakonazol, an isoniazid, antibiotics of a tetracycline row and hinolon, azithromycin, a tsefpodoksim, a pivampitsillin, rifampicin, indirect anticoagulants, barbiturates, a feksofenadin, Dipiridamolum, a zaltsitabin, chenodesoxycholic and ursodezoksikholevy acids, Penicillaminum and lansoprazol.

M-holinoblokatory, slowing down gastric emptying, strengthen and extend effect of drug.

Contraindications:

Hypersensitivity, chronic renal failure, pregnancy, Alzheimer's disease, hypophosphatemia, children's age up to 10 years, inborn intolerance of fructose.

With care - the period of a lactation, a liver disease, alcoholism, a craniocereberal injury, brain diseases, epilepsy, children's and teenage age from 10 to 18 years.

Overdose:

Symptoms. Long use of high doses can lead to development of a gipermagniyemiya that is characterized by bystry fatigue, face reddening, exhaustion, muscular weakness and inadequacy of behavior. Also signs of a metabolic alkalosis can be observed: change of mood, cerebration disturbance, numbness or muscle pain, nervousness and bystry fatigue, breath delay, unpleasant flavoring feelings. Urgent measures. It is necessary to take measures for bystry removal of drug at once - a gastric lavage, stimulation of vomiting, reception of absorbent carbon.

Storage conditions:

In the place protected from light at a temperature not above 25 °C. Not to freeze! To store in the place, unavailable to children! Period of validity 2 years. Not to apply after the period of validity specified on packaging.

Issue conditions:

Without recipe

Packaging:

Suspension for intake.

On 170 ml or on 200 ml of drug in a glass bottle. Each bottle together with the application instruction and a measured spoon on 5 ml in a cardboard pack.

On 170 ml or on 200 ml of drug in a bottle from polyethyleneterephthalate. Each bottle together with the application instruction and a measured spoon on 5 ml in a cardboard pack.