Dioksizol-Darnitsa

General characteristics. Structure:

Active ingredient: 1 ml of solution contains a dioxidin – 12 mg; hydrochloride lidocaine (in terms of anhydrous substance) – 60 mg;

excipients: propylene glycol, проксанол 268, the water purified.

Pharmacological properties:

Диоксизоль®-Дарница – the combined medicine for topical administration which active ingredients are the dioxidin and lidocaine.

The dioxidin – possesses the expressed antibacterial action concerning gram-negative and gram-positive, aerobic and anaerobic, spore-forming and asporogenic microflora (a pyocyanic stick, stafilokokk, streptococci, clostridiums, bacteroids, peptokokk, etc.) in the form of monocultures and microbic associations, including hospital strains of bacteria with polyresistance to other antibacterial drugs.

Lidocaine – mestnoanesteziruyushchy action is caused by blockade of potentsialzavisimy Na+-channels that interferes with generation of impulses in the terminations of sensory nerves and to carrying out impulses on nerve fibrils. At topical administration expands vessels, has no local irritative effect.

The effect develops in 1–5 min. after drawing on skin.

Its ability to damage DNA of bacteria is the cornerstone of antibacterial effect of drug. As a result of such influence synthesis of bacterial nucleases is slowed down, the ultrastructure of a bacterial cell is broken, there is a thickening of a cellular cover and disturbance of structure of membranes. Cytostatic effect of drug is mediated by impact on sites of a genome responsible for synthesis of exoenzymes,

causing virulence what ability of Dioksizolya®-Darnitsa to interfere with development of resistance in microorganisms is connected with. Диоксизоль®-Дарница possesses strong mestnoanesteziruyushchy and moderate giperosmolyarny action, stops a wound and perifocal inflammation, stimulates processes of a reparation and activity of phagocytes in a wound.

Indications to use:

Contaminated wounds of soft tissues of various localization and genesis (amputating stumps of extremities, wounds after surgical treatment of suppurative focuses, decubituses, trophic ulcers, purulent postoperative wounds and fistulas, a paraproctitis, abscesses and phlegmons of maxillofacial area, etc.), burns of the II-IV degrees, chronic and acute osteomyelitis, preparation of wounds for an autodermoplastika, prevention of pyoinflammatory processes in surgery and Combustiology when performing various plastic surgeries.

Route of administration and doses:

Диоксизоль®-Дарница appoint locally. In the absence of an allergy drug is used directly after surgical treatment of wounds and burns, and also in further process of their treatment, previously clearing a wound surface of exudate and necrotic fabrics. The sterile dressing material (gauze bandages or tampons) is plentifully saturated with solution and applied on superficial burns or entered into deep wounds then impose sterile napkins which fix bandage or an adhesive plaster. Bandages change 1 time in 7–14 days at treatment of burns and 1 times a day – at treatment of wounds. Into fistulas, wound cavities and pockets solution is entered a catheter by means of the syringe, by 1–2 times a day, with further imposing of a sterile gauze bandage. The amount of drug necessary for single application depends on the sizes of wounds. The daily dose of Dioksizolya®-Darnitsa at topical administration should not exceed 100 g, and at introduction to cavities – 50–60 g. Duration of treatment is defined by terms of elimination is purulent - serous exudation and an infection in a wound, and also dynamics of healing of wounds. The course of treatment should not exceed 15 days.

Features of use:

The relevant activities of safety at use. Before use of drug it is necessary to carry out a skin allergy test on portability of drug (on the internal surface of a forearm, subcutaneously). In case of positive reaction of Dioksizol®-Darnitsa do not apply.

Диоксизоль®-Дарница apply only the adult.

With care to appoint the patient with dysfunction of epinephral glands, a liver, patients with a renal failure.

Drug is used preferential in the first phase of a wound process, and also in the second phase at the granulating wounds with zones of necroses and inflammations.

Use during pregnancy or feeding by a breast. Drug is contraindicated during pregnancy. During treatment it is necessary to stop feeding by a breast

Ability to influence the speed of reactions at control of motor transport or other mechanisms. During treatment it is necessary to abstain from driving of motor transport and from occupations potentially dangerous types of activity requiring special attention and speed of mental and motor reactions.

Children. Drug is not appointed to children.

Side effects:

From cardiovascular system: arterial hypotension, bradycardia.

From a nervous system: nervousness and/or depression.

Others: Urticaria, around wound dermatitis.

When drawing on burn wounds perhaps short-term burning sensation which disappears independently in a few minutes and does not need drug withdrawal.

Interaction with other medicines:

Interaction of Dioksizol®-Darnitsa solution with other drugs is not revealed, however it is not recommended to be applied along with other ointments or creams.

Contraindications:

Hypersensitivity to drug components. Cardiogenic shock, AV blockade of the II-III degree, bradycardia. Pregnancy and feeding by a breast, children's age.

Overdose:

Symptoms: nervousness and/or depression, arterial hypotension, bradycardia, sometimes spasms.

Treatment: Oxygenotherapy. At hypotension it is possible to appoint sympathomimetics together with agonists of β-receptors.......... At bradycardia it is possible to apply atropine of 0,5-1 mg intravenously. Spasms it is necessary to treat by means of 50–100 mg of a suktsinilkholin and/or 5–15 mg of diazepam.

Storage conditions:

To store in the place, unavailable to children, in original packaging, at a temperature from 15 °C to 25 °C. A period of validity - 2 years.

Issue conditions:

Without recipe

Packaging:

On 50 g, 100 g, 500 g, 1000 in bottles or banks polymeric.