Papaverin-Zdorovye, solution for infection 2% on 2 ml No. 10

General characteristics. Structure:

International and chemical names: papaverine; 1 (3,4-dimetoksi-Benzylium) - a 6,7-dimetoksiizokhinolina a hydrochloride;
main physical and chemical properties: liquid, transparent with slightly yellowish shade;
structure: 1 ml of drug contains a papaverine of a hydrochloride 20 mg;
excipients: dinatrium эдетат, methionine, water for injections.

Pharmacological properties:

Pharmacodynamics. Myotropic, spasmolytic and antihypertensive.
Blocks phosphodiesterase, causes accumulation of tsAMF and decrease in content of calcium in a cell. Reduces a tone and weakens unstriated muscles of internals (digestive tract, respiratory and urinogenital system) and vessels. Causes an arteriectasia, promotes increase in a blood-groove, including cerebral.
In high doses reduces excitability of a cardiac muscle and slows down endocardiac conductivity.
Action on the central nervous system is expressed poorly (in high doses renders sedative эффåprom-rus.com/admin/preparat_edit.phpкт).

Pharmacokinetics. Extent of absorption high; bioavailability on average – 54%. Linkng with proteins of plasma – 90%, forms steady complexes with blood serum albumine. It is well distributed in body tissues, gets through gistogematichesky barriers. It is metabolized in a liver. An elimination half-life – 0,5–2 h (it can be extended to 24 h). It is removed generally by kidneys in the form of metabolites.
Completely is removed from blood at a hemodialysis.

Indications to use:

Spasm of unstriated muscles of abdominal organs (cholecystitis, pylorospasm, spastic colitis, renal colic), peripheral vessels (endarteritis), vessels of a brain, heart (stenocardia as a part of complex therapy).

Route of administration and doses:

Appoint subcutaneously, intramusculary and intravenously. The dose and the mode of dosing are selected individually. The most effective is intravenous administration which is carried out slowly, previously having parted 1 ml of drug in 10–20 ml of isotonic solution of sodium of chloride.
Subcutaneously or intramusculary the adult 2–4 times a day enter in a single dose 10–40 mg (0,5–2 ml); for elderly patients an initial single dose – no more than 10 mg (0,5 ml). Intravenously enter in a single dose 20 mg (1 ml) with an interval between introductions not less
4 h.
The maximum doses for adults at hypodermic or intramuscular introduction: one-time – 100 mg (5 ml), daily – 300 mg (15 ml); at intravenous administration: one-time – 20 mg (1 ml), daily – 120 mg (6 ml).
To children enter intramusculary or intravenously in the dose of 6 mg/kg/day divided into 4 injections. The maximum daily dose for children makes: at the age of 1–2 years – 20 mg
(1 ml), 3–4 years – 30 mg (1,5 ml), 5–6 years – 40 mg (2 ml), 7–9 years – 60 mg (3 ml), 10–14 years –
100 mg (5 ml).

Features of use:

Intravenous administration should be carried out slowly and under control of the doctor.
Restriction to use is advanced age (risk of development of a hyperthermia).
Safety of use of a papaverine at pregnancy and during feeding by a breast is not investigated therefore it is necessary to use drug taking into account a risk/advantage ratio.
Drug is appointed with care and in small doses at a serious illness of heart, states after craniocereberal injuries, a chronic renal failure, insufficiency of function of adrenal glands, a hypothyroidism, to the hyperplasia of a prostate, supraventricular tachycardia, depressed cases weakened by the patient.
Against the background of therapy by drug it is necessary to exclude alcohol intake.
Efficiency of drug decreases at tobacco smoking.
Influence on ability to manage vehicles and mechanisms. When performing potentially dangerous types of activity it is necessary to consider possibility of side reactions from cardiovascular system, drowsiness, a diplopia.

Side effects:

Drowsiness, headache, nausea, diplopia, lock, perspiration, allergic reactions. At use of drug in high doses or at its excessively bystry intravenous administration arrhythmia, a total or partial atrioventricular block, ventricular premature ventricular contraction, fibrillation of ventricles, arterial hypotension, a dermahemia of an upper part of a trunk are possible.

Interaction with other medicines:

Spasmolytic action of a papaverine is strengthened by barbiturates. The hypotensive effect amplifies at combined use with anti-hypertensive drugs of other groups, and also with tricyclic antidepressants, procaineamide, Reserpinum, quinidine. Strengthens anticholinergic effects of anticholinergic drugs. The papaverine can reduce protivoparkinsonichesky effect of a levodopa and hypotensive effect Methyldopums. At simultaneous use with alprostadily for intrakavernozny introduction there is a risk of development of a priapism.

Contraindications:

Hypersensitivity to components of drug, disturbance of atrioventricular conductivity, arterial hypotension, glaucoma, a heavy liver failure, children's age till 1 year.

Overdose:

Symptoms: drowsiness, hypotension, vision disorder.
Treatment: it is necessary to stop use of drug and to carry out a symptomatic treatment.

Storage conditions:

To store in the place protected from light at a temperature from 15 °C to 25 °C. To store in the place, unavailable to children.
Period of validity – 2 years.

Issue conditions:

According to the recipe

Packaging:

Ampoules on 2 ml No. 5х2 in a blister strip packaging and in a pack; No. 10 in a pack.