Полижинакс

General characteristics. Structure:

Main physical and chemical properties: the oval capsule of light yellow color which contains oily homogeneous semi-fluid mass. Contents of the capsule of yellow or brown color, inodorous;

Structure: 1 vaginal capsule contains Neomycinum sulfate of 35 000 ME, polymyxin In sulfate of 35 000 ME, nystatin of 100 000 ME; Excipients: dimethyl polysiloxane, a tefoza 63, the oil soy hydrogenated gelatin, glycerin, the water purified.

Pharmacological properties:

Pharmacokinetics. Comprise the properties inherent in separate components of drug: Neomycinum sulfate an aminoglikozidny antibiotic, possesses bactericidal action concerning a wide range of gram-positive and gram-negative microorganisms: Corynebacterium spp., Staphylococcus spp., Mycobacterium tuberculosis, Enterococcus faecium, Escherichia coli, Enterobacter aerogenes, Haemophilus influenzae, Klebsiella pneumoniae, Ptoteus vulgaris etc., by blocking of function of bacterial ribosomes; polymyxin sulfate In the antibiotic of the polypeptide nature operating bakteritsidno preferential gram-negative flora, especially Pseudomonas aeruginosa; also strains E are sensitive. coli, Schigellae, Klebsiellae, Pasteurellae, Serratiae, Staphylococcus spp., Enterobacter, Salmonellae, Haemophilus, Bordetella. Polymyxin B breaks osmotic resistance of membranes of bacteria, is also active concerning activators which are in a rest stage. Nystatin the half-yen antibiotic operating fungitsidno and fungistatichno by binding of ergosterol of a cytoplasmic membrane of mushrooms. Shows activity concerning Candida spp., Histoplasma spp., Coccidioides spp., Cryptococcus spp., Aspergillus, Blastomyces dermatidis. Dimethyl polysiloxane organic compound with a high molecular weight, has the enveloping properties and antipruritic action, improves trophic processes in a mucous membrane of a vagina, and also promotes penetration of active components of drug into folds of a mucous membrane.

Pharmacokinetics. Three active components of drug are applied in usual concentration, it is much less (from 10 to 100 times), than at oral administration of these components. The possibility of absorption of components of drug is very small. Neomycinum. Absorption of Neomycinum is insignificant. Polymyxin B. It is an antibiotic which is not absorbed at topical administration. Nystatin. Practically it is not absorbed by mucous membranes at local use.

Indications to use:

Treatment of a vaginitis, vulvovaginitis, cervicitis (bacterial, fungal or mixed), caused by sensitive flora, prevention of infectious complications at gynecologic operative measures, childbirth, abortion, installation of an intrauterine spiral, diathermocoagulation of a neck of uterus, a gisterografiya, intra urethral researches.

Route of administration and doses:

One capsule a day. A course of treatment of 12 days, a preventive course - 6 days. The capsule is used intravaginalno in the evening before going to bed. Not to stop treatment during periods. In children's practice the special form - Polizhinaks Virgo is applied.

Features of use:

Before purpose of drug carrying out a bacteriological research of allocations from a vagina is necessary. At use of drug not to use contraceptive caps and condoms from latex and a spermitsida. To avoid transfer of a disease, the patient needs to warn about use by separate personal hygiene means (a bast, a towel, etc.), wearing linen from organic cotton, during treatment to use hygienic tampons.

Precautionary measures: in the absence of data on fraction of Neomycinum and the polymyxin B absorbed by mucous it is impossible to exclude completely a possibility of system effects, especially at prolonged use of drug. Pregnancy and lactation: during pregnancy and a lactation it is not recommended to use drug without appointment of the doctor.

Side effects:

At use of drug in the recommended doses the risk of emergence of undesirable effects is minimum. Side effects of aminoglycosides are found very seldom at their local use. At local use of drug allergic reactions arise quite seldom; reactions of local irritation also happen in isolated cases. Has no teratogenic effect. Owing to practical lack of absorption of components of drug mucous even in case of its filling there are also no system effects.

Interaction with other medicines:

Data on side effects of interaction of drug of Polizhinaks with other medicines are absent.

Contraindications:

Hypersensitivity to drug components.

Overdose:

Messages on overdose of drug of Polizhinaks were not.

Storage conditions:

To store at the room temperature (15-25 ˚С). To store in unavailable to children. A period of validity - 1,5 years.

Issue conditions:

According to the recipe

Packaging:

6 or 12 vaginal capsules in blisters in cardboard packaging with a leaf insert.