Trimistin-Darnitsa

General characteristics. Structure:

Acting veshchestvo:1 with of ointment contains in terms of 100% acetonide Triamcinolonum substance – 0,25 mg, a miramistina in terms of anhydrous substance – 5 mg

excipients: propylene glycol, a beta cyclodextrin, stearyl alcohol, cetyl alcohol, the water purified.

Pharmacological properties:

Trimistin®-Darnitsa ointment – the combined drug for topical administration.   Active ingredients of ointment are Triamcinolonum acetonide and мирамистин.

Triamcinolonum – the fluorinated glucocorticosteroid, renders the expressed antiinflammatory, antiallergic and anti-exudative action. Interacting with a specific proteinaceous receptor in target tissues, regulates an expression of kortikoidzavisimy genes and influences protein synthesis. Reduces education, release and activity of mediators of an inflammation (a histamine, a kinin, prostaglandins, lizosomalny enzymes). Suppresses migration of cells to the place of an inflammation; reduces a vazodilatation and permeability of vessels in the inflammation center. Stabilizes lizosomalny enzymes of membranes of leukocytes; suppresses synthesis of antibodies and breaks antigen recognition. Slows down release interleykina-1, interleykina-2, interferon scale from lymphocytes and macrophages. Induces formation of a lipokortin, release by eosinophils of mediators of an inflammation oppresses and stabilizes membranes of mast cells. All these effects participate in suppression of inflammatory reaction in fabrics in response to mechanical, chemical or immune destruction.

Miramistin – an antiseptic agent of a broad spectrum of activity, has bactericidal effect (hydrophobic interaction with membranes of microorganisms leads to their destruction). It is effective concerning gram-positive (preferential) and gram-negative microorganisms (including aerobes and anaerobe bacterias), spore-forming and asporous microflora in the form of monocultures and microbic associations (including hospital strains with polyresistance to antibiotics). Has antifungal effect on ascomycetes of the sort Aspergillus and the sort Penicillium, barmy mushrooms (Rhodotorula rubra, Torulopsis gabrata, etc.) and drozhzhepodobny (Candida albicans, Candida tropicalis, Candida krusei, etc.), dermatophytes (Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton verrucosum, Trichophyton schoenleinii, Trichophyton violaceum, Epidermophyton Kaufman-Wolf, Epidermophyton floccosum, Microsporum gypseum, Microsporum canis, etc.), and also on other pathogenic fungi, for example Pityrosporum orbiculare (Malassezia furfur), in the form of monocultures and microbic associations, including fungal microflora with resistance to chemotherapeutic medicines. Effectively prevents infection of wounds, activating regeneration processes.

Special physical and chemical characteristics of an ointment basis, and the high-molecular polymers which are also in a basis with sorption properties, hold active components of ointment on site of drawing and their diffusions in a system blood stream interfere.

Indications to use:

The inflammatory diseases of skin including complicated by a bacterial and fungal infection: eczema, atopic dermatitis, neurodermatitis, psoriasis in the progressing stage and in an exudative form, a parapsoriasis, a pemphigus, contact dermatitis, seborrheal dermatitis, dermatitis of Dyuringa, a diskoidny lupus erythematosus, a photodermatosis, a skin lymphoma.

Route of administration and doses:

Outwardly. Ointment is applied a thin layer on affected areas by 1-2 times a day, slightly rubbing in skin, within 5-10 days. Treatment is continued before elimination of inflammatory process, the termination of an itch and clarification of skin.

At exudation before drug use the erosive surface is processed acid solutions of boric 1%, peroxide of hydrogen of 3% or a hlorgeksidina of a biglyukonat of 0,05%. If necessary ointment is applied under a sterile gauze bandage.

Features of use:

Effect of ointment partially weakens at its drawing on a surface with high content is purulent - necrotic masses. Therefore it is better to apply ointment on skin after its processing by warm soap solution or, if necessary, solutions of antiseptic agents.

Use during pregnancy or feeding by a breast.

Controlled researches on pregnant women were not conducted, use is possible if the advantage for mother exceeds risk for a fruit.

Ability to influence the speed of reactions at control of motor transport or other mechanisms. During treatment it is necessary to be careful during the driving of motor transport and occupation other potentially dangerous types of activity demanding the increased concentration of attention and speed of psychomotor reactions.

Children. At use of ointment for children after 1 year is also more senior it is necessary to limit the general duration of treatment and to exclude the actions leading to strengthening of a resorption and absorption of steroids (warming, fixing and occlusive bandages).

Side effects:

At ointment use sometimes there is a feeling of easy burning.

Interaction with other medicines:

Efficiency of treatment by Trimistin®-Darnitsa ointment can increase at co-administration of system anti-histamine drugs, antibiotics and antimicrobic means.

Efficiency of treatment by Trimistin®-Darnitsa ointment decreases at co-administration of other ointments containing sorbents.

Contraindications:

Hypersensitivity to Triamcinolonum and a miramistin. The tuberculosis cutis which is localized in the place of application of ointment, syphilitic damages of skin, skin reactions after vaccination. Carcinoma cutaneum. Drug is not appointed to pregnant women and children of the first year of life.

Overdose:

It is improbable. When putting ointment on the extensive surfaces of the affected skin, the possibility of partial hit of active components of ointment in a system blood stream in the quantities not capable to cause acute poisoning is not excluded.

Storage conditions:

Period of validity. 2 years. In original packaging, at a temperature from 15 °C to 25 °C. Freezing of drug is not allowed.

Issue conditions:

Without recipe

Packaging:

Ointment on 10 g, 14 g and 20 g in tubas.